High-throughput suppressor screen demonstrates that RcsF monitors outer membrane integrity and not Bam complex function

The assembly of β-barrel outer membrane proteins

(2021) David Tomasek et al.   CURRENT OPINION IN MICROBIOLOGY

Homeostasis of the Gram-negative cell envelope

(2021) Shreya Saha et al.   CURRENT OPINION IN MICROBIOLOGY

Structure of a nascent membrane protein as it folds on the BAM complex

(2020) David Tomasek et al.   NATURE

Structural insight into the formation of lipoprotein-β-barrel complexes

(2020) Raquel Rodríguez-Alonso et al.   Nature Chemical Biology

The gain-of-function allelebamAE470Kbypasses the essential requirement for BamD in β-barrel outer membrane protein assembly

(2020) Elizabeth M. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IgaA negatively regulates the Rcs Phosphorelay via contact with the RcsD Phosphotransfer Protein

(2020) Erin A. Wall et al.   PLoS Genetics

Functions of the BamBCDE Lipoproteins Revealed by Bypass Mutations in BamA

(2020) Elizabeth M. Hart et al.   JOURNAL OF BACTERIOLOGY

Defining the function of OmpA in the Rcs stress response

(2020) Kilian Dekoninck et al.   eLife

Rcs Phosphorelay Responses to Truncated Lipopolysaccharide-Induced Cell Envelope Stress in Yersinia enterocolitica

(2020) Jiao Meng et al.   MOLECULES

Pushing the envelope: LPS modifications and their consequences

(2019) Brent W. Simpson et al.   NATURE REVIEWS MICROBIOLOGY

Improper Coordination of BamA and BamD Results in Bam Complex Jamming by a Lipoprotein Substrate

(2019) Muralidhar Tata et al.   mBio

The Synthetic Phenotype of ΔbamB ΔbamE Double Mutants Results from a Lethal Jamming of the Bam Complex by the Lipoprotein RcsF

(2019) Elizabeth M. Hart et al.   mBio

Bacterial outer membrane proteins assemble via asymmetric interactions with the BamA β-barrel

(2019) Matthew T. Doyle et al.   Nature Communications

A new antibiotic selectively kills Gram-negative pathogens

(2019) Yu Imai et al.   NATURE

A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier

(2019) Elizabeth M. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation of a β-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA

(2019) James Lee et al.   eLife

The Complex Rcs Regulatory Cascade

(2018) Erin Wall et al.   Annual Review of Microbiology

Swarmer cell development of the bacterium Proteus mirabilis requires the conserved ECA biosynthesis gene, rffG

(2018) Kristin Little et al.   JOURNAL OF BACTERIOLOGY

Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion

(2018) James Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Flagellum Biosynthesis in Response to Cell Envelope Stress in Salmonella enterica Serovar Typhimurium

(2018) Imke Spöring et al.   mBio

Distinct domains of Escherichia coli IgaA connect envelope stress sensing and down-regulation of the Rcs phosphorelay across subcellular compartments

(2018) Nahla A. Hussein et al.   PLoS Genetics

The outer membrane is an essential load-bearing element in Gram-negative bacteria

(2018) Enrique R. Rojas et al.   NATURE

Conformational Changes That Coordinate the Activity of BamA and BamD Allowing β-Barrel Assembly

(2017) Anne L. McCabe et al.   JOURNAL OF BACTERIOLOGY

Classifying β-Barrel Assembly Substrates by Manipulating Essential Bam Complex Members

(2016) Tara F. Mahoney et al.   JOURNAL OF BACTERIOLOGY

Structural basis of outer membrane protein insertion by the BAM complex

(2016) Yinghong Gu et al.   NATURE

Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model

(2016) Suguru Okuda et al.   NATURE REVIEWS MICROBIOLOGY

Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins

(2016) Long Han et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Disruption of lipid homeostasis in the Gram-negative cell envelope activates a novel cell death pathway

(2016) Holly A. Sutterlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the  -barrel assembly machinery complex

(2016) J. Bakelar et al.   SCIENCE

Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM

(2016) Matthew G. Iadanza et al.   Nature Communications

Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins

(2016) Long Han et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A lipoprotein/β-barrel complex monitors lipopolysaccharide integrity transducing information across the outer membrane

(2016) Anna Konovalova et al.   eLife

In Vivo Roles of BamA, BamB and BamD in the Biogenesis of BamA, a Core Protein of the β-Barrel Assembly Machine of Escherichia coli

(2015) Rajeev Misra et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of the β-barrel assembly machine by a peptide that binds BamD

(2015) Christine L. Hagan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detecting Envelope Stress by Monitoring β-Barrel Assembly

(2014) Seung-Hyun Cho et al.   CELL

Structural and functional analysis of the β-barrel domain of BamA from Escherichia coli

(2014) Dongchun Ni et al.   FASEB JOURNAL

Effect of Divalent Cation Removal on the Structure of Gram-Negative Bacterial Outer Membrane Models

(2014) Luke A. Clifton et al.   LANGMUIR

Transmembrane domain of surface-exposed outer membrane lipoprotein RcsF is threaded through the lumen of  -barrel proteins

(2014) A. Konovalova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lateral Opening and Exit Pore Formation Are Required for BamA Function

(2014) Nicholas Noinaj et al.   STRUCTURE

Refolding, crystallization and preliminary X-ray crystallographic studies of the β-barrel domain of BamA, a membrane protein essential for outer membrane protein biogenesis

(2014) Dongchun Ni et al.   Acta Crystallographica Section F-Structural Biology Communications

Bam Lipoproteins Assemble BamA in Vitro

(2013) Christine L. Hagan et al.   BIOCHEMISTRY

Predicting Functionally Informative Mutations in Escherichia coli BamA Using Evolutionary Covariance Analysis

(2013) R. S. Dwyer et al.   GENETICS

The Rcs Stress Response and Accessory Envelope Proteins Are Required for De Novo Generation of Cell Shape in Escherichia coli

(2013) D. K. Ranjit et al.   JOURNAL OF BACTERIOLOGY

Mechanistic link between   barrel assembly and the initiation of autotransporter secretion

(2013) O. Pavlova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective Lipoprotein Sorting Induces lolA Expression through the Rcs Stress Response Phosphorelay System

(2012) K. Tao et al.   JOURNAL OF BACTERIOLOGY

Exploring the relationship between lipoprotein mislocalization and activation of the Rcs signal transduction system in Escherichia coli

(2012) Y. Shiba et al.   MICROBIOLOGY-SGM

Activation of the Escherichia coli  -barrel assembly machine (Bam) is required for essential components to interact properly with substrate

(2012) D. P. Ricci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

When Second Best Is Good Enough: Another Probabilistic Look at Saturation Mutagenesis

(2011) Yuval Nov   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Analysis of the Networks Controlling the Antimicrobial-Peptide-Dependent Induction of Klebsiella pneumoniae Virulence Factors

(2011) Enrique Llobet et al.   INFECTION AND IMMUNITY

Substitutions in the BamA  -Barrel Domain Overcome the Conditional Lethal Phenotype of a  bamB  bamE Strain of Escherichia coli

(2011) R. Tellez et al.   JOURNAL OF BACTERIOLOGY

A Disulfide Bridge Network within the Soluble Periplasmic Domain Determines Structure and Function of the Outer Membrane Protein RCSF

(2011) Vladimir V. Rogov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Outer Membrane Protein RcsF, a New Substrate for the Periplasmic Protein-disulfide Isomerase DsbC

(2011) Pauline Leverrier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antimicrobial Peptides Activate the Rcs Regulon through the Outer Membrane Lipoprotein RcsF

(2010) C. Farris et al.   JOURNAL OF BACTERIOLOGY

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

The Rcs Two-Component System Regulates Expression of Lysozyme Inhibitors and Is Induced by Exposure to Lysozyme

(2009) L. Callewaert et al.   JOURNAL OF BACTERIOLOGY

Contact-Dependent Growth Inhibition Causes Reversible Metabolic Downregulation in Escherichia coli

(2009) S. K. Aoki et al.   JOURNAL OF BACTERIOLOGY

The Rcs Phosphorelay Is a Cell Envelope Stress Response Activated by Peptidoglycan Stress and Contributes to Intrinsic Antibiotic Resistance

(2008) M. E. Laubacher et al.   JOURNAL OF BACTERIOLOGY