Regulation of EGFR activation and signaling by lipids on the plasma membrane

Analysis of transient membrane protein interactions by single-molecule diffusional mobility shift assay

(2021) Min Gyu Jeong et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Identification of lipidomic profiles associated with drug-resistant prostate cancer cells

(2021) Lishann M. Ingram et al.   Lipids in Health and Disease

Lipidomic Signatures for Colorectal Cancer Diagnosis and Progression Using UPLC-QTOF-ESI+MS

(2021) Claudiu Răchieriu et al.   Biomolecules

Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis

(2020) Akriti Kharbanda et al.   Science Signaling

Profiling of subcellular EGFR interactome reveals hnRNP A3 modulates nuclear EGFR localization

(2020) Tong-Hong Wang et al.   Oncogenesis

Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation

(2020) Christian Sieben et al.   PLoS Pathogens

Mapping cisplatin-induced viscosity alterations in cancer cells using molecular rotor and fluorescence lifetime imaging microscopy

(2020) Liubov E. Shimolina et al.   JOURNAL OF BIOMEDICAL OPTICS

Metabolic and lipidomic investigation of the antiproliferative effects of coronatine against human melanoma cells

(2019) Hye-Youn Kim et al.   Scientific Reports

Cholesterol induces epithelial-to-mesenchymal transition of prostate cancer cells by suppressing degradation of EGFR through APMAP

(2019) Siyuan jiang et al.   CANCER RESEARCH

Ganglioside GM1 promotes contact inhibition of growth by regulating the localization of epidermal growth factor receptor from glycosphingolipid‐enriched microdomain to caveolae

(2019) Dinghao Zhuo et al.   CELL PROLIFERATION

Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling

(2019) Junfeng Bi et al.   Cell Metabolism

Distribution, dynamics and functional roles of phosphatidylserine within the cell

(2019) Jason G. Kay et al.   Cell Communication and Signaling

Lipid-Protein Interplay in Dimerization of Juxtamembrane Domains of Epidermal Growth Factor Receptor

(2018) Ryo Maeda et al.   BIOPHYSICAL JOURNAL

Multivalent Cation-Bridged PI(4,5)P 2 Clusters Form at Very Low Concentrations

(2018) Yi Wen et al.   BIOPHYSICAL JOURNAL

Understanding the diversity of membrane lipid composition

(2018) Takeshi Harayama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct visualization of single-molecule membrane protein interactions in living cells

(2018) Do-Hyeon Kim et al.   PLOS BIOLOGY

Emerging functions of the EGFR in cancer

(2017) Sara Sigismund et al.   Molecular Oncology

Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling

(2017) Hye-Youn Kim et al.   Scientific Reports

Alternative packing of EGFR transmembrane domain suggests that protein–lipid interactions underlie signal conduction across membrane

(2016) Eduard V. Bocharov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR

(2016) Mohammed Kaplan et al.   CELL

The role of cholesterol in membrane fusion

(2016) Sung-Tae Yang et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications

(2016) Addys González Palomo et al.   CLINICAL & EXPERIMENTAL METASTASIS

Free Energy Landscape of Lipid Interactions with Regulatory Binding Sites on the Transmembrane Domain of the EGF Receptor

(2016) George Hedger et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Comparative lipidomic study of urothelial cancer models: association with urothelial cancer cell invasiveness

(2016) Yang Yu et al.   Molecular BioSystems

Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling

(2016) Kristin B. Runkle et al.   MOLECULAR CELL

Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol

(2016) Shu-Lin Liu et al.   Nature Chemical Biology

Lipid raft localization of epidermal growth factor receptor alters matrix metalloproteinase-1 expression in SiHa cells via the MAPK/ERK signaling pathway

(2016) Zongfeng Zhang et al.   Oncology Letters

Comparative metabolic and lipidomic profiling of human breast cancer cells with different metastatic potentials

(2016) Hye-Youn Kim et al.   Oncotarget

JAK2 activation by growth hormone and other cytokines

(2015) Michael J. Waters et al.   BIOCHEMICAL JOURNAL

Cholesterol-Induced Lipophobic Interaction between Transmembrane Helices Using Ensemble and Single-Molecule Fluorescence Resonance Energy Transfer

(2015) Yoshiaki Yano et al.   BIOCHEMISTRY

Interactions of the EGFR juxtamembrane domain with PIP 2 -containing lipid bilayers: Insights from multiscale molecular dynamics simulations

(2015) Khairul Bariyyah Abd Halim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Plasma Membrane Organization of Epidermal Growth Factor Receptor in Resting and Ligand-Bound States

(2015) Nirmalya Bag et al.   BIOPHYSICAL JOURNAL

GM3 and cancer

(2015) Sen-Itiroh Hakomori et al.   GLYCOCONJUGATE JOURNAL

Emerging roles of PtdIns(4,5)P2 - beyond the plasma membrane

(2015) X. Tan et al.   JOURNAL OF CELL SCIENCE

N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes

(2015) Karol Kaszuba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake

(2015) Jonathan W. Haskins et al.   Science Signaling

Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR

(2015) Linara Gabitova et al.   Cell Reports

Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake

(2015) Jonathan W. Haskins et al.   Science Signaling

Regulation of EGFR nanocluster formation by ionic protein-lipid interaction

(2014) Ye Wang et al.   CELL RESEARCH

Point Mutations in Dimerization Motifs of the Transmembrane Domain Stabilize Active or Inactive State of the EphA2 Receptor Tyrosine Kinase

(2014) George V. Sharonov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ganglioside GM3 exerts opposite effects on motility via epidermal growth factor receptor and hepatocyte growth factor receptor-mediated migration signaling

(2014) YING LI et al.   Molecular Medicine Reports

Structural and Functional Characterization of Alternative Transmembrane Domain Conformations in VEGF Receptor 2 Activation

(2014) Sandro Manni et al.   STRUCTURE

Membrane Interaction of Bound Ligands Contributes to the Negative Binding Cooperativity of the EGF Receptor

(2014) Anton Arkhipov et al.   PLoS Computational Biology

Lipid Clustering Correlates with Membrane Curvature as Revealed by Molecular Simulations of Complex Lipid Bilayers

(2014) Heidi Koldsø et al.   PLoS Computational Biology

Architecture and Membrane Interactions of the EGF Receptor

(2013) Anton Arkhipov et al.   CELL

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor

(2013) Nicholas F. Endres et al.   CELL

Ganglioside GM3 inhibits hepatoma cell motility via down-regulating activity of EGFR and PI3K/AKT signaling pathway

(2013) Huang X et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Transmembrane helix orientation influences membrane binding of the intracellular juxtamembrane domain in Neu receptor peptides

(2013) C. Matsushita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics

(2013) Sarah Foerster et al.   PROTEOMICS

Structure of FGFR3 Transmembrane Domain Dimer: Implications for Signaling and Human Pathologies

(2013) Eduard V. Bocharov et al.   STRUCTURE

Characterization of the diffusion of epidermal growth factor receptor clusters by single particle tracking

(2012) Mohan Boggara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Detection of N-glycolyated gangliosides in non-small-cell lung cancer using GMR8 monoclonal antibody

(2012) Nobuyoshi Hayashi et al.   CANCER SCIENCE

Lipidomic analysis of phospholipids from human mammary epithelial and breast cancer cell lines

(2012) M. Luísa Dória et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Alteration of EGFR Spatiotemporal Dynamics Suppresses Signal Transduction

(2012) Harmony F. Turk et al.   PLoS One

Cholesterol asymmetry in synaptic plasma membranes

(2011) W. Gibson Wood et al.   JOURNAL OF NEUROCHEMISTRY

Human Epidermal Growth Factor Receptor (EGFR) Aligned on the Plasma Membrane Adopts Key Features of Drosophila EGFR Asymmetry

(2011) C. J. Tynan et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity

(2011) Gregory D. Fairn et al.   NATURE CELL BIOLOGY

Regulation of Epidermal Growth Factor Receptor Through Interaction of Ganglioside GM3 with GlcNAc of N-Linked Glycan of the Receptor: Demonstration in ldlD Cells

(2011) Feng Guan et al.   NEUROCHEMICAL RESEARCH

Regulation of human EGF receptor by lipids

(2011) U. Coskun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Membranes: The Lipid Perspective

(2011) Ünal Coskun et al.   STRUCTURE

The Distribution and Function of Phosphatidylserine in Cellular Membranes

(2010) Peter A. Leventis et al.   Annual Review of Biophysics

Self-Association of Models of Transmembrane Domains of ErbB Receptors in a Lipid Bilayer

(2010) Anupam Prakash et al.   BIOPHYSICAL JOURNAL

Heterophilic NeuGcGM3 ganglioside cancer vaccine in advanced melanoma patients: Results of a phase Ib/IIa study

(2010) Marta Osorio et al.   CANCER BIOLOGY & THERAPY

Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

(2010) Diego Alvarado et al.   CELL

Lipid map of the mammalian cell

(2010) G. van Meer et al.   JOURNAL OF CELL SCIENCE

Epidermal Growth Factor Receptor Activation Remodels the Plasma Membrane Lipid Environment To Induce Nanocluster Formation

(2010) N. Ariotti et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation

(2010) Ioannis E. Michailidis et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Distribution of resting and ligand-bound ErbB1 and ErbB2 receptor tyrosine kinases in living cells using number and brightness analysis

(2010) P. Nagy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmembrane helix-helix interactions involved in ErbB receptor signaling

(2010) Florian Cymer et al.   Cell Adhesion & Migration

Lipid Raft Composition Modulates Sphingomyelinase Activity and Ceramide-Induced Membrane Physical Alterations

(2009) Liana C. Silva et al.   BIOPHYSICAL JOURNAL

Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription (STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer

(2009) Hester van Cruijsen et al.   BMC CANCER

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

(2009) Natalia Jura et al.   CELL

Nanoscale Imaging of Epidermal Growth Factor Receptor Clustering

(2009) Abedelnasser Abulrob et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: Direct interaction of GM3 with VEGFR-2

(2008) T.-W. Chung et al.   GLYCOBIOLOGY

Defining the Importance of Phosphatidylserine Synthase-1 (PSS1)

(2008) Devi Arikketh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells

(2008) R.-H. Tao et al.   JOURNAL OF CELL SCIENCE

Thematic Review Series: Sphingolipids.Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a

(2008) Purna Mukherjee et al.   JOURNAL OF LIPID RESEARCH

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway

(2008) A. R. Todeschini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein-Protein Interactions in the Membrane: Sequence, Structural, and Biological Motifs

(2008) David T. Moore et al.   STRUCTURE

Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains

(2007) Adriane Regina Todeschini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS