Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction

Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal

(2020) Ksenia Gnedeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiomyocyte cell cycling, maturation, and growth by multinucleation in postnatal swine

(2020) Nivedhitha Velayutham et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo

(2019) Tanner O. Monroe et al.   DEVELOPMENTAL CELL

MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs

(2019) Khatia Gabisonia et al.   NATURE

Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation

(2019) Consuelo Torrini et al.   Cell Reports

Linking YAP to Müller Glia Quiescence Exit in the Degenerative Retina

(2019) Annaïg Hamon et al.   Cell Reports

The Hippo Pathway Blocks Mammalian Retinal Müller Glial Cell Reprogramming

(2019) Elda M. Rueda et al.   Cell Reports

Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis

(2019) Yang Xiao et al.   GENES & DEVELOPMENT

Cardiomyocyte Polyploidy and Implications for Heart Regeneration

(2019) Peiheng Gan et al.   Annual Review of Physiology

Regenerative Potential of Neonatal Porcine Hearts

(2018) Wuqiang Zhu et al.   CIRCULATION

Early Regenerative Capacity in the Porcine Heart

(2018) Lei Ye et al.   CIRCULATION

Rationale and Design of the CONCERT-HF Trial (Combination of Mesenchymal and c-kit+Cardiac Stem Cells As Regenerative Therapy for Heart Failure)Novelty and Significance

(2018) Roberto Bolli et al.   CIRCULATION RESEARCH

Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish

(2018) Juan Manuel González-Rosa et al.   DEVELOPMENTAL CELL

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

(2018) Xing Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiomyocyte Proliferation for Therapeutic Regeneration

(2018) John P. Leach et al.   Current Cardiology Reports

The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration

(2018) Jun Wang et al.   Nature Reviews Cardiology

Unraveling the Complex Story of Immune Responses to AAV Vectors Trial After Trial

(2017) Céline Vandamme et al.   HUMAN GENE THERAPY

Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension

(2017) Mariann Gyöngyösi et al.   Journal of Translational Medicine

Hippo pathway deficiency reverses systolic heart failure after infarction

(2017) John P. Leach et al.   NATURE

Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation

(2017) Yuka Morikawa et al.   NATURE

The extracellular matrix protein agrin promotes heart regeneration in mice

(2017) Elad Bassat et al.   NATURE

Cardiac regeneration strategies: Staying young at heart

(2017) Eldad Tzahor et al.   SCIENCE

Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome

(2016) Margaret E. McCormick et al.   Journal of the American Heart Association

Method for sectioning and sampling hearts for histologic evaluation after delivery of biological agents by transendocardial injection

(2015) Deborah Vela et al.   CARDIOVASCULAR PATHOLOGY

Dynamics of Cell Generation and Turnover in the Human Heart

(2015) Olaf Bergmann et al.   CELL

Functional Recovery of a Human Neonatal Heart After Severe Myocardial InfarctionNovelty and Significance

(2015) Bernhard J. Haubner et al.   CIRCULATION RESEARCH

Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

(2015) Roberto M. Lang et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice

(2015) Yuka Morikawa et al.   Science Signaling

A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice

(2015) Ying Tian et al.   Science Translational Medicine

Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice

(2015) Yuka Morikawa et al.   Science Signaling

Syndromic and non-syndromic disease-linked Cx43 mutations

(2014) Dale W. Laird   FEBS LETTERS

Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice

(2014) S. R. Ali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hypoxia-Inducible MicroRNA Cluster miR-199a∼214 Targets Myocardial PPARδ and Impairs Mitochondrial Fatty Acid Oxidation

(2013) Hamid el Azzouzi et al.   Cell Metabolism

Hippo signaling impedes adult heart regeneration

(2013) T. Heallen et al.   DEVELOPMENT

Small and large animal models in cardiac contraction research: Advantages and disadvantages

(2013) Nima Milani-Nejad et al.   PHARMACOLOGY & THERAPEUTICS

Pre-existing Anti–Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy

(2013) Vedell Louis Jeune et al.   Human Gene Therapy Methods

Challenges measuring cardiomyocyte renewal

(2012) Mark H. Soonpaa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mammalian heart renewal by pre-existing cardiomyocytes

(2012) Samuel E. Senyo et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Diagnostic and prognostic value of 3D NOGA mapping in ischemic heart disease

(2011) Mariann Gyöngyösi et al.   Nature Reviews Cardiology

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL