IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice

STING controls nociception via type I interferon signalling in sensory neurons

(2021) Christopher R. Donnelly et al.   NATURE

Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury

(2021) Jesse K. Niehaus et al.   NEURON

The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females

(2020) Yanxia Chen et al.   Science Translational Medicine

Anti–PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates

(2020) Zilong Wang et al.   Science Translational Medicine

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

(2020) Xiaobing Yu et al.   Nature Communications

PD-1 blockade inhibits osteoclast formation and murine bone cancer pain

(2020) Kaiyuan Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Qualitative sex differences in pain processing: emerging evidence of a biased literature

(2020) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Getting in Touch with Mechanical Pain Mechanisms

(2020) Rose Z. Hill et al.   TRENDS IN NEUROSCIENCES

Local Sympathectomy Promotes Anti-inflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice

(2020) Raquel Tonello et al.   ANESTHESIOLOGY

Sex differences in nociceptor translatomes contribute to divergent prostaglandin signaling in male and female mice

(2020) Diana Tavares-Ferreira et al.   BIOLOGICAL PSYCHIATRY

Satellite glial cells promote regenerative growth in sensory neurons

(2020) Oshri Avraham et al.   Nature Communications

PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia

(2020) Changyu Jiang et al.   iScience

Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition

(2020) Zilong Wang et al.   BRAIN

IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes

(2019) Rui Sun et al.   GUT

Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models

(2019) Amanda Avona et al.   JOURNAL OF NEUROSCIENCE

Is Optogenetic Activation of Vglut1-Positive Aβ Low-Threshold Mechanoreceptors Sufficient to Induce Tactile Allodynia in Mice after Nerve Injury?

(2019) Alexander Chamessian et al.   JOURNAL OF NEUROSCIENCE

Macrophage toll-like receptor 9 contributes to chemotherapy-induced neuropathic pain in male mice

(2019) Xin Luo et al.   JOURNAL OF NEUROSCIENCE

Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties

(2019) Yang Zheng et al.   NEURON

Resolvin D5 Inhibits Neuropathic and Inflammatory Pain in Male But Not Female Mice: Distinct Actions of D-Series Resolvins in Chemotherapy-Induced Peripheral Neuropathy

(2019) Xin Luo et al.   Frontiers in Pharmacology

Interleukin-17 Regulates Neuron-Glial Communications, Synaptic Transmission, and Neuropathic Pain after Chemotherapy

(2019) Hao Luo et al.   Cell Reports

Undulating changes in human plasma proteome profiles across the lifespan

(2019) Benoit Lehallier et al.   NATURE MEDICINE

Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons

(2019) Ouyang Chen et al.   CURRENT OPINION IN NEUROBIOLOGY

Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice

(2018) Xin Luo et al.   BRAIN BEHAVIOR AND IMMUNITY

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

(2018) Sangsu Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats

(2018) Josiane C.S. Mapplebeck et al.   PAIN

Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn

(2018) Alexander Chamessian et al.   Scientific Reports

IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis

(2018) Yuzhu Hou et al.   Protein & Cell

Testosterone Decreases House Dust Mite–Induced Type 2 and IL-17A–Mediated Airway Inflammation

(2018) Hubaida Fuseini et al.   JOURNAL OF IMMUNOLOGY

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

(2018) Gang Chen et al.   NEURON

Mechanisms underlying mechanical sensitization induced by complement C5a

(2018) Charles A. Warwick et al.   PAIN

Estradiol Sensitizes the Transient Receptor Potential Vanilloid 1 Receptor in Pain Responses

(2017) Maja Payrits et al.   ENDOCRINOLOGY

Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel

(2017) Wonseok Chang et al.   Neuroscience Bulletin

Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes

(2017) Gang Chen et al.   Neuroscience Bulletin

Sex differences in peripheral not central immune responses to pain-inducing injury

(2017) Douglas M. Lopes et al.   Scientific Reports

Estrogen Receptor Beta Selective Agonists as Agents to Treat Chemotherapeutic-Induced Neuropathic Pain

(2016) Jian-Nong Ma et al.   ACS Chemical Neuroscience

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

(2016) Sarah Taves et al.   BRAIN BEHAVIOR AND IMMUNITY

Estrogens Exacerbate Nociceptive Pain via Up-Regulation of TRPV1 and ANO1 in Trigeminal Primary Neurons of Female Rats

(2016) Kazuaki Yamagata et al.   ENDOCRINOLOGY

Increased Serum Levels of IL-17A and IL-23 Are Associated with Decreased Vitamin D3 and Increased Pain in Osteoarthritis

(2016) Alireza Askari et al.   PLoS One

Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer

(2016) Yundong He et al.   Nature Communications

Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade

(2015) Zhen-Zhong Xu et al.   NATURE MEDICINE

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Specific targeting of the IL-23 receptor, using a novel small peptide noncompetitive antagonist, decreases the inflammatory response

(2014) Christiane Quiniou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter

(2014) Xing-Jun Liu et al.   CELL RESEARCH

IL-17-Producing Alveolar Macrophages Mediate Allergic Lung Inflammation Related to Asthma

(2014) C. Song et al.   JOURNAL OF IMMUNOLOGY

Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation

(2014) Lorena Riol-Blanco et al.   NATURE

Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota

(2014) V. F.-S. Shih et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-regulation of interleukin-23 induces persistent allodynia via CX3CL1 and interleukin-18 signaling in the rat spinal cord after tetanic sciatic stimulation

(2013) Chao Bian et al.   BRAIN BEHAVIOR AND IMMUNITY

Interleukin-17 sensitizes joint nociceptors to mechanical stimuli and contributes to arthritic pain through neuronal interleukin-17 receptors in rodents

(2012) Frank Richter et al.   ARTHRITIS AND RHEUMATISM

Spinal interleukin-17 promotes thermal hyperalgesia and NMDA NR1 phosphorylation in an inflammatory pain rat model

(2012) Xianze Meng et al.   PAIN

Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

(2011) R. E. Sorge et al.   JOURNAL OF NEUROSCIENCE

Potentiation of Excitatory Transmission in Substantia Gelatinosa Neurons of Rat Spinal Cord by Inhibition of Estrogen Receptor Alpha

(2011) Yan-Qing Zhong et al.   Molecular Pain

Spinal estrogen receptor alpha mediates estradiol-induced pronociception in a visceral pain model in the rat

(2011) Yaping Ji et al.   PAIN

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

(2009) L. van der Fits et al.   JOURNAL OF IMMUNOLOGY

Transient receptor potential channels: targeting pain at the source

(2008) Ardem Patapoutian et al.   NATURE REVIEWS DRUG DISCOVERY