Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models
出版年份 2021 全文链接
标题
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models
作者
关键词
-
出版物
Science Translational Medicine
Volume 13, Issue 599, Pages eaba9772
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2021-06-24
DOI
10.1126/scitranslmed.aba9772
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Tumor mutational burden and PTEN alterations as molecular correlates of response to PD-1/L1 blockade in metastatic triple-negative breast cancer
- (2020) Romualdo Barroso-Sousa et al. CLINICAL CANCER RESEARCH
- Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis
- (2020) Xucheng Hou et al. Nature Nanotechnology
- An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors
- (2020) Katharina Reinhard et al. SCIENCE
- Molecular mechanisms and cellular functions of cGAS–STING signalling
- (2020) Karl-Peter Hopfner et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery
- (2019) Piotr S. Kowalski et al. MOLECULAR THERAPY
- Targeting PI3K in cancer: mechanisms and advances in clinical trials
- (2019) Jing Yang et al. Molecular Cancer
- Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation
- (2019) Nina Germic et al. CELL DEATH AND DIFFERENTIATION
- Cancer nanomedicine for combination cancer immunotherapy
- (2019) Jutaek Nam et al. Nature Reviews Materials
- Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy
- (2019) Yan-ping Xu et al. JOURNAL OF CLINICAL INVESTIGATION
- Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation
- (2019) Lei Miao et al. NATURE BIOTECHNOLOGY
- Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition
- (2019) Na Kong et al. Science Translational Medicine
- Mechanisms of resistance to immune checkpoint inhibitors
- (2018) Russell W Jenkins et al. BRITISH JOURNAL OF CANCER
- Tumour YAP1 and PTEN expression correlates with tumour-associated myeloid suppressor cell expansion and reduced survival in colorectal cancer
- (2018) Rong Yang et al. IMMUNOLOGY
- Combination Immunotherapy of MUC1 mRNA Nano-vaccine and CTLA-4 Blockade Effectively Inhibits Growth of Triple Negative Breast Cancer
- (2018) Lina Liu et al. MOLECULAR THERAPY
- CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy
- (2018) Junchao Cai et al. NATURE CELL BIOLOGY
- Understanding the tumor immune microenvironment (TIME) for effective therapy
- (2018) Mikhail Binnewies et al. NATURE MEDICINE
- Immune-Related Adverse Events Associated with Immune Checkpoint Blockade
- (2018) Michael A. Postow et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cancer immunotherapy using checkpoint blockade
- (2018) Antoni Ribas et al. SCIENCE
- Elimination of established tumors with nanodisc-based combination chemoimmunotherapy
- (2018) Rui Kuai et al. Science Advances
- Biomedical applications of mRNA nanomedicine
- (2018) Qingqing Xiong et al. Nano Research
- Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers
- (2018) Shan Feng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA
- (2018) Mohammad Ariful Islam et al. Nature Biomedical Engineering
- mRNA as novel technology for passive immunotherapy
- (2018) Thomas Schlake et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment
- (2018) Qian Chen et al. Nature Nanotechnology
- Activating PTEN Tumor Suppressor Expression with the CRISPR/dCas9 System
- (2018) Colette Moses et al. Molecular Therapy-Nucleic Acids
- Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma
- (2017) Suzanne George et al. IMMUNITY
- Randomized, Double-Blind, Phase III Trial of Ipilimumab Versus Placebo in Asymptomatic or Minimally Symptomatic Patients With Metastatic Chemotherapy-Naive Castration-Resistant Prostate Cancer
- (2017) Tomasz M. Beer et al. JOURNAL OF CLINICAL ONCOLOGY
- Negative immune checkpoint regulation by VISTA: a mechanism of acquired resistance to anti-PD-1 therapy in metastatic melanoma patients
- (2017) Hojabr Kakavand et al. MODERN PATHOLOGY
- Systemic delivery of factor IX messenger RNA for protein replacement therapy
- (2017) Suvasini Ramaswamy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance
- (2017) Whijae Roh et al. Science Translational Medicine
- Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers
- (2017) H. F. Moffett et al. Nature Communications
- Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses
- (2017) Guangbao Yang et al. Nature Communications
- Engineering CRISPR–Cpf1 crRNAs and mRNAs to maximize genome editing efficiency
- (2017) Bin Li et al. Nature Biomedical Engineering
- Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA
- (2016) Jason B. Miller et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
- (2016) Willy Hugo et al. CELL
- Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment
- (2016) Zhenyu Zhong et al. CELL
- Chemotherapy and immunotherapy: mapping the road ahead
- (2016) Alistair M Cook et al. CURRENT OPINION IN IMMUNOLOGY
- pH-Sensitive Polymeric Nanoparticles Modulate Autophagic Effect via Lysosome Impairment
- (2016) Yao-Xin Lin et al. Small
- Self-Assembled Autophagy-Inducing Polymeric Nanoparticles for Breast Cancer Interference In-Vivo
- (2015) Yi Wang et al. ADVANCED MATERIALS
- Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer
- (2015) Gretchen K. Hubbard et al. CANCER RESEARCH
- Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy
- (2015) Andrew B Sharabi et al. LANCET ONCOLOGY
- Hyperthermic intraperitoneal chemotherapy leads to an anticancer immune response via exposure of cell surface heat shock protein 90
- (2015) B Zunino et al. ONCOGENE
- Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy
- (2015) W. Peng et al. Cancer Discovery
- The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment
- (2015) M. D. Sharma et al. Science Advances
- PTEN: Multiple Functions in Human Malignant Tumors
- (2015) Michele Milella et al. Frontiers in Oncology
- Autophagy: An adaptive metabolic response to stress shaping the antitumor immunity
- (2014) Elodie Viry et al. BIOCHEMICAL PHARMACOLOGY
- Autophagy-dependent ATP release from dying cells via lysosomal exocytosis
- (2013) Yidan Wang et al. Autophagy
- Autophagy and Cellular Immune Responses
- (2013) Yuting Ma et al. IMMUNITY
- Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug
- (2013) X. Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
- (2011) M. Michaud et al. SCIENCE
- Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival
- (2010) T. W. Hand et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Control of autophagy by oncogenes and tumor suppressor genes
- (2008) M C Maiuri et al. CELL DEATH AND DIFFERENTIATION
- The anticancer immune response: indispensable for therapeutic success?
- (2008) Laurence Zitvogel et al. JOURNAL OF CLINICAL INVESTIGATION
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More