5-Fluorouracil Induces Enteric Neuron Death and Glial Activation During Intestinal Mucositis via a S100B-RAGE-NFκB-Dependent Pathway

The involvement of mast cells in the irinotecan-induced enteric neurons loss and reactive gliosis

(2017) Ludmila T. Nogueira et al.   Journal of Neuroinflammation

Electrophysiological and morphological changes in colonic myenteric neurons from chemotherapy-treated patients: a pilot study

(2016) S. E. Carbone et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5-fluorouracil

(2016) R. M. McQuade et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis

(2015) Sarah J. MacEachern et al.   GASTROENTEROLOGY

Enteric glia express proteolipid protein 1 and are a transcriptionally unique population of glia in the mammalian nervous system

(2015) Meenakshi Rao et al.   GLIA

S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer’s Disease

(2015) Carla Cirillo et al.   Biomed Research International

Tu1452 Enteroglial-Derived S100B Protein Modulates Differentiation and Proliferation of Human Intestinal Epithelial Cells in a RAGE-Dependent Manner

(2015) Fabio Turco et al.   GASTROENTEROLOGY

The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis

(2015) Deysi V. T. Wong et al.   PLoS One

Treatment with Saccharomyces boulardii reduces the inflammation and dysfunction of the gastrointestinal tract in 5-fluorouracil-induced intestinal mucositis in mice

(2014) Priscilla F. C. Justino et al.   BRITISH JOURNAL OF NUTRITION

Activation of p38-MAPK by CXCL4/CXCR3 axis contributes to p53-dependent intestinal apoptosis initiated by 5-fluorouracil

(2014) Jing Gao et al.   CANCER BIOLOGY & THERAPY

Association of adverse events and survival in colorectal cancer patients treated with adjuvant 5-fluorouracil and leucovorin: Is efficacy an impact of toxicity?

(2014) L.M. Soveri et al.   EUROPEAN JOURNAL OF CANCER

The chemokine CXCL9 exacerbates chemotherapy-induced acute intestinal damage through inhibition of mucosal restitution

(2014) Huili Lu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The dual role of astrocyte activation and reactive gliosis

(2014) Milos Pekny et al.   NEUROSCIENCE LETTERS

Increased Expression of 5-HT3 and NK1 Receptors in 5-Fluorouracil-Induced Mucositis in Mouse Jejunum

(2013) Kenjiro Matsumoto et al.   DIGESTIVE DISEASES AND SCIENCES

Enteroglial-derived S100B protein integrates bacteria-induced Toll-like receptor signalling in human enteric glial cells

(2013) Fabio Turco et al.   GUT

Neurotransmitters involved in fast excitatory neurotransmission directly activate enteric glial cells

(2013) W. Boesmans et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Role of the advanced glycation end products receptor in Crohn’s disease inflammation

(2013) Rachele Ciccocioppo   WORLD JOURNAL OF GASTROENTEROLOGY

Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis

(2012) Orleâncio Gomes R Azevedo et al.   BMC GASTROENTEROLOGY

Inflammatory intestinal damage induced by 5-fluorouracil requires IL-4

(2012) Pedro M.G. Soares et al.   CYTOKINE

The evolution of S100B inhibitors for the treatment of malignant melanoma

(2012) Kira G Hartman et al.   Future Medicinal Chemistry

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

(2012) Brian D Gulbransen et al.   NATURE MEDICINE

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

5-Fluorouracil Induced Intestinal Mucositis via Nuclear Factor-κB Activation by Transcriptomic Analysis and In Vivo Bioluminescence Imaging

(2012) Chung-Ta Chang et al.   PLoS One

Interleukin 1 receptor antagonist reduces lethality and intestinal toxicity of 5-Fluorouracil in a mouse mucositis model

(2011) Zhenqian Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Immunohistochemical analysis of myenteric ganglia and interstitial cells of Cajal in ulcerative colitis

(2011) Nunzia Bernardini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

S100B alters neuronal survival and dendrite extension via RAGE-mediated NF-κB signaling

(2011) Alejandro Villarreal et al.   JOURNAL OF NEUROCHEMISTRY

Proinflammatory stimuli activates human-derived enteroglial cells and induces autocrine nitric oxide production

(2011) C. Cirillo et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The role of enteric glia in gut inflammation

(2011) Georg von Boyen et al.   Neuron Glia Biology

Role of platelet-activating factor in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice

(2010) Pedro M. G. Soares et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Increased mucosal nitric oxide production in ulcerative colitis is mediated in part by the enteroglial-derived S100B protein

(2009) c. cirillo et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Binding of S100 proteins to RAGE: An update

(2008) Estelle Leclerc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Gastrointestinal dysmotility in 5-fluorouracil-induced intestinal mucositis outlasts inflammatory process resolution

(2008) Pedro M. G. Soares et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY