Interleukin-17 in Liver Disease Pathogenesis

From intestinal dysbiosis to alcohol-associated liver disease

(2020) Beatriz Garcia Mendes et al.   Clinical and Molecular Hepatology

Inflammatory pathways in alcoholic steatohepatitis

(2019) Bin Gao et al.   JOURNAL OF HEPATOLOGY

The IL-17 Family of Cytokines in Health and Disease

(2019) Mandy J. McGeachy et al.   IMMUNITY

Prevalence of Alcoholic Fatty Liver Disease Among Adults in the United States, 2001-2016

(2019) Terrence Wong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease

(2019) Hsiao-Yen Ma et al.   JOURNAL OF HEPATOLOGY

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis

(2018) Katharina Brandl et al.   JOURNAL OF HEPATOLOGY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study

(2018) Elliot B Tapper et al.   BMJ-British Medical Journal

Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study

(2018) Elliot B Tapper et al.   BMJ-British Medical Journal

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

(2018) Ju Youn Kim et al.   CELL

IL-25 protects against high fat diet-induced hepatic steatosis in mice by inducing IL-25 & M2a macrophage production

(2018) Xue-Lian Zheng et al.   IMMUNOLOGY AND CELL BIOLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

(2017) Shabnam Shalapour et al.   NATURE

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling

(2017) Daniel A Giles et al.   NATURE MEDICINE

Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma

(2016) Ana L. Gomes et al.   CANCER CELL

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers

(2016) Genaro R. Villa et al.   CANCER CELL

Is Hepatocellular Cancer the Same Disease in Alcoholic and Nonalcoholic Fatty Liver Diseases?

(2016) Nicolas Goossens et al.   GASTROENTEROLOGY

Investigation of 7-dehydrocholesterol reductase pathway to elucidate off-target prenatal effects of pharmaceuticals: a systematic review

(2016) M R Boland et al.   PHARMACOGENOMICS JOURNAL

Molecular alterations in hepatocellular carcinoma associated with hepatitis B and hepatitis C infections

(2016) Maria Lina Tornesello et al.   Oncotarget

Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis

(2016) Daniel A. Giles et al.   PLoS One

IL-17 Axis Driven Inflammation in Non-Alcoholic Fatty Liver Disease Progression

(2015) Daniel Giles et al.   CURRENT DRUG TARGETS

Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice

(2015) Peng Chen et al.   HEPATOLOGY

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

(2015) Kornelius Schulze et al.   NATURE GENETICS

Understanding the origins of human cancer

(2015) L. B. Alexandrov   SCIENCE

Identification of Functional Roles for Both IL-17RB and IL-17RA in Mediating IL-25-Induced Activities

(2014) E. A. Rickel et al.   JOURNAL OF IMMUNOLOGY

Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth

(2014) V De Simone et al.   ONCOGENE

IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

(2014) Koji Taniguchi et al.   SEMINARS IN IMMUNOLOGY

Eradication of Hepatitis C Virus Infection and the Development of Hepatocellular Carcinoma

(2013) Rebecca L. Morgan et al.   ANNALS OF INTERNAL MEDICINE

Emerging Roles of NUCB2/Nesfatin-1 in the Metabolic Control of Reproduction

(2013) David García-Galiano et al.   CURRENT PHARMACEUTICAL DESIGN

Does interleukin-17 play the villain in nonalcoholic steatohepatitis?

(2013) Tatiana Kisseleva   HEPATOLOGY

IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice

(2013) Isaac T.W. Harley et al.   HEPATOLOGY

IL-17A Plays a Critical Role in the Pathogenesis of Liver Fibrosis through Hepatic Stellate Cell Activation

(2013) Z. Tan et al.   JOURNAL OF IMMUNOLOGY

Sesame oil mitigates nutritional steatohepatitis via attenuation of oxidative stress and inflammation: a tale of two-hit hypothesis

(2013) Srinivasan Periasamy et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Strain dependence of diet-induced NASH and liver fibrosis in obese mice is linked to diabetes and inflammatory phenotype

(2013) Geoffrey C. Farrell et al.   LIVER INTERNATIONAL

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Inflammation and liver tumorigenesis

(2013) Beicheng Sun et al.   Frontiers of Medicine

Liver carcinogenesis: Rodent models of hepatocarcinoma and cholangiocarcinoma

(2012) Samuele De Minicis et al.   DIGESTIVE AND LIVER DISEASE

IL-17A and IL-25: therapeutic targets for allergic and exacerbated asthmatic disease

(2012) Bryan C Petersen et al.   Future Medicinal Chemistry

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

(2012) Fanli Meng et al.   GASTROENTEROLOGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target

(2012) Hua Wang et al.   International Journal of Biological Sciences

IL-23R polymorphisms, HBV infection, and risk of hepatocellular carcinoma in a high-risk Chinese population

(2012) Yan Xu et al.   JOURNAL OF GASTROENTEROLOGY

Hepatoprotective and anti-inflammatory cytokines in alcoholic liver disease

(2012) Bin Gao   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Mouse intragastric infusion (iG) model

(2012) Akiko Ueno et al.   Nature Protocols

Targeting IL-17 and TH17 cells in chronic inflammation

(2012) Pierre Miossec et al.   NATURE REVIEWS DRUG DISCOVERY

Interleukin 23 Promotes Hepatocellular Carcinoma Metastasis via NF-Kappa B Induced Matrix Metalloproteinase 9 Expression

(2012) Jian Li et al.   PLoS One

Vitamin D deficiency: Correlation to interleukin-17, interleukin-23 and PIIINP in hepatitis C virus genotype 4

(2012) Mona F Schaalan   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular targets in the treatment of alcoholic hepatitis

(2012) Ashwin D Dhanda   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular Mechanisms of Alcoholic Liver Disease: Innate Immunity and Cytokines

(2011) Andrew M. Miller et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease

(2011) Y. Tang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3

(2011) Runqiu Jiang et al.   HEPATOLOGY

Functional Specialization of Interleukin-17 Family Members

(2011) Yoichiro Iwakura et al.   IMMUNITY

Genetic variants in candidate genes influencing NAFLD progression

(2011) Michelino Di Rosa et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma

(2011) Fang-Ming Gu et al.   Molecular Cancer

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

A 52-Week Trial Comparing Briakinumab with Methotrexate in Patients with Psoriasis

(2011) Kristian Reich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin 17A Promotes Hepatocellular Carcinoma Metastasis via NF-kB Induced Matrix Metalloproteinases 2 and 9 Expression

(2011) Jian Li et al.   PLoS One

Th17 cells and their associated cytokines in liver diseases

(2010) Fouad Lafdil et al.   Cellular & Molecular Immunology

Role of IL-17 and Th17 Cells in Liver Diseases

(2010) Linda Hammerich et al.   Clinical & Developmental Immunology

Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: A systematic review

(2010) George V. Papatheodoridis et al.   JOURNAL OF HEPATOLOGY

The role of the gut microbiota in nonalcoholic fatty liver disease

(2010) Ahmed Abu-Shanab et al.   Nature Reviews Gastroenterology & Hepatology

Repopulation Efficiencies of Adult Hepatocytes, Fetal Liver Progenitor Cells, and Embryonic Stem Cell-Derived Hepatic Cells in Albumin-Promoter-Enhancer Urokinase-Type Plasminogen Activator Mice

(2009) Dhivya Haridass et al.   AMERICAN JOURNAL OF PATHOLOGY

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Hepatic Expression of CXC Chemokines Predicts Portal Hypertension and Survival in Patients With Alcoholic Hepatitis

(2009) Marlene Dominguez et al.   GASTROENTEROLOGY

Stem Cells and Liver Regeneration

(2009) Andrew W. Duncan et al.   GASTROENTEROLOGY

Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been

(2009) Timothy F. Osborne et al.   GENES & DEVELOPMENT

Alcoholic liver disease

(2009) Robert S. O'Shea et al.   HEPATOLOGY

Interleukin-17-producing CD4+ T cells increase with severity of liver damage in patients with chronic hepatitis B

(2009) Ji-Yuan Zhang et al.   HEPATOLOGY

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

IL-17A Controls IL-17F Production and Maintains Blood Neutrophil Counts in Mice

(2009) S. von Vietinghoff et al.   JOURNAL OF IMMUNOLOGY

IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells

(2009) C. Diveu et al.   JOURNAL OF IMMUNOLOGY

Alcoholic Hepatitis

(2009) Michael R. Lucey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Structure–function relationships in the IL-17 receptor: Implications for signal transduction and therapy

(2008) Fang Shen et al.   CYTOKINE

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

The interleukin-17 pathway is involved in human alcoholic liver disease

(2008) Arnaud Lemmers et al.   HEPATOLOGY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Interleukin 21: a cytokine/cytokine receptor system that has come of age

(2008) Warren J. Leonard et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

(2007) Rosanne Spolski et al.   Annual Review of Immunology

Alcohol induced hepatic fibrosis: Role of acetaldehyde

(2007) Tommaso Mello et al.   MOLECULAR ASPECTS OF MEDICINE