Select hyperactivating NLRP3 ligands enhance the TH1- and TH17-inducing potential of human type 2 conventional dendritic cells

Toward targeting inflammasomes: insights into their regulation and activation

(2020) Shelbi Christgen et al.   CELL RESEARCH

Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming

(2020) Margaret M. McDaniel et al.   Cell Reports

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

(2020) Pierre Bourdely et al.   IMMUNITY

Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection

(2019) Christopher M. Harpur et al.   JOURNAL OF IMMUNOLOGY

Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy

(2019) Thiago A. Patente et al.   Frontiers in Immunology

Inflammasome activation: a monocyte lineage privilege

(2019) Pierre Guermonprez et al.   NATURE IMMUNOLOGY

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

(2019) Ziv Erlich et al.   NATURE IMMUNOLOGY

Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM

(2019) Michael Carty et al.   IMMUNITY

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

MCC950 closes the active conformation of NLRP3 to an inactive state

(2019) Ana Tapia-Abellán et al.   Nature Chemical Biology

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Inflammasomes and autoimmune and rheumatic diseases: A comprehensive review

(2019) Jae Il Shin et al.   JOURNAL OF AUTOIMMUNITY

Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

(2019) Charles-Antoine Dutertre et al.   IMMUNITY

A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication

(2019) Maximilien Grandclaudon et al.   CELL

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

(2019) Chrysothemis C. Brown et al.   CELL

Inflammasome signaling and regulation of interleukin-1 family cytokines

(2019) Amy H. Chan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IRF8 Regulates Transcription of Naip s for NLRC4 Inflammasome Activation

(2018) Rajendra Karki et al.   CELL

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Human dendritic cell subsets: an update

(2018) Matthew Collin et al.   IMMUNOLOGY

Effective Combination Adjuvants Engage Both TLR and Inflammasome Pathways To Promote Potent Adaptive Immune Responses

(2018) Emilie Seydoux et al.   JOURNAL OF IMMUNOLOGY

CLEC10A Is a Specific Marker for Human CD1c+ Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion

(2018) Lukas Heger et al.   Frontiers in Immunology

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

(2018) Mercedes Monteleone et al.   Cell Reports

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Inflammasomes: Emerging Central Players in Cancer Immunology and Immunotherapy

(2018) Dev Karan   Frontiers in Immunology

By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation

(2017) Ivan Zanoni et al.   IMMUNITY

DC subset–specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo

(2017) Christian H.K. Lehmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

(2017) Andrea Stutz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Blood CD1c+Dendritic Cells Encompass CD5highand CD5lowSubsets That Differ Significantly in Phenotype, Gene Expression, and Functions

(2017) Xiangyun Yin et al.   JOURNAL OF IMMUNOLOGY

Nonpyrogenic Molecular Adjuvants Based on norAbu-Muramyldipeptide and norAbu-Glucosaminyl Muramyldipeptide: Synthesis, Molecular Mechanisms of Action, and Biological Activities in Vitro and in Vivo

(2017) Roman Effenberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Different populations of CD11b+ dendritic cells drive Th2 responses in the small intestine and colon

(2017) Johannes U. Mayer et al.   Nature Communications

Human Blood CD1c+ Dendritic Cells Promote Th1 and Th17 Effector Function in Memory CD4+ T Cells

(2017) Ingrid M. Leal Rojas et al.   Frontiers in Immunology

Transcriptional Control of Dendritic Cell Development

(2016) Theresa L. Murphy et al.   Annual Review of Immunology

Expansion of a BDCA1+CD14+ Myeloid Cell Population in Melanoma Patients May Attenuate the Efficacy of Dendritic Cell Vaccines

(2016) G. Bakdash et al.   CANCER RESEARCH

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

(2016) Andrea J. Wolf et al.   CELL

Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion

(2016) S A Conos et al.   CELL DEATH AND DIFFERENTIATION

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c + or CD141 + DCs

(2016) Gaëlle Breton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Comparative Study of the T Cell Stimulatory and Polarizing Capacity of Human Primary Blood Dendritic Cell Subsets

(2016) Simone P. Sittig et al.   MEDIATORS OF INFLAMMATION

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Proteomics of Human Dendritic Cell Subsets Reveals Subset-Specific Surface Markers and Differential Inflammasome Function

(2016) Kuntal Worah et al.   Cell Reports

Klf4 Expression in Conventional Dendritic Cells Is Required for T Helper 2 Cell Responses

(2015) Roxane Tussiwand et al.   IMMUNITY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Immunity to Pathogens Taught by Specialized Human Dendritic Cell Subsets

(2015) Jens Geginat et al.   Frontiers in Immunology

Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming

(2014) M. Dalod et al.   EMBO JOURNAL

Development and Function of Dendritic Cell Subsets

(2014) Alexander Mildner et al.   IMMUNITY

BDCA1-Positive Dendritic Cells (DCs) Represent a Unique Human Myeloid DC Subset That Induces Innate and Adaptive Immune Responses to Staphylococcus aureus Infection

(2014) Jun-O Jin et al.   INFECTION AND IMMUNITY

Applying caspase-1 inhibitors for inflammasome assays in human whole blood

(2014) Katarzyna Lipinska et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Normalization of RNA-seq data using factor analysis of control genes or samples

(2014) Davide Risso et al.   NATURE BIOTECHNOLOGY

The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge

(2014) Kaiwen W. Chen et al.   Cell Reports

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

(2013) G. Nizzoli et al.   BLOOD

Organization of the mouse and human DC network

(2013) Andreas Schlitzer et al.   CURRENT OPINION IN IMMUNOLOGY

Plasmacytoid, conventional, and monocyte-derived dendritic cells undergo a profound and convergent genetic reprogramming during their maturation

(2013) Thien-Phong Vu Manh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation

(2013) Elodie Segura et al.   IMMUNITY

IRF4 Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation

(2013) Emma K. Persson et al.   IMMUNITY

IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

(2013) Andreas Schlitzer et al.   IMMUNITY

Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice

(2013) Payal B Watchmaker et al.   NATURE IMMUNOLOGY

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

(2013) Ansuman T Satpathy et al.   NATURE IMMUNOLOGY

The Dendritic Cell Response to Classic, Emerging, and Homeostatic Danger Signals. Implications for Autoimmunity

(2013) Paul M. Gallo et al.   Frontiers in Immunology

NanoStringNorm: an extensible R package for the pre-processing of NanoString mRNA and miRNA data

(2012) Daryl Waggott et al.   BIOINFORMATICS

Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

(2012) Muzlifah Haniffa et al.   IMMUNITY

NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice

(2012) M. Kovarova et al.   JOURNAL OF IMMUNOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

The Th17 Pathway and Inflammatory Diseases of the Intestines, Lungs, and Skin

(2011) Casey T. Weaver et al.   Annual Review of Pathology-Mechanisms of Disease

Notch2 Receptor Signaling Controls Functional Differentiation of Dendritic Cells in the Spleen and Intestine

(2011) Kanako L. Lewis et al.   IMMUNITY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+dendritic cells

(2010) Karine Crozat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+cells as homologues of mouse CD8+dendritic cells

(2010) Annabell Bachem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse CD8α+DCs and human BDCA3+DCs are major producers of IFN-λ in response to poly IC

(2010) Henning Lauterbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Found in translation: the human equivalent of mouse CD8+dendritic cells: Table I.

(2010) Jose A. Villadangos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

(2010) Edel A. McNeela et al.   PLoS Pathogens

Orchestration of the immune response by dendritic cells

(2009) Matthew R. Buckwalter et al.   CURRENT BIOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Involvement of the NLRP3 Inflammasome in Innate and Humoral Adaptive Immune Responses to Fungal  -Glucan

(2009) H. Kumar et al.   JOURNAL OF IMMUNOLOGY

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells

(2009) Robin R. Craven et al.   PLoS One

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Th17 cells in human disease

(2008) Laura A. Tesmer et al.   IMMUNOLOGICAL REVIEWS

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1  secretion in response to Bacillus anthracis infection and muramyl dipeptide

(2008) L.-C. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

(2008) Scott H Robbins et al.   GENOME BIOLOGY