The Retromer Complex: From Genesis to Revelations

Architecture of Mammalian Retromer by Single Particle Cryo-EM

(2020) Amy K. Kendall et al.   BIOPHYSICAL JOURNAL

Mechanism of cargo recognition by retromer-linked SNX-BAR proteins

(2020) Xin Yong et al.   PLOS BIOLOGY

Retromer forms low order oligomers on supported lipid bilayers

(2020) Catherine L. Deatherage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry

(2020) Jian Xie et al.   Cell Reports

Full recovery of the Alzheimer’s disease phenotype by gain of function of vacuolar protein sorting 35

(2019) Jian-Guo Li et al.   MOLECULAR PSYCHIATRY

A bipartite sorting signal ensures specificity of retromer complex in membrane protein recycling

(2019) Sho W. Suzuki et al.   JOURNAL OF CELL BIOLOGY

A Role for the VPS Retromer in Brucella Intracellular Replication Revealed by Genomewide siRNA Screening

(2019) Alain Casanova et al.   mSphere

Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins

(2019) Boris Simonetti et al.   NATURE CELL BIOLOGY

Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting

(2018) Erin T Williams et al.   HUMAN MOLECULAR GENETICS

Mechanism of inhibition of retromer transport by the bacterial effector RidL

(2018) Jialin Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein

(2018) Jessica E. Young et al.   Stem Cell Reports

Structure of the membrane-assembled retromer coat determined by cryo-electron tomography

(2018) Oleksiy Kovtun et al.   NATURE

Quantitative Yeast Genetic Interaction Profiling of Bacterial Effector Proteins Uncovers a Role for the Human Retromer in Salmonella Infection

(2018) Kristin L. Patrick et al.   Cell Systems

Retromer has a selective function in cargo sorting via endosome transport carriers

(2018) Yi Cui et al.   JOURNAL OF CELL BIOLOGY

Cargo-selective SNX-BAR proteins mediate retromer trimer independent retrograde transport

(2017) Arunas Kvainickas et al.   JOURNAL OF CELL BIOLOGY

Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR

(2017) Boris Simonetti et al.   JOURNAL OF CELL BIOLOGY

Molecular mechanism for the subversion of the retromer coat by theLegionellaeffector RidL

(2017) Miguel Romano-Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retromer and the cation-independent mannose 6-phosphate receptor-Time for a trial separation?

(2017) Matthew N. J. Seaman   TRAFFIC

Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5

(2017) Kevin Bärlocher et al.   Nature Communications

Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction

(2017) Cherilyn A Elwell et al.   eLife

Structural Mechanism for Cargo Recognition by the Retromer Complex

(2016) María Lucas et al.   CELL

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation

(2016) Jordan Follett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atypical parkinsonism–associated retromer mutant alters endosomal sorting of specific cargo proteins

(2016) Kirsty J. McMillan et al.   JOURNAL OF CELL BIOLOGY

SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein

(2016) Timothy Y. Huang et al.   JOURNAL OF NEUROSCIENCE

Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex

(2016) Daniela Chmiest et al.   Nature Communications

Structural and mechanistic insights into regulation of the retromer coat by TBC1d5

(2016) Da Jia et al.   Nature Communications

Retromer and sorting nexins in endosomal sorting

(2015) Matthew Gallon et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection

(2015) Kathleen M. Mirrashidi et al.   Cell Host & Microbe

A role for retromer in hepatitis C virus replication

(2015) Peiqi Yin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

(2015) Christine A. Phillips-Krawczak et al.   MOLECULAR BIOLOGY OF THE CELL

De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease

(2015) A Rovelet-Lecrux et al.   MOLECULAR PSYCHIATRY

Retromer in Alzheimer disease, Parkinson disease and other neurological disorders

(2015) Scott A. Small et al.   NATURE REVIEWS NEUROSCIENCE

Direct Binding of Retromer to Human Papillomavirus Type 16 Minor Capsid Protein L2 Mediates Endosome Exit during Viral Infection

(2015) Andreea Popa et al.   PLoS Pathogens

Genetic variability of the retromer cargo recognition complex in parkinsonism

(2015) Emil K. Gustavsson et al.   MOVEMENT DISORDERS

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation

(2014) Ian J. McGough et al.   CURRENT BIOLOGY

VARP Is Recruited on to Endosomes by Direct Interaction with Retromer, Where Together They Function in Export to the Cell Surface

(2014) Geoffrey G. Hesketh et al.   DEVELOPMENTAL CELL

Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N

(2014) L. N. Munsie et al.   HUMAN MOLECULAR GENETICS

Pharmacological chaperones stabilize retromer to limit APP processing

(2014) Vincent J Mecozzi et al.   Nature Chemical Biology

A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer

(2014) M. Gallon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Insights into Rab7-Mediated Endosomal Recruitment of Core Retromer: Deciphering the Role of Vps26 and Vps35

(2014) Amulya Priya et al.   TRAFFIC

Missing Pieces of an Ancient Puzzle: Evolution of the Eukaryotic Membrane-Trafficking System

(2014) A. Schlacht et al.   Cold Spring Harbor Perspectives in Biology

Retromer: A Master Conductor of Endosome Sorting

(2014) C. Burd et al.   Cold Spring Harbor Perspectives in Biology

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

(2014) Eszter Zavodszky et al.   Nature Communications

Retromer Regulates HIV-1 Envelope Glycoprotein Trafficking and Incorporation into Virions

(2014) Elisabetta Groppelli et al.   PLoS Pathogens

Endosomal recruitment of the WASH complex: Active sequences and mutations impairing interaction with the retromer

(2013) Emmanuèle Helfer et al.   BIOLOGY OF THE CELL

The Legionella Effector RidL Inhibits Retrograde Trafficking to Promote Intracellular Replication

(2013) Ivo Finsel et al.   Cell Host & Microbe

DNAJC13 mutations in Parkinson disease

(2013) Carles Vilariño-Güell et al.   HUMAN MOLECULAR GENETICS

A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport

(2013) Florian Steinberg et al.   NATURE CELL BIOLOGY

A mechanism for retromer endosomal coat complex assembly with cargo

(2013) M. S. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide siRNA screen identifies the retromer as a cellular entry factor for human papillomavirus

(2013) A. Lipovsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer

(2013) Jordan Follett et al.   TRAFFIC

Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing

(2012) A. W. Fjorback et al.   JOURNAL OF NEUROSCIENCE

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer

(2012) Da Jia et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of Alzheimer disease-associated variants in genes that regulate retromer function

(2012) Badri N. Vardarajan et al.   NEUROBIOLOGY OF AGING

Recruitment of the endosomal WASH complex is mediated by the extended ‘tail’ of Fam21 binding to the retromer protein Vps35

(2011) Michael E. Harbour et al.   BIOCHEMICAL JOURNAL

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

(2011) Martin Harterink et al.   NATURE CELL BIOLOGY

SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors

(2011) Paul Temkin et al.   NATURE CELL BIOLOGY

Retromer terminates the generation of cAMP by internalized PTH receptors

(2011) Timothy N Feinstein et al.   Nature Chemical Biology

Vps26A and Vps26B Subunits Define Distinct Retromer Complexes

(2011) Andrea Bugarcic et al.   TRAFFIC

SNX-BAR-Mediated Endosome Tubulation is Co-ordinated with Endosome Maturation

(2011) Jan R.T. van Weering et al.   TRAFFIC

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics

(2010) M. E. Harbour et al.   JOURNAL OF CELL SCIENCE

Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1

(2010) M. Tabuchi et al.   JOURNAL OF CELL SCIENCE

Sorting nexin 8 regulates endosome-to-Golgi transport

(2009) Anne Berit Dyve et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The retromer component SNX6 interacts with dynactin p150Glued and mediates endosome-to-TGN transport

(2009) Zhi Hong et al.   CELL RESEARCH

The Retromer Coat Complex Coordinates Endosomal Sorting and Dynein-Mediated Transport, with Carrier Recognition by the trans-Golgi Network

(2009) Thomas Wassmer et al.   DEVELOPMENTAL CELL

The Arp2/3 Activator WASH Controls the Fission of Endosomes through a Large Multiprotein Complex

(2009) Emmanuel Derivery et al.   DEVELOPMENTAL CELL

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

(2009) Timothy S. Gomez et al.   DEVELOPMENTAL CELL

Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8

(2009) Anbing Shi et al.   EMBO JOURNAL

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

(2009) M. N. J. Seaman et al.   JOURNAL OF CELL SCIENCE

Analysis of Articulation Between Clathrin and Retromer in Retrograde Sorting on Early Endosomes

(2009) Vincent Popoff et al.   TRAFFIC

Retromer Retrieves Wntless

(2008) Suzanne Eaton   DEVELOPMENTAL CELL

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7

(2008) Raul Rojas et al.   JOURNAL OF CELL BIOLOGY

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and A  accumulation

(2008) A. Muhammad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Vps26B and Mapping of its Interaction with the Retromer Protein Complex

(2008) Brett M. Collins et al.   TRAFFIC