Leveraging Novel Integrated Single-Cell Analyses to Define HIV-1 Latency Reversal
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Title
Leveraging Novel Integrated Single-Cell Analyses to Define HIV-1 Latency Reversal
Authors
Keywords
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Journal
Viruses-Basel
Volume 13, Issue 7, Pages 1197
Publisher
MDPI AG
Online
2021-06-23
DOI
10.3390/v13071197
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Note: Only part of the references are listed.- Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens
- (2021) Efthymia Papalexi et al. NATURE GENETICS
- Integrated analysis of multimodal single-cell data
- (2021) Yuhan Hao et al. CELL
- Inference and effects of barcode multiplets in droplet-based single-cell assays
- (2020) Caleb A. Lareau et al. Nature Communications
- Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target
- (2020) Runxia Liu et al. Science Translational Medicine
- Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling
- (2020) Caleb A. Lareau et al. NATURE BIOTECHNOLOGY
- Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA
- (2020) Francesco R. Simonetti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin
- (2020) Sai Ma et al. CELL
- Distinct viral reservoirs in individuals with spontaneous control of HIV-1
- (2020) Chenyang Jiang et al. NATURE
- Persistence of an intact HIV reservoir in phenotypically naive T cells
- (2020) Emmanuele Venanzi Rullo et al. JCI Insight
- Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection
- (2019) Marion Pardons et al. PLoS Pathogens
- Entry of Polarized Effector Cells into Quiescence Forces HIV Latency
- (2019) Curtis Dobrowolski et al. mBio
- Integrative single-cell analysis
- (2019) Tim Stuart et al. NATURE REVIEWS GENETICS
- A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
- (2019) Katherine M. Bruner et al. NATURE
- Naïve CD4+ T Cells Harbor a Large Inducible Reservoir of Latent, Replication-Competent HIV-1
- (2019) Jennifer M Zerbato et al. CLINICAL INFECTIOUS DISEASES
- Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells
- (2019) Eleni P. Mimitou et al. NATURE METHODS
- Comprehensive Integration of Single-Cell Data
- (2019) Tim Stuart et al. CELL
- Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity
- (2019) Joshua D. Welch et al. CELL
- Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART
- (2019) Nadine Bachmann et al. Nature Communications
- Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations
- (2019) Judith Grau-Expósito et al. PLoS Pathogens
- Fast, sensitive and accurate integration of single-cell data with Harmony
- (2019) Ilya Korsunsky et al. NATURE METHODS
- Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease
- (2019) Peter A. Szabo et al. Nature Communications
- Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals
- (2019) Elizabeth R. Wonderlich et al. PLoS Pathogens
- M3S: a comprehensive model selection for multi-modal single-cell RNA sequencing data
- (2019) Yu Zhang et al. BMC BIOINFORMATICS
- CD4+ T Cell Subsets and Pathways to HIV Latency
- (2018) Luis M. Agosto et al. AIDS RESEARCH AND HUMAN RETROVIRUSES
- Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation
- (2018) Jason D. Buenrostro et al. CELL
- PBMC fixation and processing for Chromium single-cell RNA sequencing
- (2018) Jinguo Chen et al. Journal of Translational Medicine
- Integrating single-cell transcriptomic data across different conditions, technologies, and species
- (2018) Andrew Butler et al. NATURE BIOTECHNOLOGY
- Genetic determinants of co-accessible chromatin regions in activated T cells across humans
- (2018) Rachel E. Gate et al. NATURE GENETICS
- Transcript-indexed ATAC-seq for precision immune profiling
- (2018) Ansuman T. Satpathy et al. NATURE MEDICINE
- Clonal CD4+ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation
- (2018) Lillian B. Cohn et al. NATURE MEDICINE
- Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise
- (2018) Johann Plantin et al. Retrovirology
- Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding
- (2018) Alexander B. Rosenberg et al. SCIENCE
- HIV latency in isolated patient CD4 + T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing
- (2018) Steven A. Yukl et al. Science Translational Medicine
- scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells
- (2018) Stephen J. Clark et al. Nature Communications
- Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-Infected Cells
- (2018) Monica Golumbeanu et al. Cell Reports
- A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility
- (2018) Darren A. Cusanovich et al. CELL
- Conflicting evidence for HIV enrichment in CD32+ CD4 T cells
- (2018) Liliana Pérez et al. NATURE
- The role of CD32 during HIV-1 infection
- (2018) Lynn N. Bertagnolli et al. NATURE
- Evidence that CD32a does not mark the HIV-1 latent reservoir
- (2018) Christa E. Osuna et al. NATURE
- Joint profiling of chromatin accessibility and gene expression in thousands of single cells
- (2018) Junyue Cao et al. SCIENCE
- HIV-1-Infected CD4+ T Cells Facilitate Latent Infection of Resting CD4+ T Cells through Cell-Cell Contact
- (2018) Luis M. Agosto et al. Cell Reports
- Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection
- (2018) José Carlos Valle-Casuso et al. Cell Metabolism
- Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis
- (2018) Haojia Wu et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Single-cell and single-molecule epigenomics to uncover genome regulation at unprecedented resolution
- (2018) Efrat Shema et al. NATURE GENETICS
- A rapid and robust method for single cell chromatin accessibility profiling
- (2018) Xi Chen et al. Nature Communications
- Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral Latency
- (2018) Todd Bradley et al. Cell Reports
- Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency
- (2017) Nancie M. Archin et al. JOURNAL OF CLINICAL INVESTIGATION
- Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells
- (2017) Guinevere Q. Lee et al. JOURNAL OF CLINICAL INVESTIGATION
- Proliferation of latently infected CD4+T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics
- (2017) Nina N. Hosmane et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq
- (2017) Peng Hu et al. MOLECULAR CELL
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- Multiplexed quantification of proteins and transcripts in single cells
- (2017) Vanessa M Peterson et al. NATURE BIOTECHNOLOGY
- Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain
- (2017) Blue B Lake et al. NATURE BIOTECHNOLOGY
- Defining total-body AIDS-virus burden with implications for curative strategies
- (2017) Jacob D Estes et al. NATURE MEDICINE
- chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data
- (2017) Alicia N Schep et al. NATURE METHODS
- Simultaneous epitope and transcriptome measurement in single cells
- (2017) Marlon Stoeckius et al. NATURE METHODS
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- (2017) Naomi Habib et al. NATURE METHODS
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- (2017) Vijay Ramani et al. NATURE METHODS
- Comprehensive single-cell transcriptional profiling of a multicellular organism
- (2017) Junyue Cao et al. SCIENCE
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- (2017) Bonnie Hiener et al. Cell Reports
- Levels of HIV-1 persistence on antiretroviral therapy are not associated with markers of inflammation or activation
- (2017) Rajesh T. Gandhi et al. PLoS Pathogens
- Simultaneous measurement of chromatin accessibility, DNA methylation, and nucleosome phasing in single cells
- (2017) Sebastian Pott eLife
- Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy
- (2016) Carolina Gutiérrez et al. AIDS
- On the Dependency of Cellular Protein Levels on mRNA Abundance
- (2016) Yansheng Liu et al. CELL
- Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+T CellsIn Vitro
- (2016) Jennifer M. Zerbato et al. JOURNAL OF VIROLOGY
- Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution
- (2016) M Ryan Corces et al. NATURE GENETICS
- Defective proviruses rapidly accumulate during acute HIV-1 infection
- (2016) Katherine M Bruner et al. NATURE MEDICINE
- T cell fate and clonality inference from single-cell transcriptomes
- (2016) Michael J T Stubbington et al. NATURE METHODS
- HiChIP: efficient and sensitive analysis of protein-directed genome architecture
- (2016) Maxwell R Mumbach et al. NATURE METHODS
- Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy
- (2016) Hiromi Imamichi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nuclear RNA-seq of single neurons reveals molecular signatures of activation
- (2016) Benjamin Lacar et al. Nature Communications
- A non-negative matrix factorization method for detecting modules in heterogeneous omics multi-modal data
- (2015) Zi Yang et al. BIOINFORMATICS
- Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells
- (2015) Allon M. Klein et al. CELL
- Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
- (2015) Evan Z. Macosko et al. CELL
- Single-cell chromatin accessibility reveals principles of regulatory variation
- (2015) Jason D. Buenrostro et al. NATURE
- Spatial reconstruction of single-cell gene expression data
- (2015) Rahul Satija et al. NATURE BIOTECHNOLOGY
- Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state
- (2015) Assaf Rotem et al. NATURE BIOTECHNOLOGY
- Computational and analytical challenges in single-cell transcriptomics
- (2015) Oliver Stegle et al. NATURE REVIEWS GENETICS
- Multiplex single-cell profiling of chromatin accessibility by combinatorial cellular indexing
- (2015) D. A. Cusanovich et al. SCIENCE
- The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo
- (2015) Ole S. Søgaard et al. PLoS Pathogens
- A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals
- (2015) Francesco Andrea Procopio et al. EBioMedicine
- Antiretroviral-Free HIV-1 Remission and Viral Rebound After Allogeneic Stem Cell Transplantation
- (2014) Timothy J. Henrich et al. ANNALS OF INTERNAL MEDICINE
- Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment
- (2014) Jim R Hughes et al. NATURE GENETICS
- Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy
- (2014) A. R. Cillo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1
- (2014) Alison L. Hill et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Screening for noise in gene expression identifies drug synergies
- (2014) R. D. Dar et al. SCIENCE
- Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types
- (2014) D. A. Jaitin et al. SCIENCE
- Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial
- (2014) Thomas A Rasmussen et al. Lancet HIV
- Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure
- (2013) Ya-Chi Ho et al. CELL
- Single-cell Hi-C reveals cell-to-cell variability in chromosome structure
- (2013) Takashi Nagano et al. NATURE
- Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
- (2013) Jason D Buenrostro et al. NATURE METHODS
- RNA-sequencing from single nuclei
- (2013) R. V. Grindberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HIV Latency
- (2013) R. F. Siliciano et al. Cold Spring Harbor Perspectives in Medicine
- Rapid Quantification of the Latent Reservoir for HIV-1 Using a Viral Outgrowth Assay
- (2013) Gregory M. Laird et al. PLoS Pathogens
- Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells
- (2012) Daniel Ramsköld et al. NATURE BIOTECHNOLOGY
- A Flexible Model of HIV-1 Latency Permitting Evaluation of Many Primary CD4 T-Cell Reservoirs
- (2012) Kara G. Lassen et al. PLoS One
- Tumour evolution inferred by single-cell sequencing
- (2011) Nicholas Navin et al. NATURE
- Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors
- (2009) Nancie M Archin et al. AIDS
- HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
- (2009) Nicolas Chomont et al. NATURE MEDICINE
- mRNA-Seq whole-transcriptome analysis of a single cell
- (2009) Fuchou Tang et al. NATURE METHODS
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