Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection

(2019) Marion Pardons et al.   PLoS Pathogens

Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion

(2019) Marilia Rita Pinzone et al.   Nature Communications

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

(2019) Katherine M. Bruner et al.   NATURE

CD4+ T Cell Subsets and Pathways to HIV Latency

(2018) Luis M. Agosto et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells

(2018) Mohamed Abdel-Mohsen et al.   Science Translational Medicine

Relationship between Measures of HIV Reactivation and Decline of the Latent Reservoir under Latency-Reversing Agents

(2017) Janka Petravic et al.   JOURNAL OF VIROLOGY

A Novel Single-Cell FISH-Flow Assay Identifies Effector Memory CD4 + T cells as a Major Niche for HIV-1 Transcription in HIV-Infected Patients

(2017) Judith Grau-Expósito et al.   mBio

Benzotriazoles Reactivate Latent HIV-1 through Inactivation of STAT5 SUMOylation

(2017) Alberto Bosque et al.   Cell Reports

Modeling Kick-Kill Strategies toward HIV Cure

(2017) Esteban A. Hernandez-Vargas   Frontiers in Immunology

Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy

(2016) Carolina Gutiérrez et al.   AIDS

Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals

(2016) Amy E. Baxter et al.   Cell Host & Microbe

Modulation of apoptosis and viral latency – an axis to be well understood for successful cure of human immunodeficiency virus

(2016) Uddhav Timilsina et al.   JOURNAL OF GENERAL VIROLOGY

Kinetics of HIV-1 Latency Reversal Quantified on the Single-Cell Level Using a Novel Flow-Based Technique

(2016) G. Martrus et al.   JOURNAL OF VIROLOGY

Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC): a single-arm, phase 1B/2A trial

(2016) Steffen Leth et al.   Lancet HIV

Short Communication: Apoptosis Pathways in HIV-1-Infected Patients Before and After Highly Active Antiretroviral Therapy: Relevance to Immune Recovery

(2015) David L. Pitrak et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

(2015) Gregory M. Laird et al.   JOURNAL OF CLINICAL INVESTIGATION

In VitroReactivation of Replication-Competent and Infectious HIV-1 by Histone Deacetylase Inhibitors

(2015) Riddhima Banga et al.   JOURNAL OF VIROLOGY

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

(2015) Ole S. Søgaard et al.   PLoS Pathogens

A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals

(2015) Francesco Andrea Procopio et al.   EBioMedicine

Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ–NF-κB signaling

(2014) Guochun Jiang et al.   AIDS

Long-Term Antiretroviral Treatment Initiated at Primary HIV-1 Infection Affects the Size, Composition, and Decay Kinetics of the Reservoir of HIV-1-Infected CD4 T Cells

(2014) M. J. Buzon et al.   JOURNAL OF VIROLOGY

HIV-1 persistence in CD4+ T cells with stem cell–like properties

(2014) Maria J Buzon et al.   NATURE MEDICINE

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Heat shock protein 90 controls HIV-1 reactivation from latency

(2014) I. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy

(2014) A. R. Cillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactivation of latent HIV-1 by new semi-synthetic ingenol esters

(2014) Diego Pandeló José et al.   VIROLOGY

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

(2014) Datsen George Wei et al.   PLoS Pathogens

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

(2014) Thomas A Rasmussen et al.   Lancet HIV

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1-Infected Adults on Antiretroviral Therapy

(2013) A. M. Spivak et al.   CLINICAL INFECTIOUS DISEASES

Assessing main death pathways in T lymphocytes from HIV infected individuals

(2013) Marta Massanella et al.   CYTOMETRY PART A

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

Phenotypic and Functional Profiling of CD4 T Cell Compartment in Distinct Populations of Healthy Adults with Different Antigenic Exposure

(2013) Sophie Roetynck et al.   PLoS One

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

(2013) Celsa A. Spina et al.   PLoS Pathogens

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Shock and kill

(2012) Steven G. Deeks   NATURE

The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation

(2012) Zichong Li et al.   NUCLEIC ACIDS RESEARCH

HIV reservoirs and the possibility of a cure for HIV infection

(2011) S. Palmer et al.   JOURNAL OF INTERNAL MEDICINE

HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals

(2010) D. Trono et al.   SCIENCE

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs

(2009) Mayte Coiras et al.   NATURE REVIEWS MICROBIOLOGY

The Challenge of Finding a Cure for HIV Infection

(2009) D. D. Richman et al.   SCIENCE