Scalable live-attenuated SARS-CoV-2 vaccine candidate demonstrates preclinical safety and efficacy

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

(2021) Bryan A. Johnson et al.   NATURE

Domains and Functions of Spike Protein in SARS-Cov-2 in the Context of Vaccine Design

(2021) Xuhua Xia   Viruses-Basel

Mechanisms of Attenuation by Genetic Recoding of Viruses

(2021) Daniel Gonçalves-Carneiro et al.   mBio

The polybasic cleavage site in the SARS-CoV-2 spike modulates viral sensitivity to Type I interferon and IFITM2

(2021) Helena Winstone et al.   JOURNAL OF VIROLOGY

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

(2021) Thomas P. Peacock et al.   Nature Microbiology

Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2

(2020) Xi Xu et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

(2020) Chih-Cheng Lai et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

(2020) Sin Fun Sia et al.   NATURE

The search for a COVID-19 animal model

(2020) Seema S. Lakdawala et al.   SCIENCE

Organ-specific manifestations of COVID-19 infection

(2020) Maria Gavriatopoulou et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Mutations in SARS-CoV-2 viral RNA identified in Eastern India: Possible implications for the ongoing outbreak in India and impact on viral structure and host susceptibility

(2020) Arindam Maitra et al.   JOURNAL OF BIOSCIENCES

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

(2020) Masaki Imai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymorphism and Selection Pressure of SARS-CoV-2 Vaccine and Diagnostic Antigens: Implications for Immune Evasion and Serologic Diagnostic Performance

(2020) Eric Dumonteil et al.   Pathogens

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Live-attenuated H1N1 influenza vaccine candidate displays potent efficacy in mice and ferrets

(2019) Charles B. Stauft et al.   PLoS One

Vaccination of pigs with a codon-pair bias de-optimized live attenuated influenza vaccine protects from homologous challenge

(2018) Bryan S. Kaplan et al.   VACCINE

Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure

(2017) Cyril Le Nouën et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus, in ferrets

(2016) Andrew J. Broadbent et al.   VACCINE

Development of Live-Attenuated Arenavirus Vaccines Based on Codon Deoptimization

(2015) Benson Yee Hin Cheng et al.   JOURNAL OF VIROLOGY

Large-scale recoding of an arbovirus genome to rebalance its insect versus mammalian preference

(2015) Sam H. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization

(2014) C. Le Nouen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice

(2013) Chen Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Random Codon Re-encoding Induces Stable Reduction of Replicative Fitness of Chikungunya Virus in Primate and Mosquito Cells

(2013) Antoine Nougairede et al.   PLoS Pathogens

Slow Fitness Recovery in a Codon-Modified Viral Genome

(2012) J.J. Bull et al.   MOLECULAR BIOLOGY AND EVOLUTION

Live attenuated influenza virus vaccines by computer-aided rational design

(2010) Steffen Mueller et al.   NATURE BIOTECHNOLOGY

Virus Attenuation by Genome-Scale Changes in Codon Pair Bias

(2008) J. R. Coleman et al.   SCIENCE