Synergistic Chromatin-Modifying Treatments Reactivate Latent HIV and Decrease Migration of Multiple Host-Cell Types

Screening for gene expression fluctuations reveals latency-promoting agents of HIV

(2021) Yiyang Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Latency and Viral Reservoirs: Existing Reversal Approaches and Potential Technologies, Targets, and Pathways Involved in HIV Latency Studies

(2021) Sushant Khanal et al.   Cells

Block-And-Lock Strategies to Cure HIV Infection

(2020) Gerlinde Vansant et al.   Viruses-Basel

Current Status of Latency Reversing Agents Facing the Heterogeneity of HIV-1 Cellular and Tissue Reservoirs

(2020) Amina Ait-Ammar et al.   Frontiers in Microbiology

Block-And-Lock: New Horizons for a Cure for HIV-1

(2020) Ines Moranguinho et al.   Viruses-Basel

Heterogeneous HIV-1 Reactivation Patterns of Disulfiram and Combined Disulfiram+Romidepsin Treatments

(2019) Anna Kula et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

The HIV Reservoir in Monocytes and Macrophages

(2019) Michelle E. Wong et al.   Frontiers in Immunology

Advances towards curing HIV-1 infection from tissue reservoirs

(2019) Lisa J. Henderson et al.   JOURNAL OF VIROLOGY

NF-κB-Chromatin Interactions Drive Diverse Phenotypes by Modulating Transcriptional Noise

(2018) Victor C. Wong et al.   Cell Reports

Barriers for HIV Cure: The Latent Reservoir

(2018) Sergio Castro-Gonzalez et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Cell Size-Based Decision-Making of a Viral Gene Circuit

(2018) Kathrin Bohn-Wippert et al.   Cell Reports

Defining total-body AIDS-virus burden with implications for curative strategies

(2017) Jacob D Estes et al.   NATURE MEDICINE

Synergistic reactivation of latent HIV-1 provirus by PKA activator dibutyryl-cAMP in combination with an HDAC inhibitor

(2017) Hoyong Lim et al.   VIRUS RESEARCH

Similarity in viral and host promoters couples viral reactivation with host cell migration

(2017) Kathrin Bohn-Wippert et al.   Nature Communications

In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment

(2017) Cari F. Kessing et al.   Cell Reports

Transcriptional Bursting Explains the Noise–Versus–Mean Relationship in mRNA and Protein Levels

(2016) Roy D. Dar et al.   PLoS One

Sequential treatment with 5-aza-2'-deoxycytidine and deacetylase inhibitors reactivates HIV-1

(2015) S. Bouchat et al.   EMBO Molecular Medicine

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

HIV-1 reprograms the migration of macrophages

(2014) C. Verollet et al.   BLOOD

Screening for noise in gene expression identifies drug synergies

(2014) R. D. Dar et al.   SCIENCE

Long-lived reservoirs of HIV-1

(2014) Thomas D. Zaikos et al.   TRENDS IN MICROBIOLOGY

HIV-1 Latency in Monocytes/Macrophages

(2014) Amit Kumar et al.   Viruses-Basel

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism

(2013) Daniela Boehm et al.   CELL CYCLE

Comparison of HDAC inhibitors in clinical development

(2013) Thomas Aagaard Rasmussen et al.   Human Vaccines & Immunotherapeutics

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

(2013) Celsa A. Spina et al.   PLoS Pathogens

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

(2012) Liang Shan et al.   IMMUNITY

BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

(2012) Camellia Banerjee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HIV-infected T cells are migratory vehicles for viral dissemination

(2012) Thomas T. Murooka et al.   NATURE

Shock and kill

(2012) Steven G. Deeks   NATURE

Transcriptional burst frequency and burst size are equally modulated across the human genome

(2012) R. D. Dar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactivation of Latent HIV-1 by Inhibition of BRD4

(2012) Jian Zhu et al.   Cell Reports

Global landscape of HIV–human protein complexes

(2011) Stefanie Jäger et al.   NATURE

Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency

(2011) Haleh Rafati et al.   PLOS BIOLOGY

Transcriptional Bursting from the HIV-1 Promoter Is a Significant Source of Stochastic Noise in HIV-1 Gene Expression

(2010) Abhyudai Singh et al.   BIOPHYSICAL JOURNAL

Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid

(2009) Nancie M. Archin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV-1 regulation of latency in the monocyte-macrophage lineage and in CD4+ T lymphocytes

(2009) Laetitia Redel et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transcriptional Restriction of Human Immunodeficiency Virus Type 1 Gene Expression in Undifferentiated Primary Monocytes

(2009) C. Dong et al.   JOURNAL OF VIROLOGY

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

(2009) Sophie Reuse et al.   PLoS One

HIV interactions with monocytes and dendritic cells: viral latency and reservoirs

(2009) Christopher M Coleman et al.   Retrovirology

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

(2009) Steven E. Kauder et al.   PLoS Pathogens

Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses

(2008) F. Groot et al.   BLOOD

HIV-1-Tat potentiates CXCL12/Stromal Cell-Derived Factor 1-induced downregulation of membrane CXCR4 in T lymphocytes through Protein kinase C zeta

(2008) Alicia M. Hidalgo-Estévez et al.   MOLECULAR IMMUNOLOGY

Transient-mediated fate determination in a transcriptional circuit of HIV

(2008) Leor S Weinberger et al.   NATURE GENETICS