Loop flexibility in human telomeric quadruplex small-molecule complexes

G-Quadruplex Structures and Their Interaction Diversity with Ligands

(2014) Sulin Zhang et al.   ChemMedChem

Telomeric G-Quadruplex Architecture and Interactions with Potential Drugs

(2014) Claudia Sissi et al.   CURRENT PHARMACEUTICAL DESIGN

N-methylmesoporphyrin IX fluorescence as a reporter of strand orientation in guanine quadruplexes

(2014) Navin C. Sabharwal et al.   FEBS Journal

Multiscale Simulations of Human Telomeric G-Quadruplex DNA

(2014) Matúš Rebič et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K+ Solution

(2014) Prashansa Agrawal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Flexibility and structural conservation in a c-KIT G-quadruplex

(2014) Dengguo Wei et al.   NUCLEIC ACIDS RESEARCH

Elevated Levels of G-Quadruplex Formation in Human Stomach and Liver Cancer Tissues

(2014) Giulia Biffi et al.   PLoS One

Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3

(2013) Wan Jun Chung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification and Characterization of New DNA G-Quadruplex Binders Selected by a Combination of Ligand and Structure-Based Virtual Screening Approaches

(2013) Stefano Alcaro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Design and Evaluation of Naphthalene Diimide G-Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells

(2013) Marialuisa Micco et al.   JOURNAL OF MEDICINAL CHEMISTRY

Telomere Maintenance as a Target for Drug Discovery

(2013) Vijay Sekaran et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of a Promoter Sequence in the B-raf Gene Reveals an Intertwined Dimer Quadruplex

(2013) Dengguo Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution Structure of an Intramolecular (3 + 1) Human Telomeric G-Quadruplex Bound to a Telomestatin Derivative

(2013) Wan Jun Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Finding the end: recruitment of telomerase to telomeres

(2013) Jayakrishnan Nandakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Detection of G-quadruplex DNA in mammalian cells

(2013) A. Henderson et al.   NUCLEIC ACIDS RESEARCH

Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale

(2013) Barira Islam et al.   NUCLEIC ACIDS RESEARCH

Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection

(2013) Robert Buscaglia et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplexes from Human Telomeric DNA: How Many Conformations in PEG Containing Solutions?

(2012) Luigi Petraccone et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Beads-on-a-String Structure of Long Telomeric DNAs under Molecular Crowding Conditions

(2012) Haiqing Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optimized End-Stacking Provides Specificity of N-Methyl Mesoporphyrin IX for Human Telomeric G-Quadruplex DNA

(2012) John M. Nicoludis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Basis for Telomeric G-Quadruplex Targeting by Naphthalene Diimide Ligands

(2012) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1

(2012) Carla Bazzicalupi et al.   NUCLEIC ACIDS RESEARCH

G4LDB: a database for discovering and studying G-quadruplex ligands

(2012) Qian Li et al.   NUCLEIC ACIDS RESEARCH

5'-UTR RNA G-quadruplexes: translation regulation and targeting

(2012) A. Bugaut et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation

(2012) D. Wei et al.   NUCLEIC ACIDS RESEARCH

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

(2012) Sebastian Müller et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Surface area accessibility and the preferred topology of telomeric DNA quadruplex–ligand complexes

(2011) Shozeb M. Haider et al.   BIOCHIMIE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Molecular Basis of Structure–Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes

(2011) Nancy H. Campbell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis of Telomeric RNA Quadruplex−Acridine Ligand Recognition

(2011) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Insight into G-DNA Structural Polymorphism and Folding from Sequence and Loop Connectivity through Free Energy Analysis

(2011) Xiaohui Cang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design

(2011) Jixun Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of Human Telomeric DNA in Crowded Solution

(2011) Brahim Heddi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes

(2011) Xiaohui Cang et al.   NUCLEIC ACIDS RESEARCH

c-MYC promoter G-quadruplex formed at the 5′-end of NHE III 1 element: insights into biological relevance and parallel-stranded G-quadruplex stability

(2011) Raveendra I. Mathad et al.   NUCLEIC ACIDS RESEARCH

Structural and Conformational Requisites in DNA Quadruplex Groove Binding: Another Piece to the Puzzle

(2010) Sandro Cosconati et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex

(2010) Gavin W. Collie et al.   NUCLEIC ACIDS RESEARCH

Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter

(2010) Vitaly Kuryavyi et al.   NUCLEIC ACIDS RESEARCH

The Importance of Negative Superhelicity in Inducing the Formation of G-Quadruplex and i-Motif Structures in the c-Myc Promoter: Implications for Drug Targeting and Control of Gene Expression

(2009) Daekyu Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

A G-Rich Sequence within thec-kitOncogene Promoter Forms a Parallel G-Quadruplex Having Asymmetric G-Tetrad Dynamics

(2009) Shang-Te Danny Hsu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tandem Application of Virtual Screening and NMR Experiments in the Discovery of Brand New DNA Quadruplex Groove Binders

(2009) Sandro Cosconati et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the Human Telomere in K+Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers

(2009) Kah Wai Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Predictable suppression of gene expression by 5′-UTR-based RNA quadruplexes

(2009) Kangkan Halder et al.   NUCLEIC ACIDS RESEARCH

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

(2009) Angela Rizzo et al.   NUCLEIC ACIDS RESEARCH

Arrangements of human telomere DNA quadruplex in physiologically relevant K + solutions

(2009) D. Renčiuk et al.   NUCLEIC ACIDS RESEARCH

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands

(2008) Francisco Cuenca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Topology Conservation and Loop Flexibility in Quadruplex–Drug Recognition: Crystal Structures of Inter- and Intramolecular Telomeric DNA Quadruplex–Drug Complexes

(2008) Gary N. Parkinson et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis of DNA Quadruplex Recognition by an Acridine Drug

(2008) Nancy H. Campbell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres

(2008) Raphaël Rodriguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes

(2008) Johanna Eddy et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes: the beginning and end of UTRs

(2008) Julian Leon Huppert et al.   NUCLEIC ACIDS RESEARCH

Targeting telomeres and telomerase

(2007) Anne De Cian et al.   BIOCHIMIE

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY