Effective high-throughput isolation of fully human antibodies targeting infectious pathogens

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody

(2020) Philipp Schommers et al.   CELL

openPrimeR for multiplex amplification of highly diverse templates

(2020) Christoph Kreer et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor

(2020) Vincent Dussupt et al.   NATURE MEDICINE

Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies

(2020) Christoph Kreer et al.   Vaccines

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients

(2020) Christoph Kreer et al.   CELL

Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody

(2020) Mangaiarkarasi Asokan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

(2020) Thomas F. Rogers et al.   SCIENCE

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

(2020) Ching-Lin Hsieh et al.   SCIENCE

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV

(2020) Sebastian J. Theobald et al.   PLoS Pathogens

Structure-Based Vaccine Antigen Design

(2019) Barney S. Graham et al.   Annual Review of Medicine

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope

(2019) Till Schoofs et al.   IMMUNITY

Modeling the Amplification of Immunoglobulins through Machine Learning on Sequence-Specific Features

(2019) Matthias Döring et al.   Scientific Reports

Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study

(2019) Yehuda Z. Cohen et al.   PLoS One

Multiple Functions of B Cells in the Pathogenesis of Systemic Lupus Erythematosus

(2019) Kongyang Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV

(2019) Stefanie A. Ehrhardt et al.   NATURE MEDICINE

Antibodies to watch in 2020

(2019) Hélène Kaplon et al.   mAbs

Understanding B-cell activation and autoantibody repertoire selection in systemic lupus erythematosus: A B-cell immunomics approach

(2018) Christopher M. Tipton et al.   IMMUNOLOGICAL REVIEWS

The Increasingly Human and Profitable Monoclonal Antibody Market

(2018) António L. Grilo et al.   TRENDS IN BIOTECHNOLOGY

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

(2018) Pilar Mendoza et al.   NATURE

The Hemagglutinin A Stem Antibody MEDI8852 Prevents and Controls Disease and Limits Transmission of Pandemic Influenza Viruses

(2017) Catharine I Paules et al.   JOURNAL OF INFECTIOUS DISEASES

Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows

(2017) Devin Sok et al.   NATURE

Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever

(2017) Chad E Mire et al.   NATURE MEDICINE

Nanobodies® † †Nanobody is a registered trademark of Ablynx NV. as inhaled biotherapeutics for lung diseases

(2017) Gino Van Heeke et al.   PHARMACOLOGY & THERAPEUTICS

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

(2017) Jesper Pallesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

(2016) M. Gordon Joyce et al.   CELL

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth

(2016) Jinghe Huang et al.   IMMUNITY

Stable long-term cultures of self-renewing B cells and their applications

(2016) Mark J. Kwakkenbos et al.   IMMUNOLOGICAL REVIEWS

A novel antibody discovery platform identifies anti-influenza A broadly neutralizing antibodies from human memory B cells

(2016) Xiaodong Xiao et al.   mAbs

Sequencing and cloning of antigen-specific antibodies from mouse memory B cells

(2016) Lotta von Boehmer et al.   Nature Protocols

Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

(2016) Z. A. Bornholdt et al.   SCIENCE

Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection

(2016) K. Stettler et al.   SCIENCE

Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection

(2015) Laurent Detalle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus

(2015) Scott A. Smith et al.   Cell Host & Microbe

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

(2015) Nicole A. Doria-Rose et al.   JOURNAL OF VIROLOGY

Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus

(2015) Davide Corti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiviral Monoclonal Antibodies: Can They Be More Than Simple Neutralizing Agents?

(2015) Mireia Pelegrin et al.   TRENDS IN MICROBIOLOGY

Innate and Adaptive Immune Regulation During Chronic Viral Infections

(2015) Elina I. Zuniga et al.   Annual Review of Virology

Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity

(2014) Stylianos Bournazos et al.   CELL

Natural Antibodies Bridge Innate and Adaptive Immunity

(2014) Saswati Panda et al.   JOURNAL OF IMMUNOLOGY

Characteristics of Memory B Cells Elicited by a Highly Efficacious HPV Vaccine in Subjects with No Pre-existing Immunity

(2014) Erin M. Scherer et al.   PLoS Pathogens

Isolation of HIV-1-reactive antibodies using cell surface-expressed gp160ΔcBaL

(2013) Christian Gaebler et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Cross-neutralization of four paramyxoviruses by a human monoclonal antibody

(2013) Davide Corti et al.   NATURE

IgBLAST: an immunoglobulin variable domain sequence analysis tool

(2013) Jian Ye et al.   NUCLEIC ACIDS RESEARCH

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

(2013) Rogier W. Sanders et al.   PLoS Pathogens

Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies

(2012) Peter D. Kwong et al.   IMMUNITY

Nanobodies® Specific for Respiratory Syncytial Virus Fusion Protein Protect Against Infection by Inhibition of Fusion

(2011) Bert Schepens et al.   JOURNAL OF INFECTIOUS DISEASES

Antibody-based protection against HIV infection by vectored immunoprophylaxis

(2011) Alejandro B. Balazs et al.   NATURE

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

(2011) J. F. Scheid et al.   SCIENCE

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

(2011) D. Corti et al.   SCIENCE

Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies

(2010) Ron J. Keizer et al.   CLINICAL PHARMACOKINETICS

B cells in the pathogenesis and treatment of rheumatoid arthritis

(2010) Bethany Marston et al.   CURRENT OPINION IN RHEUMATOLOGY

The immunogenicity of humanized and fully human antibodies

(2010) Fiona A. Harding et al.   mAbs

High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies

(2009) Hua-Xin Liao et al.   JOURNAL OF VIROLOGICAL METHODS

Generation of stable monoclonal antibody–producing B cell receptor–positive human memory B cells by genetic programming

(2009) Mark J Kwakkenbos et al.   NATURE MEDICINE

Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen

(2009) Kenneth Smith et al.   Nature Protocols

A method for identification of HIV gp140 binding memory B cells in human blood

(2008) Johannes F. Scheid et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Conditional Immortalization of Human B Cells by CD40 Ligation

(2008) Martina Wiesner et al.   PLoS One

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

(2007) Thomas Tiller et al.   JOURNAL OF IMMUNOLOGICAL METHODS