Paediatric pharmacokinetics: key considerations

Understanding dosing: children are small adults, neonates are immature children

(2013) B. J. Anderson et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Development of intestinal microbiota in infants and its impact on health

(2013) Sebastien Matamoros et al.   TRENDS IN MICROBIOLOGY

Population Pharmacokinetics of Metronidazole Evaluated Using Scavenged Samples from Preterm Infants

(2012) Michael Cohen-Wolkowiez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Physiologically Based Pharmacokinetic (PBPK) Modeling in Children

(2012) J S Barrett et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Ontogeny of oral drug absorption processes in children

(2012) Miriam G Mooij et al.   Expert Opinion on Drug Metabolism & Toxicology

First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development

(2012) Ashley Strougo et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Pediatric Versus Adult Drug Trials for Conditions With High Pediatric Disease Burden

(2012) F. T. Bourgeois et al.   PEDIATRICS

Population Pharmacokinetics of Piperacillin Using Scavenged Samples From Preterm Infants

(2012) Michael Cohen-Wolkowiez et al.   THERAPEUTIC DRUG MONITORING

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

Paediatric drug development: are population models predictive of pharmacokinetics across paediatric populations?

(2011) Massimo Cella et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Innovative study design for paediatric clinical trials

(2011) Paola Baiardi et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Profound changes in drug metabolism enzymes and possible effects on drug therapy in neonates and children

(2011) Saskia N de Wildt   Expert Opinion on Drug Metabolism & Toxicology

Bile salt composition is secondary to bile salt concentration in determining hydrocortisone and progesterone solubility in intestinal mimetic fluids

(2011) Huda Zughaid et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Determination of diclofenac from paediatric urine samples by stir bar sorptive extraction (SBSE)–HPLC–UV technique

(2011) Prashant Laxman Kole et al.   TALANTA

The pharmacokinetics and pharmacodynamics of rifampicin in adults and children in relation to the dosage recommended for children

(2011) P.R. Donald et al.   TUBERCULOSIS

Review of paediatric gastrointestinal physiology data relevant to oral drug delivery

(2011) Jonathan L. Kaye   International Journal of Clinical Pharmacy

Pharmacokinetic research in children: an analysis of registered records of clinical trials

(2011) R. F. Viergever et al.   BMJ Open

Facilitating pharmacokinetic studies in children: a new use of dried blood spots

(2010) P. Patel et al.   ARCHIVES OF DISEASE IN CHILDHOOD

The role of population PK–PD modelling in paediatric clinical research

(2010) Roosmarijn F. W. De Cock et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Specific aspects of gastro-intestinal transit in children for drug delivery design

(2010) Alexandra Bowles et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Systematic Evaluation of the Descriptive and Predictive Performance of Paediatric Morphine Population Models

(2010) Elke H. J. Krekels et al.   PHARMACEUTICAL RESEARCH

Facilitation of Drug Evaluation in Children by Population Methods and Modelling†

(2009) Michel Tod et al.   CLINICAL PHARMACOKINETICS

Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease

(2009) Trevor N Johnson et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Leveraging prior quantitative knowledge in guiding pediatric drug development: a case study

(2009) Pravin R. Jadhav et al.   PHARMACEUTICAL STATISTICS

Using ontogeny information to build predictive models for drug elimination

(2008) J ALCORN et al.   DRUG DISCOVERY TODAY

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

(2008) Andrea N Edginton et al.   Expert Opinion on Drug Metabolism & Toxicology

Pharmacokinetics and Pharmacodynamics in the Critically Ill Child

(2008) Athena F. Zuppa et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Improving Pediatric Dosing Through Pediatric Initiatives: What We Have Learned

(2008) W. Rodriguez et al.   PEDIATRICS

The ontogeny of drug metabolism enzymes and implications for adverse drug events

(2008) Ronald N. Hines   PHARMACOLOGY & THERAPEUTICS

The problems in scaling adult drug doses to children

(2007) T N Johnson   ARCHIVES OF DISEASE IN CHILDHOOD