Article
Biochemistry & Molecular Biology
Ekaterina Rudnitskaya, Tatiana Kozlova, Alena Burnyasheva, Daniil Peunov, Michail Tyumentsev, Natalia Stefanova, Nataliya Kolosova
Summary: This study investigated the possible influence of early-life vascular dysfunction on Alzheimer's disease (AD) development using OXYS rats as a model. The expression of blood-brain barrier (BBB)-associated genes was found to be altered in the hippocampus and frontal cortex of OXYS rats during the first and second weeks of life. Delayed vascularization and pericyte coating of blood vessels were also observed in OXYS rats. These features may have long-term consequences and contribute to the neurovascular dysfunction observed in OXYS rats late in life, thereby promoting the early development of AD signs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nadezda V. Andrianova, Ljubava D. Zorova, Irina B. Pevzner, Nataliya G. Kolosova, Egor Y. Plotnikov, Dmitry B. Zorov
Summary: Kidney diseases are common among elderly people due to age-related changes in renal tissue. The lack of targeted pharmacotherapies for acute kidney injury (AKI) results in high mortality rates. This study investigated the protective effects of calorie restriction (CR) on ischemic AKI in OXYS rats and found that CR provided significant nephroprotection. Improvements in mitochondrial functioning may be one of the mechanisms for the beneficial effects of CR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Natalia A. Muraleva, Nataliya G. Kolosova, Natalia A. Stefanova
Summary: SkQ1 alleviates AD pathology by suppressing MEK1/2-ERK1/2 signaling pathway activity in the OXYS rat hippocampus, making it a promising candidate drug for human AD treatment.
Article
Biochemistry & Molecular Biology
Natalia S. A. Stefanova, Nataliya G. G. Kolosova
Summary: Previous studies suggest that functional traits of the adult brain can affect susceptibility to Alzheimer's disease. This study analyzed transcriptomes of the prefrontal cortex and hippocampus in senescence-accelerated OXYS rats and control rats during brain maturation. Over 1000 differentially expressed genes were found, indicating reduced efficiency of neuronal contact formation, possibly due to deficits in mitochondrial functions. Three genes showed overexpression in both brain regions of OXYS rats throughout their lifespan, suggesting a contribution to the development of AD-like pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Olga Snytnikova, Yuri Tsentalovich, Renad Sagdeev, Nataliya Kolosova, Oyuna Kozhevnikova
Summary: This study investigated the effects of autophagy modulation on serum metabolites. The results showed that fasting for 48 hours and CQ treatment significantly altered the serum metabolome, primarily affecting fatty acid metabolism and metabolism of several amino acids. The metabolic responses to autophagy modulation were different in OXYS rats and Wistar rats, and altered metabolites in OXYS rats may serve as potential biomarkers of accelerated aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Nataliya G. G. Kolosova, Oyuna S. S. Kozhevnikova, Natalia A. A. Muraleva, Ekaterina A. A. Rudnitskaya, Yuliya V. V. Rumyantseva, Natalia A. A. Stefanova, Darya V. V. Telegina, Mikhail A. A. Tyumentsev, Anzhella Zh. Fursova
Summary: According to the concept suggested by Skulachev et al., aging can be considered as a special form of programmed death, and the mitochondrial antioxidant SkQ1 can inhibit both acute and chronic aging. Studies have confirmed the ability of SkQ1 to inhibit physiological aging, especially in genetically determined accelerated senescence in OXYS rats.
BIOCHEMISTRY-MOSCOW
(2022)
Review
Pharmacology & Pharmacy
Jia Ke, Qinfang Tian, Qixia Xu, Zhenqin Fu, Qiang Fu
Summary: Alzheimer's disease is an irreversible neurodegenerative disorder characterized by a progressive decline in cognitive function, with mitochondrial dysfunction playing a critical role in its development. While therapeutic strategies targeting mitochondrial dysfunction have shown promise in preclinical studies, clinical trials have made little progress thus far.
DRUG DISCOVERY TODAY
(2021)
Review
Biochemistry & Molecular Biology
Javier Donate-Correa, Beatriz Martin-Carro, Jorge B. Cannata-Andia, Carmen Mora-Fernandez, Juan F. Navarro-Gonzalez
Summary: Reducing oxidative stress is crucial in preventing cellular senescence and aging. In kidney disease, targeting oxidative stress, mitochondrial dysfunction, and cellular senescence in kidney cells could be significant for controlling disease progression. This review focuses on the mechanisms linking oxidative stress damage and mitochondrial dysfunction in kidney disease, with a special emphasis on the role of the anti-aging Klotho protein and its modulation of signaling pathways involving known antioxidant systems and mitochondrial function regulators. Klotho is proposed as a promising therapeutic target in combating oxidative stress, mitochondria abnormalities, and cellular senescence in kidney disease patients.
Article
Biochemistry & Molecular Biology
Tatiana Kozlova, Ekaterina Rudnitskaya, Alena Burnyasheva, Natalia Stefanova, Daniil Peunov, Nataliya Kolosova
Summary: Postnatal brain development is highly plastic and can be influenced by maternal care. Poor maternal care can lead to delayed physical and behavioral development in pups, which may contribute to neurodegeneration and Alzheimer's disease-like pathology later in life.
Article
Biochemistry & Molecular Biology
Da-Ye Lee, Kang-Min Lee, Jee-Hyun Um, Young-Yeon Kim, Dong-Hyun Kim, Jeanho Yun, Anna-Maria Psarra
Summary: This study reveals that palmatine efficiently induces mitophagy and stimulates mitochondrial biogenesis. It also shows that palmatine treatment can alleviate mitochondrial dysfunction and improve cognitive function in an Alzheimer's disease mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Md Riad Chowdhury, Hee Kyung Jin, Jae-sung Bae
Summary: This review discusses the role of ceramide, a bioactive sphingolipid metabolite, in the progression and pathogenesis of Alzheimer's disease, and describes the ceramide synthesis pathway and its involvement in the dysregulation of homeostasis.
Review
Medicine, Research & Experimental
Eman E. Alshial, Muhammad Idris Abdulghaney, Al-Hassan Soliman Wadan, Mohamed Abdelfatah Abdellatif, Nada E. Ramadan, Aya Muhammed Suleiman, Nahla Waheed, Maha Abdellatif, Haitham S. Mohammed
Summary: Mitochondria play a crucial role in the nervous system, but dysfunction can contribute to the development of various neurological disorders. This article reviews the functions of mitochondria in the nervous system, explores mechanisms related to dysfunction, and discusses its role in disorders such as Parkinson's disease, multiple sclerosis, Alzheimer's disease, depression, and epilepsy. It also provides an overview of current treatment strategies targeting mitochondrial dysfunction and highlights future directions.
Review
Biochemistry & Molecular Biology
German Plascencia-Villa, George Perry
Summary: The deterioration of brain cells in neurodegenerative diseases is accompanied by mitochondrial dysfunction. Current therapies for Alzheimer's and Parkinson's disease mainly focus on maintaining neurotransmitters and managing symptoms, with limited effectiveness in stopping or reversing the disease. This article discusses alternative molecular targets for treating neurodegeneration, such as regulating calcium ion transport, protein modification, glucose metabolism, antioxidants, metal chelators, vitamin supplementation, and mitochondrial transference. Some of these targeted therapies have shown promise in preclinical and animal studies, and are expected to have positive outcomes in clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Zhen Yang, Xinyuan Shi, Jiale Ren, Hongqing Yin, Dongna Li, Lili Song, Yanjun Zhang
Summary: ZSWF improves cognitive ability and reduces pathological damage and neuronal apoptosis in Alzheimer's disease by regulating neuronal mitochondrial homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Biochemistry & Molecular Biology
Somya Patro, Sujay Ratna, Hianny A. Yamamoto, Andrew T. Ebenezer, Dillon S. Ferguson, Amanpreet Kaur, Brendan C. McIntyre, Ryan Snow, Maria E. Solesio
Summary: Alzheimer's Disease is the most common neurodegenerative disorder in society, with increasing incidence expected as the population ages. Mitochondrial dysfunction has been widely described in the brains of AD patients, and may act as a trigger for early events in the disease. Modulating ATP synthase pharmacologically could be a potential strategy to prevent mitochondrial dysfunction in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Dina Malkeyeva, Elena Kiseleva, Svetlana A. Fedorova
Summary: The study on the effect of Hsp67Bc gene deletion in Drosophila melanogaster revealed that the absence of this gene leads to an increase in autolysosome size, shedding light on the mechanism of macroautophagy.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Ekaterina A. Rudnitskaya, Alena O. Burnyasheva, Tatiana A. Kozlova, Daniil A. Peunov, Nataliya G. Kolosova, Natalia A. Stefanova
Summary: Astrocytes and microglia are more vulnerable to neurodegenerative damage in Alzheimer's disease, especially in the CA3 area. Prolonged supplementation with a mitochondria-targeted antioxidant, SkQ1, can reduce inflammation in glial cells and may be a promising approach for preventing and treating Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dmitry Oshchepkov, Irina Chadaeva, Rimma Kozhemyakina, Karina Zolotareva, Bato Khandaev, Ekaterina Sharypova, Petr Ponomarenko, Anton Bogomolov, Natalya Klimova, Svetlana Shikhevich, Olga Redina, Nataliya G. Kolosova, Maria Nazarenko, Nikolay A. Kolchanov, Arcady Markel, Mikhail Ponomarenko
Summary: In this study, the researchers focused on differentially expressed genes (DEGs) in hypertensive patients and compared them with DEGs related to stress reactivity in rats. They found significant correlations between stress reactivity-related and hypertension-related gene expression changes and identified potential molecular markers for hypertension treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Darya Telegina, Anna K. Antonenko, Anzhela Zh Fursova, Nataliya G. Kolosova
Summary: Glutamate and GABA, the most abundant amino acids in the retina, are involved in the pathogenesis of neurodegenerative disorders. This study analyzed the expression changes of enzymes, transporters, and receptors related to glutamate and GABA synthesis in the aging retina of Wistar rats and senescence-accelerated OXYS rats with AMD-like retinopathy. The results showed age-dependent expression changes of GABAergic-system proteins in both rat strains. Late-stage AMD-like retinopathy in OXYS rats was associated with the upregulation of glutaminase and downregulation of glutamine synthetase, indicating an increase in glutamate levels. Supplementation with melatonin and SkQ1 suppressed the progression of AMD-like pathology in OXYS rats but worsened the condition of the Wistar rat's retina during normal aging.
Article
Biochemistry & Molecular Biology
Oyuna S. Kozhevnikova, Anzhella Zh Fursova, Anna S. Derbeneva, Ida F. Nikulich, Mikhail S. Tarasov, Vasiliy A. Devyatkin, Yulia Rumyantseva, Darya Telegina, Nataliya G. Kolosova
Summary: The study evaluated the association between polymorphisms in genes related to the complement system and neovascular age-related macular degeneration (nAMD) and its treatment response biomarkers. The results showed that certain gene polymorphisms were associated with the risk of nAMD and treatment response.
Article
Biochemistry & Molecular Biology
Natalia S. A. Stefanova, Nataliya G. G. Kolosova
Summary: Previous studies suggest that functional traits of the adult brain can affect susceptibility to Alzheimer's disease. This study analyzed transcriptomes of the prefrontal cortex and hippocampus in senescence-accelerated OXYS rats and control rats during brain maturation. Over 1000 differentially expressed genes were found, indicating reduced efficiency of neuronal contact formation, possibly due to deficits in mitochondrial functions. Three genes showed overexpression in both brain regions of OXYS rats throughout their lifespan, suggesting a contribution to the development of AD-like pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nadezda V. Andrianova, Ljubava D. Zorova, Irina B. Pevzner, Nataliya G. Kolosova, Egor Y. Plotnikov, Dmitry B. Zorov
Summary: Kidney diseases are common among elderly people due to age-related changes in renal tissue. The lack of targeted pharmacotherapies for acute kidney injury (AKI) results in high mortality rates. This study investigated the protective effects of calorie restriction (CR) on ischemic AKI in OXYS rats and found that CR provided significant nephroprotection. Improvements in mitochondrial functioning may be one of the mechanisms for the beneficial effects of CR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Snezhanna Saydakova, Ksenia Morozova, Olga Snytnikova, Maryana Morozova, Lidiya Boldyreva, Elena Kiseleva, Yuri Tsentalovich, Elena Kozhevnikova
Summary: Dietary composition has a significant impact on human health and can influence the development of complex diseases such as obesity, inflammation, and cancer. This study investigated the effects of major dietary phospholipids (PLs) on the morphology of intestinal epithelial cells in mice subjected to high-dose feeding. The results showed that high levels of PLs caused mitochondrial damage and lipid droplet accumulation, making the mitochondria more vulnerable to respiratory uncoupling. However, these mitochondrial changes did not induce intestinal permeability. It is suggested that caution should be exercised when using PL supplementation in individuals with mitochondrial disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anna A. Zhdankina, Dmitry I. Tikhonov, Sergey V. Logvinov, Mark B. Plotnikov, Andrei I. Khlebnikov, Nataliya G. Kolosova
Summary: Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment worldwide. JNK inhibitor IQ-1S shows potential in preventing and treating AMD, as it improves histological abnormalities associated with retinopathy in the OXYS rat model, including improved blood circulation, increased functional activity of the retinal pigment epithelium, reduced VEGF expression, and increased PEDF expression.
Article
Biochemistry & Molecular Biology
Tatiana Kozlova, Ekaterina Rudnitskaya, Alena Burnyasheva, Natalia Stefanova, Daniil Peunov, Nataliya Kolosova
Summary: Postnatal brain development is highly plastic and can be influenced by maternal care. Poor maternal care can lead to delayed physical and behavioral development in pups, which may contribute to neurodegeneration and Alzheimer's disease-like pathology later in life.
Article
Biochemistry & Molecular Biology
Natalia A. Muraleva, Nataliya G. Kolosova
Summary: Age-related macular degeneration (AMD) is a major cause of irreversible visual impairment. Dysregulation of the p38 MAPK signaling pathway (SP) is linked to aging and neurodegenerative diseases. This study found that the activity of the p38 MAPK SP increased with age in healthy rats, and that AMD-like retinopathy in OXYS rats was accompanied by hyperphosphorylation of p38 MAPK and MK2. The progression of retinopathy also coincided with enhanced p38 MAPK-dependent phosphorylation of CryaB in the retina.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Oyuna S. Kozhevnikova, Anzhella Zh. Fursova, Anna S. Derbeneva, Ida F. Nikulich, Vasiliy A. Devyatkin, Nataliya G. Kolosova
Summary: This study aimed to evaluate the association between polymorphic markers of MTOR, SQSTM1, ULK1, MAP1LC3A, and ATG5 genes and the development of nAMD and the response to anti-VEGF therapy. The study found that MTOR gene polymorphisms are associated with the risk of nAMD, and SQSTM1-rs10277 and ULK1-rs3088051 may influence the short-term response to anti-VEGF treatment.
Article
Biochemistry & Molecular Biology
Ekaterina Rudnitskaya, Tatiana Kozlova, Alena Burnyasheva, Daniil Peunov, Michail Tyumentsev, Natalia Stefanova, Nataliya Kolosova
Summary: This study investigated the possible influence of early-life vascular dysfunction on Alzheimer's disease (AD) development using OXYS rats as a model. The expression of blood-brain barrier (BBB)-associated genes was found to be altered in the hippocampus and frontal cortex of OXYS rats during the first and second weeks of life. Delayed vascularization and pericyte coating of blood vessels were also observed in OXYS rats. These features may have long-term consequences and contribute to the neurovascular dysfunction observed in OXYS rats late in life, thereby promoting the early development of AD signs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
D. Malkeyeva, S. A. Fedorova, E. Kiseleva
Summary: Through studying the effects of Hsp67Bc gene deletion on fruit flies, it was found that fruit flies lacking this gene have an extended lifespan under normal and elevated temperature conditions, but reduced fecundity and thermal stress tolerance.
VAVILOVSKII ZHURNAL GENETIKI I SELEKTSII
(2022)