Binding of Gemini Bisbenzimidazole Drugs with Human Telomeric G-Quadruplex Dimers: Effect of the Spacer in the Design of Potent Telomerase Inhibitors
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Title
Binding of Gemini Bisbenzimidazole Drugs with Human Telomeric G-Quadruplex Dimers: Effect of the Spacer in the Design of Potent Telomerase Inhibitors
Authors
Keywords
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Journal
PLoS One
Volume 7, Issue 6, Pages e39467
Publisher
Public Library of Science (PLoS)
Online
2012-06-22
DOI
10.1371/journal.pone.0039467
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Note: Only part of the references are listed.- Recent Developments in the Chemistry and Biology of G-Quadruplexes with Reference to the DNA Groove Binders
- (2012) Akash K. Jain et al. CURRENT PHARMACEUTICAL DESIGN
- Dimeric 1,3-Phenylene-bis(piperazinyl benzimidazole)s: Synthesis and Structure–Activity Investigations on their Binding with Human Telomeric G-Quadruplex DNA and Telomerase Inhibition Properties
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- Structure of Long Human Telomeric RNA (TERRA): G-Quadruplexes Formed by Four and Eight UUAGGG Repeats Are Stable Building Blocks
- (2011) Herry Martadinata et al. BIOCHEMISTRY
- Improvement of porphyrins for G-quadruplex DNA targeting
- (2011) Carmen Romera et al. BIOCHIMIE
- Induction of G-quadruplex DNA structure by Zn(II) 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin
- (2011) Amlan J. Bhattacharjee et al. BIOCHIMIE
- Binding properties of human telomeric quadruplex multimers: A new route for drug design
- (2011) Annunziata Cummaro et al. BIOCHIMIE
- Interaction of G-Quadruplexes with Nonintercalating Duplex-DNA Minor Groove Binding Ligands
- (2011) Akash K. Jain et al. BIOCONJUGATE CHEMISTRY
- Tridentate N-Donor Palladium(II) Complexes as Efficient Coordinating Quadruplex DNA Binders
- (2011) Eric Largy et al. CHEMISTRY-A EUROPEAN JOURNAL
- The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions
- (2011) Robert Hänsel et al. NUCLEIC ACIDS RESEARCH
- G4 motifs correlate with promoter-proximal transcriptional pausing in human genes
- (2011) J. Eddy et al. NUCLEIC ACIDS RESEARCH
- Graphene as a Nanocarrier for Tamoxifen Induces Apoptosis in Transformed Cancer Cell Lines of Different Origins
- (2011) Santosh K. Misra et al. Small
- Groove Binding Ligands for the Interaction with Parallel-Strandedps-Duplex DNA and Triplex DNA
- (2010) Akash K. Jain et al. BIOCONJUGATE CHEMISTRY
- Symmetrical Bisbenzimidazoles with Benzenediyl Spacer: The Role of the Shape of the Ligand on the Stabilization and Structural Alterations in Telomeric G-Quadruplex DNA and Telomerase Inhibition
- (2010) Santanu Bhattacharya et al. BIOCONJUGATE CHEMISTRY
- Structural insights into G-quadruplexes: towards new anticancer drugs
- (2010) Danzhou Yang et al. Future Medicinal Chemistry
- Telomere Shortening Sensitizes Cancer Cells to Selected Cytotoxic Agents: In Vitro and In Vivo Studies and Putative Mechanisms
- (2010) Orit Uziel et al. PLoS One
- Duplex Formation at the 5′ End Affects the Quadruplex Conformation of the Human Telomeric Repeat Overhang in Sodium but Not in Potassium
- (2009) Timur I. Gaynutdinov et al. BIOCHEMISTRY
- Synthesis and Evaluation of a Novel Class of G-Quadruplex-Stabilizing Small Molecules Based on the 1,3-Phenylene-Bis(piperazinyl benzimidazole) System
- (2009) Akash K. Jain et al. BIOCHEMISTRY
- BRACO19 analog dimers with improved inhibition of telomerase and hPot 1
- (2009) Yuan-Te Fu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- High fluorescence selectivity and visual detection ofG-quadruplex structures by a novel dinuclear ruthenium complex
- (2009) Liang Xu et al. CHEMICAL COMMUNICATIONS
- Telomeres and Telomerase: From Discovery to Clinical Trials
- (2009) David R. Corey CHEMISTRY & BIOLOGY
- Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures
- (2009) Zhenjiang Zhang et al. NUCLEIC ACIDS RESEARCH
- Evidence of genome-wide G4 DNA-mediated gene expression in human cancer cells
- (2009) Anjali Verma et al. NUCLEIC ACIDS RESEARCH
- The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells
- (2009) Nassima Temime-Smaali et al. PLoS One
- TRAP–LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules
- (2008) Julie Reed et al. ANALYTICAL BIOCHEMISTRY
- A Metal-Mediated Conformational Switch Controls G-Quadruplex Binding Affinity
- (2008) David Monchaud et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Polymorphism of human telomeric quadruplex structures
- (2008) Jixun Dai et al. BIOCHIMIE
- Molecular Dynamics and Principal Components Analysis of Human Telomeric Quadruplex Multimers
- (2008) Shozeb Haider et al. BIOPHYSICAL JOURNAL
- Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand
- (2008) Guorui Li et al. CHEMICAL COMMUNICATIONS
- Medical Implications of Benzimidazole Derivatives as Drugs Designed for Targeting DNA and DNA Associated Processes
- (2008) Santanu Bhattacharya et al. CURRENT MEDICINAL CHEMISTRY
- The Tail of the Telomere
- (2008) Luigi Petraccone et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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