- Home
- Publications
- Publication Search
- Publication Details
Title
TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis
Authors
Keywords
-
Journal
Science Translational Medicine
Volume 13, Issue 605, Pages eabe0407
Publisher
American Association for the Advancement of Science (AAAS)
Online
2021-08-05
DOI
10.1126/scitranslmed.abe0407
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys
- (2020) Mayur S Mitra et al. TOXICOLOGICAL SCIENCES
- Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape
- (2020) Constance J. Martin et al. Science Translational Medicine
- Specificity, versatility, and control of TGF-β family signaling
- (2019) Rik Derynck et al. Science Signaling
- Comprehensive Integration of Single-Cell Data
- (2019) Tim Stuart et al. CELL
- Epigenetic activation and memory at a TGFB2 enhancer in systemic sclerosis
- (2019) Joseph Yusup Shin et al. Science Translational Medicine
- Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor β2 in a new conformation
- (2019) Laura del Amo-Maestro et al. Scientific Reports
- A mutation update on the LDS-associated genes TGFB2/3 and SMAD2/3
- (2018) Dorien Schepers et al. HUMAN MUTATION
- TGF-β Signaling-Related Genes and Thoracic Aortic Aneurysms and Dissections
- (2018) Norifumi Takeda et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages
- (2017) Xueyang Yu et al. IMMUNITY
- Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice
- (2017) Megan Lo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TGF-β1 Signaling and Tissue Fibrosis
- (2017) Kevin K. Kim et al. Cold Spring Harbor Perspectives in Biology
- The vitronectin RGD motif regulates TGF-β-induced alveolar epithelial cell apoptosis
- (2016) Amanda K. Wheaton et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Structural Biology and Evolution of the TGF-β Family
- (2016) Andrew P. Hinck et al. Cold Spring Harbor Perspectives in Biology
- TGF-β1 and TGF-β2 abundance in liver diseases of mice and men
- (2016) Anne Dropmann et al. Oncotarget
- Cutaneous keratoacanthomas/squamous cell carcinomas associated with neutralization of transforming growth factor β by the monoclonal antibody fresolimumab (GC1008)
- (2015) Mario E. Lacouture et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients
- (2015) Lisa M. Rice et al. JOURNAL OF CLINICAL INVESTIGATION
- Mutations in a TGF-β Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections
- (2015) Aida M. Bertoli-Avella et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- The α v β 1 integrin plays a critical in vivo role in tissue fibrosis
- (2015) Nilgun I. Reed et al. Science Translational Medicine
- Transforming growth factor β—at the centre of systemic sclerosis
- (2014) Robert Lafyatis Nature Reviews Rheumatology
- A Robust High Throughput Platform to Generate Functional Recombinant Monoclonal Antibodies Using Rabbit B Cells from Peripheral Blood
- (2014) Stefan Seeber et al. PLoS One
- Structures of a pan-specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody-antigen interactions
- (2014) Aaron Moulin et al. PROTEIN SCIENCE
- Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis
- (2014) Daryle J DePianto et al. THORAX
- Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease
- (2013) Susan K. Murphy et al. GASTROENTEROLOGY
- Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease
- (2013) Cynthia A. Moylan et al. HEPATOLOGY
- Type 2 alveolar cells are stem cells in adult lung
- (2013) Christina E. Barkauskas et al. JOURNAL OF CLINICAL INVESTIGATION
- Novel combination of collagen dynamics analysis and transcriptional profiling reveals fibrosis-relevant genes and pathways
- (2013) Marjolein E. Blaauboer et al. MATRIX BIOLOGY
- Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
- (2013) Neil C Henderson et al. NATURE MEDICINE
- Excessive Th1 responses due to the absence of TGF- signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis
- (2013) H. Ishigame et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm
- (2012) Mark E Lindsay et al. NATURE GENETICS
- Autocrine/paracrine TGF- 1 inhibits Langerhans cell migration
- (2012) A. Bobr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TGF-β in progression of liver disease
- (2011) Steven Dooley et al. CELL AND TISSUE RESEARCH
- Modeling pulmonary fibrosis with bleomycin
- (2011) Marios A. Mouratis et al. CURRENT OPINION IN PULMONARY MEDICINE
- Latent TGF-β structure and activation
- (2011) Minlong Shi et al. NATURE
- Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
- (2011) J. R. Rock et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors
- (2011) Mark J. Anderton et al. TOXICOLOGIC PATHOLOGY
- Cross Talk among TGF- Signaling Pathways, Integrins, and the Extracellular Matrix
- (2011) J. S. Munger et al. Cold Spring Harbor Perspectives in Biology
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Ternary Complex of Transforming Growth Factor-β1 Reveals Isoform-specific Ligand Recognition and Receptor Recruitment in the Superfamily
- (2010) Sergei Radaev et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding
- (2008) Jay Groppe et al. MOLECULAR CELL
- Newly proposed fibrosis staging criterion for assessing carbon tetrachloride- and albumin complex-induced liver fibrosis in rodents
- (2008) Xin-Yan Zhao et al. PATHOLOGY INTERNATIONAL
- A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions
- (2008) C. Grutter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
- (2007) Antje Moeller et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation