JAK2 activation by growth hormone and other cytokines

Lyn kinase plays important roles in erythroid expansion, maturation and erythropoietin receptor signalling by regulating inhibitory signalling pathways that control survival

(2014) Neli S. Slavova-Azmanova et al.   BIOCHEMICAL JOURNAL

The molecular regulation of Janus kinase (JAK) activation

(2014) Jeffrey J. Babon et al.   BIOCHEMICAL JOURNAL

Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms

(2014) Neha Bhagwat et al.   BLOOD

Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease

(2014) S. Spoerl et al.   BLOOD

Who climbs the tryptophan ladder? On the structure and function of the WSXWS motif in cytokine receptors and thrombospondin repeats

(2014) Johan G. Olsen et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Selective JAK inhibitors

(2014) Brian W Dymock et al.   Future Medicinal Chemistry

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase

(2014) Yibing Shan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tofacitinib versus Methotrexate in Rheumatoid Arthritis

(2014) Eun Bong Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

(2014) P. J. Lupardus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor

(2014) A. J. Brooks et al.   SCIENCE

Inhibition of IL-6 family cytokines by SOCS3

(2014) Jeffrey J. Babon et al.   SEMINARS IN IMMUNOLOGY

The role of pacritinib in the management of myelofibrosis

(2014) Vu H Duong et al.   Expert Review of Hematology

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

(2014) Sophie E. Broughton et al.   Cell Reports

Granulocyte Colony-Stimulating Factor Receptor Mutations in Myeloid Malignancy

(2014) Clifford Liongue et al.   Frontiers in Oncology

gp130 activation is regulated by D2–D3 interdomain connectivity

(2013) Antje Schütt et al.   BIOCHEMICAL JOURNAL

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

(2013) Leila N. Varghese et al.   BIOCHEMICAL JOURNAL

Lymphoid malignancies: Another face to the Janus kinases

(2013) Linda M. Scott   BLOOD REVIEWS

Open-label study of oral CEP-701 (lestaurtinib) in patients with polycythaemia vera or essential thrombocythaemia withJAK2-V617F mutation

(2013) Elizabeth Hexner et al.   BRITISH JOURNAL OF HAEMATOLOGY

Signalling by the βc family of cytokines

(2013) Timothy R. Hercus et al.   CYTOKINE & GROWTH FACTOR REVIEWS

CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia

(2013) A Pardanani et al.   LEUKEMIA

Ab Initio Modeling and Experimental Assessment of Janus Kinase 2 (JAK2) Kinase-Pseudokinase Complex Structure

(2013) Xiaobo Wan et al.   PLoS Computational Biology

Regulation of JAK2 Activation by Janus Homology 2: Evidence from Molecular Dynamics Simulations

(2012) Shunzhou Wan et al.   Journal of Chemical Information and Modeling

Heterodimeric JAK–STAT activation as a mechanism of persistence to JAK2 inhibitor therapy

(2012) Priya Koppikar et al.   NATURE

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

(2012) Rajintha M Bandaranayake et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis

(2012) Srdan Verstovsek et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity

(2011) Que T. Lambert et al.   BIOCHEMICAL JOURNAL

Orientation-specific signalling by thrombopoietin receptor dimers

(2011) Judith Staerk et al.   EMBO JOURNAL

Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation

(2011) Erin E. Matthews et al.   FASEB JOURNAL

Growth Hormone Signaling in Human T47D Breast Cancer Cells: Potential Role for a Growth Hormone Receptor-Prolactin Receptor Complex

(2011) Jie Xu et al.   MOLECULAR ENDOCRINOLOGY

Prolactin regulation of the prostate gland: a female player in a male game

(2011) Vincent Goffin et al.   Nature Reviews Urology

Effects of Clinically Relevant MPL Mutations in the Transmembrane Domain Revealed at the Atomic Level through Computational Modeling

(2011) Tai-Sung Lee et al.   PLoS One

Structural Snapshots of Full-Length Jak1, a Transmembrane gp130/IL-6/IL-6Rα Cytokine Receptor Complex, and the Receptor-Jak1 Holocomplex

(2011) Patrick J. Lupardus et al.   STRUCTURE

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common  -subunit

(2010) M. Perugini et al.   BLOOD

F104S c-Mpl responds to a transmembrane domain−binding thrombopoietin receptor agonist: Proof of concept that selected receptor mutations in congenital amegakaryocytic thrombocytopenia can be stimulated with alternative thrombopoietic agents

(2010) Norma E. Fox et al.   EXPERIMENTAL HEMATOLOGY

Crystal Structure of an Affinity-matured Prolactin Complexed to Its Dimerized Receptor Reveals the Topology of Hormone Binding Site 2

(2010) Isabelle Broutin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Entire Ectodomain of gp130

(2010) Yibin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

gp130 at the nexus of inflammation, autoimmunity, and cancer

(2010) J. S. Silver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Structural Characterization of the Stem–Stem Dimerization Interface between Prolactin Receptor Chains Complexed with the Natural Hormone

(2010) Jan van Agthoven et al.   JOURNAL OF MOLECULAR BIOLOGY

The growth hormone receptor: mechanism of activation and clinical implications

(2010) Andrew J. Brooks et al.   Nature Reviews Endocrinology

Construction and genetic selection of small transmembrane proteins that activate the human erythropoietin receptor

(2010) Tobin J. Cammett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of GH signaling and GH-independent stimulation of growth in zebrafish by introduction of a constitutively activated GHR construct

(2010) A. S. Ishtiaq Ahmed et al.   TRANSGENIC RESEARCH

The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity

(2009) J. Ding et al.   BLOOD

The Influence of Domain Structures on the Signal Transduction of Chimeric Receptors Derived from the Erythropoietin Receptor

(2009) Wenhai Liu et al.   JOURNAL OF BIOCHEMISTRY

Turning the growth hormone receptor on: Evidence that hormone binding induces subunit rotation

(2009) David Poger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort

(2008) P. A. Beer et al.   BLOOD

The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

(2008) Guido Hansen et al.   CELL

Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex

(2008) Georgios Skiniotis et al.   MOLECULAR CELL

JAK2, But Not Src Family Kinases, Is Required for STAT, ERK, and Akt Signaling in Response to Growth Hormone in Preadipocytes and Hepatoma Cells

(2008) Hui Jin et al.   MOLECULAR ENDOCRINOLOGY

An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway

(2008) Scott W. Rowlinson et al.   NATURE CELL BIOLOGY