Toll-like receptor 4–mediated enteric glia loss is critical for the development of necrotizing enterocolitis

The human milk oligosaccharides 2’-fucosyllactose and 6’-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling

(2020) Chhinder P. Sodhi et al.   PEDIATRIC RESEARCH

Dysregulated Mucosal Immunity and Associated Pathogeneses in Preterm Neonates

(2020) Maame Efua S. Sampah et al.   Frontiers in Immunology

Precision-based modeling approaches for necrotizing enterocolitis

(2020) Mark L. Kovler et al.   Disease Models & Mechanisms

Effects of perinatal factors on sirtuin 3, 8-hydroxy-2′- deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an observational study

(2020) Kata Nyárády et al.   International Breastfeeding Journal

Chorioamnionitis induces enteric nervous system injury: effects of timing and inflammation in the ovine fetus

(2020) C. Heymans et al.   MOLECULAR MEDICINE

5-Fluorouracil Induces Enteric Neuron Death and Glial Activation During Intestinal Mucositis via a S100B-RAGE-NFκB-Dependent Pathway

(2019) Deiziane V. S. Costa et al.   Scientific Reports

Prenatal inflammation impairs intestinal microvascular development through a TNF-dependent mechanism and predisposes newborn mice to necrotizing enterocolitis

(2019) Xiaocai Yan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Formula feeding and immature gut microcirculation promote intestinal hypoxia, leading to necrotizing enterocolitis

(2019) Yong Chen et al.   Disease Models & Mechanisms

Hirschsprung-associated enterocolitis in children treated at US children's hospitals

(2019) Liese C.C. Pruitt et al.   JOURNAL OF PEDIATRIC SURGERY

Quinolones Modulate Ghrelin Receptor Signaling: Potential for a Novel Small Molecule Scaffold in the Treatment of Cachexia

(2018) Cristina Torres-Fuentes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fat composition in infant formula contributes to the severity of necrotising enterocolitis

(2018) Chhinder P. Sodhi et al.   BRITISH JOURNAL OF NUTRITION

Enteric Glia Regulate Gastrointestinal Motility but Are Not Required for Maintenance of the Epithelium in Mice

(2017) Meenakshi Rao et al.   GASTROENTEROLOGY

Development of the Neonatal Intestinal Microbiome and Its Association With Necrotizing Enterocolitis

(2016) Timothy G. Elgin et al.   CLINICAL THERAPEUTICS

Necrotizing enterocolitis: new insights into pathogenesis and mechanisms

(2016) Diego F. Niño et al.   Nature Reviews Gastroenterology & Hepatology

Smad7 interrupts TGF-β signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis

(2016) Krishnan MohanKumar et al.   PEDIATRIC RESEARCH

Enteric Neuronal Regulation of Intestinal Inflammation

(2016) Kara Gross Margolis et al.   TRENDS IN NEUROSCIENCES

Enteric glia: A new player in inflammatory bowel diseases

(2015) E Capoccia et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system

(2015) Panagiotis S. Kabouridis et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll-like receptor 4–mediated lymphocyte influx induces neonatal necrotizing enterocolitis

(2015) Charlotte E. Egan et al.   JOURNAL OF CLINICAL INVESTIGATION

Influences of Breast Milk Composition on Gastric Emptying in Preterm Infants

(2015) Sharon L. Perrella et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Causes and Timing of Death in Extremely Premature Infants from 2000 through 2011

(2015) Ravi M. Patel et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Exclusively Human Milk Diet Reduces Necrotizing Enterocolitis

(2014) Kenneth Herrmann et al.   Breastfeeding Medicine

Toll-like Receptor 4-mediated Endoplasmic Reticulum Stress in Intestinal Crypts Induces Necrotizing Enterocolitis

(2014) Amin Afrazi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal Expression and Signaling of TLR4 and TLR9 in the Pathogenesis and Treatment of Necrotizing Enterocolitis

(2014) S. C. Gribar et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor-4 in human and mouse colonic epithelium is developmentally regulated: a possible role in necrotizing enterocolitis

(2014) Di Meng et al.   PEDIATRIC RESEARCH

An Enteroendocrine Cell – Enteric Glia Connection Revealed by 3D Electron Microscopy

(2014) Diego V. Bohórquez et al.   PLoS One

Enteric nervous system abnormalities are present in human necrotizing enterocolitis: potential neurotransplantation therapy

(2014) Yu Zhou et al.   Stem Cell Research & Therapy

A Clinical Perspective of Necrotizing Enterocolitis

(2013) Renu Sharma et al.   CLINICS IN PERINATOLOGY

Enteroglial-derived S100B protein integrates bacteria-induced Toll-like receptor signalling in human enteric glial cells

(2013) Fabio Turco et al.   GUT

Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling

(2013) Ibrahim Yazji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Microbial Products Regulate Murine Gastrointestinal Motility via Toll-Like Receptor 4 Signaling

(2012) Mallappa Anitha et al.   GASTROENTEROLOGY

Intestinal Epithelial Toll-Like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice

(2012) Chhinder P. Sodhi et al.   GASTROENTEROLOGY

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

Essential Roles of Enteric Neuronal Serotonin in Gastrointestinal Motility and the Development/Survival of Enteric Dopaminergic Neurons

(2011) Z. Li et al.   JOURNAL OF NEUROSCIENCE

Heparin-Binding EGF-Like Growth Factor Increases Intestinal Microvascular Blood Flow in Necrotizing Enterocolitis

(2009) Xiaoyi Yu et al.   GASTROENTEROLOGY

Toll-Like Receptor-4 Inhibits Enterocyte Proliferation via Impaired β-Catenin Signaling in Necrotizing Enterocolitis

(2009) Chhinder P. Sodhi et al.   GASTROENTEROLOGY

Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody

(2008) Sebastian Hoff et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Enteric nervous system abnormalities in inflammatory bowel diseases

(2008) v. villanacci et al.   NEUROGASTROENTEROLOGY AND MOTILITY