Rational design of ASCT2 inhibitors using an integrated experimental-computational approach

Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport

(2021) Biao Qiu et al.   Science Advances

Elevator-type mechanisms of membrane transport

(2020) Alisa A. Garaeva et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Novel alanine serine cysteine transporter 2 (ASCT2) inhibitors based on sulfonamide and sulfonic acid ester scaffolds

(2019) Elias Ndaru et al.   JOURNAL OF GENERAL PHYSIOLOGY

Effects of α-tubulin acetylation on microtubule structure and stability

(2019) Lisa Eshun-Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Consolidation alters motor sequence-specific distributed representations

(2019) Basile Pinsard et al.   eLife

Principles for Integrative Structural Biology Studies

(2019) Michael P. Rout et al.   CELL

ASCT2: a potential cancer drug target

(2019) Kanu Wahi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2

(2019) Alisa A. Garaeva et al.   Nature Communications

Advances and Challenges in Rational Drug Design for SLCs

(2019) Rachel-Ann A. Garibsingh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

(2019) Xiaodi Yu et al.   eLife

Simultaneous Determination of Protein Structure and Dynamics Using Cryo-Electron Microscopy

(2018) Massimiliano Bonomi et al.   BIOPHYSICAL JOURNAL

Cryo-EM in drug discovery: achievements, limitations and prospects

(2018) Jean-Paul Renaud et al.   NATURE REVIEWS DRUG DISCOVERY

Cryo-EM structure of the human neutral amino acid transporter ASCT2

(2018) Alisa A. Garaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reversible inhibition of the ClpP protease via an N-terminal conformational switch

(2018) Siavash Vahidi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of the human neutral amino acid transporter ASCT2

(2018) Alisa A. Garaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2

(2018) Rachel-Ann A. Garibsingh et al.   Frontiers in Chemistry

Structure and allosteric inhibition of excitatory amino acid transporter 1

(2017) Juan C. Canul-Tec et al.   NATURE

From ATP synthase dimers to C-ring conformational changes: unified model of the mitochondrial permeability transition pore

(2017) Giuseppe Federico Amodeo et al.   Cell Death & Disease

Metainference: A Bayesian inference method for heterogeneous systems

(2016) M. Bonomi et al.   Science Advances

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer

(2015) M van Geldermalsen et al.   ONCOGENE

Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening

(2015) Claire Colas et al.   PLoS Computational Biology

The Resolution Revolution

(2014) W. Kuhlbrandt   SCIENCE

Coupled ion binding and structural transitions along the transport cycle of glutamate transporters

(2014) Grégory Verdon et al.   eLife

Molecular Determinants for Functional Differences between Alanine-Serine-Cysteine Transporter 1 and Other Glutamate Transporter Family Members

(2013) Amanda J. Scopelliti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-dependent processes in the electroneutral amino acid exchanger ASCT2

(2013) Catherine B. Zander et al.   JOURNAL OF GENERAL PHYSIOLOGY

The SLC1 high-affinity glutamate and neutral amino acid transporter family

(2013) Yoshikatsu Kanai et al.   MOLECULAR ASPECTS OF MEDICINE

Transport dynamics in a glutamate transporter homologue

(2013) Nurunisa Akyuz et al.   NATURE

Binding thermodynamics of a glutamate transporter homolog

(2013) Nicolas Reyes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Inactivation by Hg 2+ and methylmercury of the glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: Prediction of the involvement of a CXXC motif by homology modelling

(2010) Francesca Oppedisano et al.   BIOCHEMICAL PHARMACOLOGY

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Substrates and Non-transportable Analogues Induce Structural Rearrangements at the Extracellular Entrance of the Glial Glutamate Transporter GLT-1/EAAT2

(2008) Shaogang Qu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY