Article
Biochemistry & Molecular Biology
Mohammed El-Gedamy, Zakaria El-khayat, Hassan Abol-Enein, Afaf El-said, Eslam El-Nahrery
Summary: The genetic variant rs1884444 G/T of IL-23R is significantly associated with a reduced risk of bladder urothelial carcinoma (BUC), with the T allele potentially serving as a reliable genetic marker for good prognosis. The G/T variation may regulate BUC risk through modulation of the IL-23/IL-17 pathway.
Article
Oncology
Yulong Chen, Xunjun Yang, Yao Chen, Guorong Chen, Cheryl A. Winkler, Ping An, Jianxin Lyu
Summary: This study identified for the first time an association between genetic variations in SOAT1 and the occurrence of HCC, indicating a potential role of SOAT1 in the development of HCC that requires further investigation.
Review
Genetics & Heredity
Mohammed El-Gedamy, Zakaria El-khayat, Hassan Abol-Enein, Afaf El-said, Eslam El-Nahrery
Summary: The study examined the impact of the rs10889677A/C SNP in the IL-23R gene on the development and progression of bladder cancer in Egyptians, finding a significant association of the rs10889677C allele with increased risk of BLC. Additionally, elevated serum levels of IL-23R protein in BLC patients were correlated with the rs10889677A/C polymorphism. Meta-analysis across different ethnicities confirmed the SNP's significant correlation with increased risk of bladder cancer in the overall population.
Article
Multidisciplinary Sciences
Daniel Wai-Hung Ho, Yu-Man Tsui, Lo-Kong Chan, Karen Man-Fong Sze, Xin Zhang, Jacinth Wing-Sum Cheu, Yung-Tuen Chiu, Joyce Man-Fong Lee, Albert Chi-Yan Chan, Elaine Tin-Yan Cheung, Derek Tsz-Wai Yau, Nam-Hung Chia, Irene Lai-Oi Lo, Pak-Chung Sham, Tan-To Cheung, Carmen Chak-Lui Wong, Irene Oi-Lin Ng
Summary: The interaction between tumor cells and immune cells in the tumor microenvironment plays a crucial role in tumor immunity, as evidenced by single-cell RNA sequencing analysis in HBV-associated human hepatocellular carcinoma patients. This study reveals the immunosuppressive landscape and intercellular interactions, providing mechanistic insights for the development of effective immune-oncology treatments in hepatocellular carcinoma.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Jusi Wang, Tingyu Chen, Weifeng Tang, Mingqiang Kang, Shuchen Chen
Summary: The study found that the rs2227282 (C > G) and rs2243283 (C > G) loci in the IL4 gene play protective roles in the development of ESCC, reducing the risk for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Qiongguang Huang, Yingchun Liu, Moqin Qiu, Qiuling Lin, Xueyan Wei, Zihan Zhou, Xiumei Liang, Runwei Li, Weiyi Chen, Xianguo Zhou, Hongping Yu
Summary: The study found that the A allele of MAP3K14 rs2074292 may be a potential predictor of HBV-HCC survival, likely regulating MAP3K14 mRNA expression.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanmei Wu, Zibo Lin, Meihua Luo, Xinfa Yu, Sidong Chen, Li Liu
Summary: The study identified associations between certain SNPs of the INTS10 gene and the risk of HBV-related HCC. Patients in the highest tertile of the genetic risk score had an increased risk compared to those in the lowest tertile, and drinking may exacerbate this risk.
MOLECULAR CARCINOGENESIS
(2021)
Article
Toxicology
Qiuling Lin, Moqin Qiu, Xueyan Wei, Zhouyun Xiang, Zihan Zhou, Iiangyan Ji, Xiumei Liang, Xianguo Zhou, Qiuping Wen, Yingchun Liu, Hongping Yu
Summary: In this study, three potentially functional SNPs were identified, which were significantly associated with the overall survival of HBV-related HCC patients. The joint effects of these three SNPs showed a significant association with the poor survival of HCC. The analysis also revealed a lower mRNA expression level of SOS2 and RASGRF2 associated with specific alleles of these SNPs.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yukio Takamori, Takehiro Ando, Masashi Sato, Santhana Vedi, Daisuke Fuji, Takumi Yokoyama, Keita Tsukamoto, Mizuki Yamamoto, Takashi Kawakami
Summary: The RNA aptamer selected against IL-23 through SELEX can bind to IL-23 and inhibit interaction between IL-23 and IL-23R, showing potential for the treatment of inflammatory autoimmune diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Qing Zhu, Yarui Ma, Junbo Liang, Zhewen Wei, Mo Li, Ying Zhang, Mei Liu, Huan He, Chunfeng Qu, Jianqiang Cai, Xiaobing Wang, Yixin Zeng, Yuchen Jiao
Summary: The study found that the aryl hydrocarbon receptor (AHR) plays a crucial role in the toxicity of AFB1-associated HCC, and suggests that anti-PD-L1 therapy may be a therapeutic option for AFB1-related HCC.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Genetics & Heredity
Hongyuan Cui, Weiqi Rong, Jie Ma, Qing Zhu, Boyue Jiang, Lili Zhang, Chang Li, Zhongling Zhuo, Meng Chen
Summary: DNA methylation on N6-adenine (6mA) has been identified as a potential epigenetic marker in prokaryotes and eukaryotes. This study used Nanopore sequencing to globally profile 6mA sites in the genome of hepatocellular carcinoma, revealing widespread distribution throughout the human genome. The 6mA sites were found to be associated with metabolic processes and gene transcription, and may serve as potential biomarkers for cancer diagnosis and treatment.
Article
Chemistry, Multidisciplinary
Ruth Rodriguez-Montano, Alondra del Carmen Ruiz-Gutierrez, Vianeth Maria del Carmen Martinez-Rodriguez, Juan Ramon Gomez-Sandoval, Juan Manuel Guzman-Flores, Julieta Sarai Becerra-Ruiz, Ana Lourdes Zamora-Perez, Celia Guerrero-Velazquez
Summary: This study found that patients with periodontitis have significantly lower levels of IL-17A in plasma, but higher levels of IL-23, IL-17A, and IL-17RA in gingival tissue. Several correlations were also found, suggesting a potential role of the IL-23/IL-17A axis in the progression of periodontitis.
APPLIED SCIENCES-BASEL
(2022)
Article
Oncology
Jia Wang, Yanlin Zhong, Guixia Meng
Summary: The EGF rs4444903 polymorphism does not significantly increase the risk of HBV/HCV, but is associated with increased risk of liver cirrhosis and HCC, particularly among Asians and Caucasians. Larger studies with diverse ethnic populations are needed to confirm these findings.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Grace Lai-Hung Wong, Vicki Wing-Ki Hui, Terry Cheuk-Fung Yip, Lilian Yan Liang, Xinrong Zhang, Yee-Kit Tse, Jimmy Che-To Lai, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong
Summary: Universal HBV vaccination markedly reduces the prevalence of chronic HBV infection and may contribute to the decreased incidences of HCC and hepatic events.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Moqin Qiu, Qiuling Lin, Yingchun Liu, Peiqin Chen, Yunxiang Zhou, Yanji Jiang, Zihan Zhou, Qiuping Wen, Xianguo Zhou, Xiumei Liang, Haijie Gan, Hongping Yu
Summary: This study identified two novel functional SNPs (RPS6KA4 rs600377 T>G and MAP2K5 rs17300363 A>C) in MAPK signaling pathway genes that are associated with the prognosis of HBV-related HCC patients. Functional analysis showed that the RPS6KA4 rs600377 G and MAP2K5 rs17300363 C alleles were associated with elevated mRNA expression levels of the corresponding genes in normal tissues.
MOLECULAR CARCINOGENESIS
(2023)