Deficiency of ROS-Activated TRPM2 Channel Protects Neurons from Cerebral Ischemia-Reperfusion Injury through Upregulating Autophagy

The Discovery of Novel ACA Derivatives as Specific TRPM2 Inhibitors that Reduce Ischemic Injury Both In Vitro and In Vivo

(2021) Han Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mu-Xiang-You-Fang protects PC12 cells against OGD/R-induced autophagy via the AMPK/mTOR signaling pathway

(2020) Hui-xia Ma et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inflammatory mechanism of cerebral ischemia-reperfusion injury with treatment of stepharine in rats

(2020) Tingyu Hao et al.   PHYTOMEDICINE

Role of TFEB in autophagic modulation of ischemia reperfusion injury in mice kidney and protection by urolithin A

(2019) Ying Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Schizandrin Protects against OGD/R-Induced Neuronal Injury by Suppressing Autophagy: Involvement of the AMPK/mTOR Pathway

(2019) Guangyun Wang et al.   MOLECULES

TRPM2: a candidate therapeutic target for treating neurological diseases

(2018) Jillian Corinne Belrose et al.   ACTA PHARMACOLOGICA SINICA

The role of TRPM2 channels in neurons, glial cells and the blood-brain barrier in cerebral ischemia and hypoxia

(2018) Ekaterina Turlova et al.   ACTA PHARMACOLOGICA SINICA

Oxidant sensor cation channel TRPM2 regulates neutrophil extracellular trap formation and protects against pneumoseptic bacterial infection

(2018) Jitendra Kumar Tripathi et al.   FASEB JOURNAL

Propofol inhibited autophagy through Ca2+/CaMKKβ/AMPK/mTOR pathway in OGD/R-induced neuron injury

(2018) Bei Sun et al.   MOLECULAR MEDICINE

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

(2017) Rhianna C. Laker et al.   Nature Communications

Alteration in Intracellular Zn2+ Homeostasis as a Result of TRPM2 Channel Activation Contributes to ROS-Induced Hippocampal Neuronal Death

(2017) Xin Li et al.   Frontiers in Molecular Neuroscience

Detrimental or beneficial: the role of TRPM2 in ischemia/reperfusion injury

(2016) Kai-yu Zhan et al.   ACTA PHARMACOLOGICA SINICA

Mechanistic study of TRPM2-Ca2+-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition

(2016) Qian Wang et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

AMPK and autophagy in glucose/glycogen metabolism

(2015) Joohun Ha et al.   MOLECULAR ASPECTS OF MEDICINE

Autophagy and Liver Ischemia-Reperfusion Injury

(2015) Raffaele Cursio et al.   Biomed Research International

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

(2014) Xiangnan Zhang et al.   Autophagy

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

TRPM2 Channels Protect against Cardiac Ischemia-Reperfusion Injury

(2014) Barbara A. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Receptor Potential Melastatin Subfamily Member 2 Cation Channel Regulates Detrimental Immune Cell Invasion in Ischemic Stroke

(2014) Mathias Gelderblom et al.   STROKE

TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia

(2014) M Ye et al.   Cell Death & Disease

A differential role of macrophage TRPM2 channels in Ca2+ signaling and cell death in early responses to H2O2

(2013) Jie Zou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

Modulation of NMDAR Subunit Expression by TRPM2 Channels Regulates Neuronal Vulnerability to Ischemic Cell Death

(2013) I. Alim et al.   JOURNAL OF NEUROSCIENCE

Redox implications of AMPK-mediated signal transduction beyond energetic clues

(2012) S. Cardaci et al.   JOURNAL OF CELL SCIENCE

TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death

(2012) S. Verma et al.   NEUROSCIENCE LETTERS

Sex Differences in Neuroprotection Provided by Inhibition of TRPM2 Channels following Experimental Stroke

(2011) Jia Jia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ca2+/Calmodulin-Dependent Kinase (CaMK) Signaling via CaMKI and AMP-Activated Protein Kinase Contributes to the Regulation of WIPI-1 at the Onset of Autophagy

(2011) S. G. Pfisterer et al.   MOLECULAR PHARMACOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Preconditioning induces sustained neuroprotection by downregulation of adenosine 5′-monophosphate-activated protein kinase

(2011) V.R. Venna et al.   NEUROSCIENCE

TRPM2: a multifunctional ion channel for calcium signalling

(2010) Adriana Sumoza-Toledo et al.   JOURNAL OF PHYSIOLOGY-LONDON

RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats

(2009) Yong-qiu Zheng et al.   ACTA PHARMACOLOGICA SINICA

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL