Resources, Production Scales and Time Required for Producing RNA Vaccines for the Global Pandemic Demand

Using microfluidics for scalable manufacturing of nanomedicines from bench to GMP: A case study using protein-loaded liposomes

(2020) Cameron Webb et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Current status of COVID‐19 (pre)clinical vaccine development

(2020) Bruno de Geest et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

(2020) Mark J. Mulligan et al.   NATURE

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

(2020) Paul F. McKay et al.   Nature Communications

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

(2020) Ugur Sahin et al.   NATURE

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

(2020) Edward E. Walsh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Paving the Road for RNA Therapeutics

(2020) Niels Dammes et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

COVID-19 vaccines poised for launch, but impact on pandemic unclear

(2020) Elie Dolgin   NATURE BIOTECHNOLOGY

Manufacturing Considerations for the Development of Lipid Nanoparticles Using Microfluidics

(2020) Carla B. Roces et al.   Pharmaceutics

Production of lentiviral vectors using novel, enzymatically produced, linear DNA

(2019) Rajvinder Karda et al.   GENE THERAPY

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

(2019) Kimberly J. Hassett et al.   Molecular Therapy-Nucleic Acids

Emerging Technologies for Low‐Cost, Rapid Vaccine Manufacture

(2019) Zoltán Kis et al.   Biotechnology Journal

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

(2019) Anna K. Blakney et al.   GENE THERAPY

Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems

(2018) Masatoshi Maeki et al.   ADVANCED DRUG DELIVERY REVIEWS

Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses

(2018) Annette B. Vogel et al.   MOLECULAR THERAPY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Plasmid DNA Manufacturing for Indirect and Direct Clinical Applications

(2017) Marco Schmeer et al.   HUMAN GENE THERAPY

Model Predictive Control of an Integrated Continuous Pharmaceutical Manufacturing Pilot Plant

(2017) Ali Mesbah et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Model-Based Methods in the Biopharmaceutical Process Lifecycle

(2017) Paul Kroll et al.   PHARMACEUTICAL RESEARCH

Quality by control: Towards model predictive control of mammalian cell culture bioprocesses

(2017) Wolfgang Sommeregger et al.   Biotechnology Journal

Self-replicating alphavirus RNA vaccines

(2014) Karl Ljungberg et al.   Expert Review of Vaccines

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

(2013) Martin A Maier et al.   MOLECULAR THERAPY

Nonviral delivery of self-amplifying RNA vaccines

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Developing mRNA-vaccine technologies

(2012) Thomas Schlake et al.   RNA Biology