Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms

Perfluoroalkyl Acid Binding with Peroxisome Proliferator-Activated Receptors α, γ, and δ, and Fatty Acid Binding Proteins by Equilibrium Dialysis with a Comparison of Methods

(2021) Manoochehr Khazaee et al.   Toxics

Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells

(2020) Anne-Cathrin Behr et al.   ARCHIVES OF TOXICOLOGY

Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness

(2020) Kandice R. Levental et al.   Nature Communications

Association of serum fibroblast growth factor 19 levels with arteriosclerosis parameters assessed by arterial stiffness and atherogenic index of plasma in patients with type 2 diabetes

(2020) Wang-shu Liu et al.   Diabetology & Metabolic Syndrome

Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet

(2020) J.J. Schlezinger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Risk to human health related to the presence of perfluoroalkyl substances in food

(2020) et al.   EFSA Journal

The concentration of several perfluoroalkyl acids in serum appears to be reduced by dietary fiber

(2020) Michael W. Dzierlenga et al.   ENVIRONMENT INTERNATIONAL

Environmental toxicants in breast milk of Norwegian mothers and gut bacteria composition and metabolites in their infants at 1 month

(2019) Nina Iszatt et al.   Microbiome

Bayesian evaluation of a physiologically based pharmacokinetic (PBPK) model for perfluorooctane sulfonate (PFOS) to characterize the interspecies uncertainty between mice, rats, monkeys, and humans: Development and performance verification

(2019) Wei-Chun Chou et al.   ENVIRONMENT INTERNATIONAL

Simultaneous determination of perfluoroalkyl substances and bile acids in human serum using ultra-high-performance liquid chromatography–tandem mass spectrometry

(2019) Samira Salihović et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods

(2019) Patrick D. McMullen et al.   TOXICOLOGY IN VITRO

Tissue distribution of 14C-labelled perfluorooctanoic acid in adult mice after 1–5 days of dietary exposure to an experimental dose or a lower dose that resulted in blood levels similar to those detected in exposed humans

(2019) Jasna Bogdanska et al.   CHEMOSPHERE

Quantitative bias analysis of the association between subclinical thyroid disease and two perfluoroalkyl substances in a single study

(2019) Michael W. Dzierlenga et al.   ENVIRONMENTAL RESEARCH

Activation of human nuclear receptors by perfluoroalkylated substances (PFAS)

(2019) Anne-Cathrin Behr et al.   TOXICOLOGY IN VITRO

Transintestinal cholesterol excretion in humans

(2018) Laurens F. Reeskamp et al.   CURRENT OPINION IN LIPIDOLOGY

Oral contraceptive use as a determinant of plasma concentrations of perfluoroalkyl substances among women in the Norwegian Mother and Child Cohort (MoBa) study

(2018) Elise L. Rush et al.   ENVIRONMENT INTERNATIONAL

Stochastic Pharmacokinetic-Pharmacodynamic Modeling for Assessing the Systemic Health Risk of Perfluorooctanoate (PFOA)

(2018) Matteo Convertino et al.   TOXICOLOGICAL SCIENCES

Molecular Pathways Underlying Cholesterol Homeostasis

(2018) Milessa Silva Afonso et al.   Nutrients

A randomised, double-blind, placebo-controlled phase 1 study of the safety, tolerability and pharmacodynamics of volixibat in overweight and obese but otherwise healthy adults: implications for treatment of non-alcoholic steatohepatitis

(2018) Melissa Palmer et al.   BMC Pharmacology & Toxicology

A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects

(2018) Elsie M. Sunderland et al.   Journal of Exposure Science and Environmental Epidemiology

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

Quantitative bias analysis of a reported association between perfluoroalkyl substances (PFAS) and endometriosis: The influence of oral contraceptive use

(2017) Gerard Ngueta et al.   ENVIRONMENT INTERNATIONAL

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

(2017) Oscar Chávez-Talavera et al.   GASTROENTEROLOGY

Mass Spectrometric Approaches for the Analysis of Phytosterols in Biological Samples

(2017) George Gachumi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Perfluorooctane Sulfonate-Induced Hepatic Steatosis in Male Sprague Dawley Rats Is Not Attenuated by Dietary Choline Supplementation

(2017) Bradford D Bagley et al.   TOXICOLOGICAL SCIENCES

Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis

(2017) Kaberi P. Das et al.   TOXICOLOGY

PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling

(2017) Mitchell B. Rosen et al.   TOXICOLOGY

Physiologically based pharmacokinetic modeling of human exposure to perfluorooctanoic acid suggests historical non drinking-water exposures are important for predicting current serum concentrations

(2017) Rachel Rogers Worley et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Uptake of perfluorooctanoic acid by Caco-2 cells: Involvement of organic anion transporting polypeptides

(2017) Osamu Kimura et al.   TOXICOLOGY LETTERS

Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid

(2016) Taiki Abe et al.   ARCHIVES OF TOXICOLOGY

Total cholesterol as a risk factor for coronary heart disease and stroke in women compared with men: A systematic review and meta-analysis

(2016) Sanne A.E. Peters et al.   ATHEROSCLEROSIS

Mathematically modelling the dynamics of cholesterol metabolism and ageing

(2016) A.E. Morgan et al.   BIOSYSTEMS

A Study of Reverse Causation: Examining the Associations of Perfluorooctanoic Acid Serum Levels with Two Outcomes

(2016) Radhika Dhingra et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Toxicity assessment of perfluorooctane sulfonate using acute and subchronic male C57BL/6J mouse models

(2016) Jiali Xing et al.   ENVIRONMENTAL POLLUTION

Nonalcoholic fatty liver disease severity is associated with the ratios of total cholesterol and triglycerides to high-density lipoprotein cholesterol

(2016) Kuan-Ta Wu et al.   Journal of Clinical Lipidology

Srebp2: A master regulator of sterol and fatty acid synthesis

(2016) Blair B. Madison   JOURNAL OF LIPID RESEARCH

Editor’s Highlight: Perfluorooctane Sulfonate-Choline Ion Pair Formation: A Potential Mechanism Modulating Hepatic Steatosis and Oxidative Stress in Mice

(2016) Limin Zhang et al.   TOXICOLOGICAL SCIENCES

The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction

(2016) Kevin M. Beggs et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Revisiting Human Cholesterol Synthesis and Absorption: The Reciprocity Paradigm and its Key Regulators

(2015) Peter A. S. Alphonse et al.   LIPIDS

Na+/Taurocholate Cotransporting Polypeptide and Apical Sodium-Dependent Bile Acid Transporter Are Involved in the Disposition of Perfluoroalkyl Sulfonates in Humans and Rats

(2015) Wen Zhao et al.   TOXICOLOGICAL SCIENCES

Dose metric considerations in in vitro assays to improve quantitative in vitro–in vivo dose extrapolations

(2015) Floris A. Groothuis et al.   TOXICOLOGY

Application of physiologically-based pharmacokinetic modeling to explore the role of kidney transporters in renal reabsorption of perfluorooctanoic acid in the rat

(2015) Rachel Rogers Worley et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Interaction of perfluoroalkyl acids with human liver fatty acid-binding protein

(2014) Nan Sheng et al.   ARCHIVES OF TOXICOLOGY

Modeled PFOA Exposure and Coronary Artery Disease, Hypertension, and High Cholesterol in Community and Worker Cohorts

(2014) Andrea Winquist et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Enhanced Elimination of Perfluorooctane Sulfonic Acid by Menstruating Women: Evidence from Population-Based Pharmacokinetic Modeling

(2014) Fiona Wong et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Hepatic Mitochondrial Alteration in CD-1 Mice Associated with Prenatal Exposures to Low Doses of Perfluorooctanoic Acid (PFOA)

(2014) Erin M. Quist et al.   TOXICOLOGIC PATHOLOGY

The association between PFOA, PFOS and serum lipid levels in adolescents

(2013) Sarah Dee Geiger et al.   CHEMOSPHERE

Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study

(2013) J. Christopher Corton et al.   CRITICAL REVIEWS IN TOXICOLOGY

Determinants of plasma concentrations of perfluoroalkyl substances in pregnant Norwegian women

(2013) A.L. Brantsæter et al.   ENVIRONMENT INTERNATIONAL

Breastfeeding: A Potential Excretion Route for Mothers and Implications for Infant Exposure to Perfluoroalkyl Acids

(2013) Debapriya Mondal et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Biomonitoring of Perfluoroalkyl Acids in Human Urine and Estimates of Biological Half-Life

(2013) Yifeng Zhang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Evaluation of perfluoroalkyl acid activity using primary mouse and human hepatocytes

(2013) Mitchell B. Rosen et al.   TOXICOLOGY

Circulating microRNA profiles altered in mice after 28d exposure to perfluorooctanoic acid

(2013) Shengmin Yan et al.   TOXICOLOGY LETTERS

A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation

(2012) Mark T Mc Auley et al.   BMC Systems Biology

Development of Pbpk Models for Pfoa and Pfos for Human Pregnancy and Lactation Life Stages

(2012) Anne E. Loccisano et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Regulation of cholesterol homeostasis

(2012) Mariëtte Y.M. van der Wulp et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Lifetime Risks of Cardiovascular Disease

(2012) Jarett D. Berry et al.   NEW ENGLAND JOURNAL OF MEDICINE

Distribution of perfluorooctanesulfonate and perfluorooctanoate into human plasma lipoprotein fractions

(2012) John L. Butenhoff et al.   TOXICOLOGY LETTERS

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

(2011) Wu Yin et al.   JOURNAL OF LIPID RESEARCH

Dermal Penetration Potential of Perfluorooctanoic Acid (PFOA) in Human and Mouse Skin

(2011) Jennifer Franko et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model

(2011) Anne E. Loccisano et al.   REPRODUCTIVE TOXICOLOGY

Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPARα) by perfluoroalkyl acids (PFAAs): Further investigation of C4–C12 compounds

(2011) Cynthia J. Wolf et al.   REPRODUCTIVE TOXICOLOGY

Perfluoroalkyl Sulfonates Cause Alkyl Chain Length–Dependent Hepatic Steatosis and Hypolipidemia Mainly by Impairing Lipoprotein Production in APOE*3-Leiden CETP Mice

(2011) Silvia Bijland et al.   TOXICOLOGICAL SCIENCES

Tissue distribution of 35S-labelled perfluorooctane sulfonate in adult mice after oral exposure to a low environmentally relevant dose or a high experimental dose

(2011) Jasna Bogdanska et al.   TOXICOLOGY

Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes

(2011) J.A. Bjork et al.   TOXICOLOGY

Noncovalent Interactions of Long-Chain Perfluoroalkyl Acids with Serum Albumin

(2010) Heather N. Bischel et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Association of thyroid function with estimated glomerular filtration rate in a population-based study: the HUNT study

(2010) Bjørn Olav Åsvold et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Human detoxification of perfluorinated compounds

(2010) S.J. Genuis et al.   PUBLIC HEALTH

Gene Expression Profiling in Wild-Type and PPAR-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR-Independent Effects

(2010) Mitchell B. Rosen et al.   PPAR Research

Excretion of PFOA and PFOS in Male Rats During a Subchronic Exposure

(2009) Lin Cui et al.   ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

The LDL Receptor

(2009) Joseph L. Goldstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rate of Decline in Serum PFOA Concentrations after Granular Activated Carbon Filtration at Two Public Water Systems in Ohio and West Virginia

(2009) Scott M. Bartell et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Association of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with Uric Acid among Adults with Elevated Community Exposure to PFOA

(2009) Kyle Steenland et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Thirty Years of Medical Surveillance in Perfluooctanoic Acid Production Workers

(2009) Giovanni Costa et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: Toxicokinetics, thyroid hormone status, and related gene expression

(2009) Shu-Ching Chang et al.   REPRODUCTIVE TOXICOLOGY

Pharmacokinetic modeling of perfluorooctanoic acid during gestation and lactation in the mouse

(2009) Chester E. Rodriguez et al.   REPRODUCTIVE TOXICOLOGY

Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor α, but not human PPARα

(2009) Toshiki Nakamura et al.   TOXICOLOGY

Organic anion transporting polypeptide (Oatp) 1a1-mediated perfluorooctanoate transport and evidence for a renal reabsorption mechanism of Oatp1a1 in renal elimination of perfluorocarboxylates in rats

(2009) Ching-Hui Yang et al.   TOXICOLOGY LETTERS

Localization of the Sodium-Taurocholate cotransporting polypeptide in membrane rafts and modulation of its activity by cholesterol in vitro

(2008) Héctor Molina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Perfluorinated compounds – Exposure assessment for the general population in western countries

(2008) Hermann Fromme et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Balancing cholesterol synthesis and absorption in the gastrointestinal tract

(2008) David E. Cohen   Journal of Clinical Lipidology

Evaluation of the Immune System in Rats and Mice Administered Linear Ammonium Perfluorooctanoate

(2008) Scott E. Loveless et al.   TOXICOLOGICAL SCIENCES

Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism

(2007) Sander Kersten   PPAR Research