Remodeling tumor microenvironment with nanomedicines

Efficacy of pH-Sensitive Nanomedicines in Tumors with Different c-MYC Expression Depends on the Intratumoral Activation Profile

(2021) Hitoshi Shibasaki et al.   ACS Nano

Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

(2021) Yang Chen et al.   CANCER CELL

Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

(2020) John D. Martin et al.   Nature Reviews Clinical Oncology

Combining microenvironment normalization strategies to improve cancer immunotherapy

(2020) Fotios Mpekris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement Activation: A Potential Threat on the Safety of Poly(ethylene glycol)-Coated Nanomedicines

(2020) Alberto Gabizon et al.   ACS Nano

Translational Nanomedicine Boosts Anti-PD1 Therapy to Eradicate Orthotopic PTEN-Negative Glioblastoma

(2020) Hiroaki Kinoh et al.   ACS Nano

Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals

(2020) Gergely Tibor Kozma et al.   ADVANCED DRUG DELIVERY REVIEWS

Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix

(2020) Honglin Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma

(2020) Eric Van Cutsem et al.   JOURNAL OF CLINICAL ONCOLOGY

Impact of Pre-Existing or Induced Anti-PEG IgM on the Pharmacokinetics of Peginterferon Alfa-2a (Pegasys) in Mice

(2020) Nehal E. Elsadek et al.   MOLECULAR PHARMACEUTICS

Comparing nanoparticle polymeric micellar paclitaxel and solvent-based paclitaxel as first-line treatment of advanced non-small-cell lung cancer: an open-label, randomized, multicenter, phase III trial

(2020) M. Shi et al.   ANNALS OF ONCOLOGY

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

(2019) Daniel Shae et al.   Nature Nanotechnology

Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer

(2019) Ivy X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Stroma: A Tale of Caution

(2019) Andrea Wang-Gillam   JOURNAL OF CLINICAL ONCOLOGY

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges

(2019) John D. Martin et al.   Annual Review of Physiology

Regulation of Blood and Lymphatic Vessels by Immune Cells in Tumors and Metastasis

(2019) Massimiliano Mazzone et al.   Annual Review of Physiology

Tailoring Nanomaterials for Targeting Tumor‐Associated Macrophages

(2019) Muhammad Ovais et al.   ADVANCED MATERIALS

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors

(2019) Kazumi Suzuki et al.   JOURNAL OF CONTROLLED RELEASE

Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy

(2019) Vikash P. Chauhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer

(2019) Janet E. Murphy et al.   JAMA Oncology

Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse models

(2019) Walid S. Kamoun et al.   Nature Biomedical Engineering

Dexamethasone Increases Cisplatin-Loaded Nanocarrier Delivery and Efficacy in Metastatic Breast Cancer by Normalizing the Tumor Microenvironment

(2019) John D. Martin et al.   ACS Nano

Ligand density on nanoparticles: A parameter with critical impact on nanomedicine

(2019) Alaaldin M. Alkilany et al.   ADVANCED DRUG DELIVERY REVIEWS

Ligand‐Installed Nanocarriers toward Precision Therapy

(2019) Peng Mi et al.   ADVANCED MATERIALS

PEGylated liposomes: immunological responses

(2019) Marwa Mohamed et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Dual PD ‐1 and VEGFR ‐2 blockade promotes vascular normalization and enhances anti‐tumor immune responses in HCC

(2019) Kohei Shigeta et al.   HEPATOLOGY

CTLA4 blockade promotes vessel normalization in breast tumors via the accumulation of eosinophils

(2019) Xichen Zheng et al.   INTERNATIONAL JOURNAL OF CANCER

Radiation and Heat Improve the Delivery and Efficacy of Nanotherapeutics by Modulating Intratumoral Fluid Dynamics

(2018) Shawn Stapleton et al.   ACS Nano

Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy

(2018) Jun Zhao et al.   BIOMATERIALS

LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody–Drug Conjugates

(2018) James W. Purcell et al.   CANCER RESEARCH

Block Copolymer Micelles in Nanomedicine Applications

(2018) Horacio Cabral et al.   CHEMICAL REVIEWS

Magnetic Resonance Imaging of Tumor-Associated Macrophages: Clinical Translation

(2018) Maryam Aghighi et al.   CLINICAL CANCER RESEARCH

Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity

(2018) Yuan Zhang et al.   Nature Communications

Stromal Modulation Reverses Primary Resistance to Immune Checkpoint Blockade in Pancreatic Cancer

(2018) Jun Zhao et al.   ACS Nano

Impact of Baseline Steroids on Efficacy of Programmed Cell Death-1 and Programmed Death-Ligand 1 Blockade in Patients With Non–Small-Cell Lung Cancer

(2018) Kathryn C. Arbour et al.   JOURNAL OF CLINICAL ONCOLOGY

Nanoparticle‐Laden Macrophages for Tumor‐Tropic Drug Delivery

(2018) Weizhong Zhang et al.   ADVANCED MATERIALS

Epirubicin-loaded polymeric micelles effectively treat axillary lymph nodes metastasis of breast cancer through selective accumulation and pH-triggered drug release

(2018) Tsukasa Chida et al.   JOURNAL OF CONTROLLED RELEASE

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium

(2018) Giorgio Seano et al.   Nature Biomedical Engineering

Nanomedicine Strategies to Target Tumor-Associated Macrophages

(2017) Karin Binnemars-Postma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer

(2017) Xiangsheng Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors

(2017) S. Quader et al.   JOURNAL OF CONTROLLED RELEASE

cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells

(2017) Kazuki Miyano et al.   JOURNAL OF CONTROLLED RELEASE

Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy

(2017) Fotios Mpekris et al.   JOURNAL OF CONTROLLED RELEASE

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteasome Inhibitor–Loaded Micelles Enhance Antitumor Activity Through Macrophage Reprogramming by NF-κB Inhibition

(2017) Hailiang Wu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming

(2017) Lin Tian et al.   NATURE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Tumour heterogeneity and resistance to cancer therapies

(2017) Ibiayi Dagogo-Jack et al.   Nature Reviews Clinical Oncology

Role of vascular normalization in benefit from metronomic chemotherapy

(2017) Fotios Mpekris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conjugation of gold nanoparticles and recombinant human endostatin modulates vascular normalization via interruption of anterior gradient 2–mediated angiogenesis

(2017) Fan Pan et al.   TUMOR BIOLOGY

Pirfenidone normalizes the tumor microenvironment to improve chemotherapy

(2017) Christiana Polydorou et al.   Oncotarget

Development of Sialic Acid-coated Nanoparticles for Targeting Cancer and Efficient Evasion of the Immune System

(2017) Young-Hwa Kim et al.   Theranostics

Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner

(2017) Panagiotis Papageorgis et al.   Scientific Reports

The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors

(2016) Lei Miao et al.   ACS Nano

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

(2016) Bing-Mae Chen et al.   ANALYTICAL CHEMISTRY

Tumor priming using metronomic chemotherapy with neovasculature-targeted, nanoparticulate paclitaxel

(2016) Xin Luan et al.   BIOMATERIALS

Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors

(2016) Lei Miao et al.   CANCER RESEARCH

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis

(2016) Mathias Wenes et al.   Cell Metabolism

A tenascin C targeted nanoliposome with navitoclax for specifically eradicating of cancer-associated fibroblasts

(2016) Binlong Chen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery

(2016) Yu Matsumoto et al.   Nature Nanotechnology

A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma

(2016) Andrew H. Ko et al.   PANCREAS

Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages

(2016) Teresa E. Peterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

(2016) Jonas Kloepper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix stiffening promotes a tumor vasculature phenotype

(2016) Francois Bordeleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploiting macrophages as targeted carrier to guide nanoparticles into glioma

(2016) Liang Pang et al.   Oncotarget

Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity

(2016) John D. Martin et al.   Cold Spring Harbor Perspectives in Medicine

Solid stress and elastic energy as measures of tumour mechanopathology

(2016) Hadi T. Nia et al.   Nature Biomedical Engineering

Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers

(2015) Horacio Cabral et al.   ACS Nano

Aptamer Nanomedicine for Cancer Therapeutics: Barriers and Potential for Translation

(2015) Yeh-Hsing Lao et al.   ACS Nano

Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer

(2015) Jooyeon Ahn et al.   BIOMATERIALS

Tumortropic monocyte-mediated delivery of echogenic polymer bubbles and therapeutic vesicles for chemotherapy of tumor hypoxia

(2015) Wen-Chia Huang et al.   BIOMATERIALS

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

Orchestrating the Tumor Microenvironment to Improve Survival for Patients With Pancreatic Cancer

(2015) Clifford J. Whatcott et al.   CANCER JOURNAL

Nanoparticle modulation of the tumor microenvironment enhances therapeutic efficacy of cisplatin

(2015) Lei Miao et al.   JOURNAL OF CONTROLLED RELEASE

Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

(2015) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8+ T cells

(2015) Rafael Carretero et al.   NATURE IMMUNOLOGY

Principles in the design of ligand-targeted cancer therapeutics and imaging agents

(2015) Madduri Srinivasarao et al.   NATURE REVIEWS DRUG DISCOVERY

Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer

(2015) Rebecca S. Heist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients

(2015) Sara M. Tolaney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug

(2015) Miles A. Miller et al.   Nature Communications

Bundled Assembly of Helical Nanostructures in Polymeric Micelles Loaded with Platinum Drugs Enhancing Therapeutic Efficiency against Pancreatic Tumor

(2014) Yuki Mochida et al.   ACS Nano

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

Selective eradication of tumor vascular pericytes by peptide-conjugated nanoparticles for antiangiogenic therapy of melanoma lung metastasis

(2014) Ying-Yun Guan et al.   BIOMATERIALS

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

CD14 Influences Host Immune Responses and Alternative Activation of Macrophages during Schistosoma mansoni Infection

(2014) Smanla Tundup et al.   INFECTION AND IMMUNITY

Enhanced primary tumor delineation in pancreatic adenocarcinoma using ultrasmall super paramagnetic iron oxide nanoparticle-ferumoxytol: an initial experience with histopathologic correlation

(2014) Sandeep Hedgire et al.   International Journal of Nanomedicine

EPR: Evidence and fallacy

(2014) Joseph W. Nichols et al.   JOURNAL OF CONTROLLED RELEASE

Polymeric micelles loaded with platinum anticancer drugs target preangiogenic micrometastatic niches associated with inflammation

(2014) Hailiang Wu et al.   JOURNAL OF CONTROLLED RELEASE

Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe

(2014) E. Phillips et al.   Science Translational Medicine

Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients

(2014) Michael S Hershfield et al.   ARTHRITIS RESEARCH & THERAPY

Cyclic RGD-Linked Polymeric Micelles for Targeted Delivery of Platinum Anticancer Drugs to Glioblastoma through the Blood–Brain Tumor Barrier

(2013) Yutaka Miura et al.   ACS Nano

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Coevolution of Solid Stress and Interstitial Fluid Pressure in Tumors During Progression: Implications for Vascular Collapse

(2013) Triantafyllos Stylianopoulos et al.   CANCER RESEARCH

Targeting Placental Growth Factor/Neuropilin 1 Pathway Inhibits Growth and Spread of Medulloblastoma

(2013) Matija Snuderl et al.   CELL

Tumor Stromal Architecture Can Define the Intrinsic Tumor Response to VEGF-Targeted Therapy

(2013) N. R. Smith et al.   CLINICAL CANCER RESEARCH

Tumor perfusion imaging predicts the intra-tumoral accumulation of liposomes

(2013) Shawn Stapleton et al.   JOURNAL OF CONTROLLED RELEASE

Phenylboronic Acid-Installed Polymeric Micelles for Targeting Sialylated Epitopes in Solid Tumors

(2013) Stephanie Deshayes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression

(2013) Shom Goel et al.   JNCI-Journal of the National Cancer Institute

Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers

(2013) Theofilus A. Tockary et al.   MACROMOLECULES

Strategies for advancing cancer nanomedicine

(2013) Vikash P. Chauhan et al.   NATURE MATERIALS

Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation

(2013) T. T. Batchelor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combining two strategies to improve perfusion and drug delivery in solid tumors

(2013) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

(2013) P. L. Rodriguez et al.   SCIENCE

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

(2013) Vikash P. Chauhan et al.   Nature Communications

Liposome-like nanostructures for drug delivery

(2013) Weiwei Gao et al.   Journal of Materials Chemistry B

Protein corona formation around nanoparticles – from the past to the future

(2013) Pablo del Pino et al.   Materials Horizons

Targeted Polymeric Micelles for siRNA Treatment of Experimental Cancer by Intravenous Injection

(2012) R. James Christie et al.   ACS Nano

A Phenylboronate-Functionalized Polyion Complex Micelle for ATP-Triggered Release of siRNA

(2012) Mitsuru Naito et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PET imaging of tumor associated macrophages using mannose coated 64Cu liposomes

(2012) Landon W. Locke et al.   BIOMATERIALS

Use of macrophages to deliver therapeutic and imaging contrast agents to tumors

(2012) Jinhyang Choi et al.   BIOMATERIALS

Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway

(2012) Vesselina G. Cooke et al.   CANCER CELL

Antibody-Conjugated Nanoparticles for Therapeutic Applications

(2012) M. M. Cardoso et al.   CURRENT MEDICINAL CHEMISTRY

Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents

(2012) Ricardo P Garay et al.   Expert Opinion on Drug Delivery

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

Efficient intracellular drug-targeting of macrophages using stealth liposomes directed to the hemoglobin scavenger receptor CD163

(2012) Anders Etzerodt et al.   JOURNAL OF CONTROLLED RELEASE

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting

(2012) Hiroshi MAEDA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

(2012) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-  blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma

(2012) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudoprogression of Glioblastoma after Chemo- and Radiation Therapy: Diagnosis by Using Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging with Ferumoxytol versus Gadoteridol and Correlation with Survival

(2012) Seymur Gahramanov et al.   RADIOLOGY

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

(2011) A. G. Sorensen et al.   CANCER RESEARCH

Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues

(2011) Yasutaka Anraku et al.   CHEMICAL COMMUNICATIONS

Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages

(2011) P. Allavena et al.   Clinical & Developmental Immunology

Cell-mediated drug delivery

(2011) Elena V Batrakova et al.   Expert Opinion on Drug Delivery

In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy

(2011) Takahiro Nomoto et al.   JOURNAL OF CONTROLLED RELEASE

Selective Therapeutic Targeting of the Anaplastic Lymphoma Kinase With Liposomal siRNA Induces Apoptosis and Inhibits Angiogenesis in Neuroblastoma

(2011) Daniela Di Paolo et al.   MOLECULAR THERAPY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

(2011) B. Diop-Frimpong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaling rules for diffusive drug delivery in tumor and normal tissues

(2011) James W. Baish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis

(2010) Lei Sun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Legumain Protease-Activated Auristatin Prodrugs Suppress Tumor Growth and Metastasis without Toxicity

(2010) Krishna Mohan Bajjuri  et al.   ChemMedChem

Phenotypic and functional switch of macrophages induced by regulatory CD4+ CD25+ T cells in mice

(2010) Guangwei Liu et al.   IMMUNOLOGY AND CELL BIOLOGY

Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma

(2010) Monica Loi et al.   JOURNAL OF CONTROLLED RELEASE

Antiangiogenic Gene Therapy of Solid Tumor by Systemic Injection of Polyplex Micelles Loading Plasmid DNA Encoding Soluble Flt-1

(2010) Makoto Oba et al.   MOLECULAR PHARMACEUTICS

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Folate Receptor   Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages

(2009) A. Puig-Kroger et al.   CANCER RESEARCH

Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity

(2009) Jia Hu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer

(2009) Seymour   INTERNATIONAL JOURNAL OF ONCOLOGY

Mediating Tumor Targeting Efficiency of Nanoparticles Through Design

(2009) Steven D. Perrault et al.   NANO LETTERS

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Protein-nanoparticle interactions

(2008) Iseult Lynch et al.   Nano Today

Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs

(2007) Ravi V. J. Chari   ACCOUNTS OF CHEMICAL RESEARCH