Crocetin exerts hypocholesterolemic effect by inducing LDLR and inhibiting PCSK9 and Sortilin in HepG2 cells

Nutritional and health beneficial properties of saffron (Crocus sativus L): a comprehensive review

(2020) Tareq Abu-Izneid et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The Global Burden of Cardiovascular Diseases and Risks

(2020) Gregory A. Roth et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Crocetin and crocin from saffron in cancer chemotherapy and chemoprevention

(2019) Claudio Festuccia et al.   Anti-Cancer Agents in Medicinal Chemistry

Recent advances in novel therapies for lipid disorders

(2019) Annakaisa Tirronen et al.   HUMAN MOLECULAR GENETICS

A comprehensive review on biological activities and toxicology of crocetin

(2019) Maryam Hashemi et al.   FOOD AND CHEMICAL TOXICOLOGY

The fucoidan A3 from the seaweed Ascophyllum nodosum enhances RCT-related genes expression in hyperlipidemic C57BL/6J mice

(2019) Zixun Yang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Crocus sativus L. aqueous extract reduces atherogenesis, increases atherosclerotic plaque stability and improves glucose control in diabetic atherosclerotic animals

(2018) Ei. Christodoulou et al.   ATHEROSCLEROSIS

Vaccines Targeting PCSK9: A Promising Alternative to Passive Immunization with Monoclonal Antibodies in the Management of Hyperlipidaemia?

(2018) Stefan Weisshaar et al.   DRUGS

Naringin Activates AMPK Resulting in Altered Expression of SREBPs, PCSK9, and LDLR To Reduce Body Weight in Obese C57BL/6J Mice

(2018) Guo-Guang Sui et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Triciribine increases LDLR expression and LDL uptake through stabilization of LDLR mRNA

(2018) Katrine Bjune et al.   Scientific Reports

Saffron; An updated review on biological properties with special focus on cardiovascular effects

(2018) Samad Ghaffari et al.   BIOMEDICINE & PHARMACOTHERAPY

Familial Hypercholesterolemia: The Most Frequent Cholesterol Metabolism Disorder Caused Disease

(2018) Asier Benito-Vicente et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Saffron and its derivatives, crocin, crocetin and safranal: a patent review

(2017) Maryam Rameshrad et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Recent advances in the development of novel protein scaffolds based therapeutics

(2017) Asim Azhar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

HDL Cholesterol Metabolism and the Risk of CHD: New Insights from Human Genetics

(2017) Cecilia Vitali et al.   Current Cardiology Reports

Crocetin Inhibits Lipopolysaccharide-Induced Inflammatory Response in Human Umbilical Vein Endothelial Cells

(2016) Lei Song et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors: Present perspectives and future horizons

(2016) K. Yadav et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Impact of Ezetimibe Alone or in Addition to a Statin on Plasma PCSK9 Concentrations in Patients with Type 2 Diabetes and Hypercholesterolemia: A Pilot Study

(2015) Toru Miyoshi et al.   American Journal of Cardiovascular Drugs

Are PCSK9 Inhibitors the Next Breakthrough in the Cardiovascular Field?

(2015) Robert P. Giugliano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Sorting an LDL receptor with bound PCSK9 to intracellular degradation

(2014) Trond P. Leren   ATHEROSCLEROSIS

The Hypercholesterolemia-Risk Gene SORT1 Facilitates PCSK9 Secretion

(2014) Camilla Gustafsen et al.   Cell Metabolism

De novo lipogenesis in health and disease

(2014) Fatima Ameer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Curcumin enhances cell-surface LDLR level and promotes LDL uptake through downregulation of PCSK9 gene expression in HepG2 cells

(2014) Mi-Hsueh Tai et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models

(2014) Claudio Festuccia et al.   Biomed Research International

Quercetin-3-glucoside increases low-density lipoprotein receptor (LDLR) expression, attenuates proprotein convertase subtilisin/kexin 9 (PCSK9) secretion, and stimulates LDL uptake by Huh7 human hepatocytes in culture

(2014) Majambu Mbikay et al.   FEBS Open Bio

Modulation of Lipogenesis and Glucose Consumption in HepG2 Cells and C2C12 Myotubes by Sophoricoside

(2013) Chongming Wu et al.   MOLECULES

Lipid Droplets and Cellular Lipid Metabolism

(2012) Tobias C. Walther et al.   Annual Review of Biochemistry

Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism

(2012) Alanna Strong et al.   JOURNAL OF CLINICAL INVESTIGATION

The PCSK9 decade

(2012) Gilles Lambert et al.   JOURNAL OF LIPID RESEARCH

Neuroprotective efficacy of Nardostachys jatamansi and crocetin in conjunction with selenium in cognitive impairment

(2011) M. Badruzzaman Khan et al.   NEUROLOGICAL SCIENCES

A New Wave of Cellular Imaging

(2010) Derek Toomre et al.   Annual Review of Cell and Developmental Biology

Sterol metabolism and SREBP activation

(2010) Ryuichiro Sato   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The LDL Receptor

(2009) Joseph L. Goldstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibitory effects of crocetin on high glucose-induced apoptosis in cultured human umbilical vein endothelial cells and its mechanism

(2008) Lingdong Meng et al.   ARCHIVES OF PHARMACAL RESEARCH

Molecular basis for LDL receptor recognition by PCSK9

(2008) H. J. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PCSK9 and LDL cholesterol: unravelling the target to design the bullet

(2008) Philippe Costet et al.   TRENDS IN BIOCHEMICAL SCIENCES