NLRP3 inflammasomes that induce antitumor immunity

Gasdermin D pore structure reveals preferential release of mature interleukin-1

(2021) Shiyu Xia et al.   NATURE

Select hyperactivating NLRP3 ligands enhance the TH1- and TH17-inducing potential of human type 2 conventional dendritic cells

(2021) Lukas Hatscher et al.   Science Signaling

Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes

(2021) Kohsuke Tsuchiya et al.   Cell Reports

Lactate dehydrogenase: a marker of diminished antitumor immunity

(2020) Sandra Van Wilpe et al.   OncoImmunology

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming

(2020) Margaret M. McDaniel et al.   Cell Reports

A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling

(2020) Carlos A. Donado et al.   Cell Reports

Dendritic Cells and Immunogenic Cancer Cell Death: A Combination for Improving Antitumor Immunity

(2020) María Julia Lamberti et al.   Pharmaceutics

Inflammasomes as Targets for Adjuvants

(2020) Konstantin Ivanov et al.   Pathogens

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

(2019) Ziv Erlich et al.   NATURE IMMUNOLOGY

Inflammasomes: Threat-Assessment Organelles of the Innate Immune System

(2019) Charles L. Evavold et al.   IMMUNITY

Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells

(2019) Ping-Hsien Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of pyroptosis in cancer: pro-cancer or pro-“host”?

(2019) Xiaojing Xia et al.   Cell Death & Disease

Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation

(2019) Marco Di Gioia et al.   NATURE IMMUNOLOGY

Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms

(2019) Jinlong Wei et al.   Oxidative Medicine and Cellular Longevity

NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

(2019) Nour Ershaid et al.   Nature Communications

The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses

(2018) Ewa Oleszycka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

(2018) Aakanksha Jain et al.   Nature Communications

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

(2018) Mercedes Monteleone et al.   Cell Reports

The role of cellular reactive oxygen species in cancer chemotherapy

(2018) Haotian Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals

(2018) Surojit Sarkar et al.   JOURNAL OF IMMUNOLOGY

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Pleiotropic effects of oxidized phospholipids

(2017) Valery Bochkov et al.   FREE RADICAL BIOLOGY AND MEDICINE

By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation

(2017) Ivan Zanoni et al.   IMMUNITY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

(2016) Andrea J. Wolf et al.   CELL

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

Vaccine adjuvants as potential cancer immunotherapeutics

(2016) Burcu Temizoz et al.   INTERNATIONAL IMMUNOLOGY

Hypomethylating agent combination strategies in myelodysplastic syndromes: hopes and shortcomings

(2016) Brian Ball et al.   LEUKEMIA & LYMPHOMA

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Overall survival of cancer patients with serum lactate dehydrogenase greater than 1000 IU/L

(2016) Rujiao Liu et al.   TUMOR BIOLOGY

Potent response of QS-21 as a vaccine adjuvant in the skin when delivered with the Nanopatch, resulted in adjuvant dose sparing

(2016) Hwee-Ing Ng et al.   Scientific Reports

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants

(2015) Robyn Marty-Roix et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells

(2015) Ole Audun Werner Haabeth et al.   OncoImmunology

Signaling through the Adaptor Molecule MyD88 in CD4+ T Cells Is Required to Overcome Suppression by Regulatory T Cells

(2014) Dominik Schenten et al.   IMMUNITY

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

(2014) Kaiwen W. Chen et al.   Cell Reports

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells

(2013) Shlomo Z. Ben-Sasson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Exploiting the Mutanome for Tumor Vaccination

(2012) J. C. Castle et al.   CANCER RESEARCH

CD19+CD1d+CD5+ B cell frequencies are increased in patients with tuberculosis and suppress Th17 responses

(2012) Mingxia Zhang et al.   CELLULAR IMMUNOLOGY

The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses

(2012) Andres Mori et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammasomes in carcinogenesis and anticancer immune responses

(2012) Laurence Zitvogel et al.   NATURE IMMUNOLOGY

Pivotal Role of Innate and Adaptive Immunity in Anthracycline Chemotherapy of Established Tumors

(2011) S. R. Mattarollo et al.   CANCER RESEARCH

IL-1  and IL-1  Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

(2011) P. Rider et al.   JOURNAL OF IMMUNOLOGY

DNA released from dying host cells mediates aluminum adjuvant activity

(2011) Thomas Marichal et al.   NATURE MEDICINE

Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer

(2011) Ole Audun Werner Haabeth et al.   Nature Communications

Staphylococcus aureus Evades Lysozyme-Based Peptidoglycan Digestion that Links Phagocytosis, Inflammasome Activation, and IL-1β Secretion

(2010) Takahiro Shimada et al.   Cell Host & Microbe

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella

(2010) Petr Broz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation

(2010) M. H. Zaki et al.   JOURNAL OF IMMUNOLOGY

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

(2010) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation and Biological Activities of Oxidized Phospholipids

(2009) Valery N. Bochkov et al.   ANTIOXIDANTS & REDOX SIGNALING

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

(2009) S. Z. Ben-Sasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of action of licensed vaccine adjuvants

(2009) Elaine Tritto et al.   VACCINE

Mechanisms and Consequences of Dendritic Cell Migration

(2008) David Alvarez et al.   IMMUNITY

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

(2008) Mirjam Kool et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE