Lysosome-targeting chimeras evolve

Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins

(2021) Yaxian Zhou et al.   ACS Central Science

LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

(2021) Green Ahn et al.   Nature Chemical Biology

Bifunctional small molecules that mediate the degradation of extracellular proteins

(2021) David F. Caianiello et al.   Nature Chemical Biology

Unifying principles of bifunctional, proximity-inducing small molecules

(2020) Christopher J. Gerry et al.   Nature Chemical Biology

Lysosome-targeting chimaeras for degradation of extracellular proteins

(2020) Steven M. Banik et al.   NATURE

Soluble ligands as drug targets

(2020) Misty M. Attwood et al.   NATURE REVIEWS DRUG DISCOVERY

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

(2019) Zhaoyang Li et al.   NATURE

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

(2019) Daiki Takahashi et al.   MOLECULAR CELL

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE