Ginger, a Possible Candidate for the Treatment of Dementias?

From obesity to Alzheimer's disease through insulin resistance

(2021) Simona Terzo et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling

(2020) Lei Li et al.   Journal of Neuroinflammation

Biological and Computational Studies for Dual Cholinesterases Inhibitory Effect of Zerumbone

(2020) Jayeong Hwang et al.   Nutrients

Phytosome Loading the Combined Extract of Mulberry Fruit and Ginger Protects against Cerebral Ischemia in Metabolic Syndrome Rats

(2020) Nut Palachai et al.   Oxidative Medicine and Cellular Longevity

Memory-Enhancing Effect of a Phytosome Containing the Combined Extract of Mulberry Fruit and Ginger in an Animal Model of Ischemic Stroke with Metabolic Syndrome

(2020) Jintanaporn Wattanathorn et al.   Oxidative Medicine and Cellular Longevity

Oxygen glucose deprivation/re-oxygenation-induced neuronal cell death is associated with Lnc-D63785 m6A methylation and miR-422a accumulation

(2020) Shu Xu et al.   Cell Death & Disease

Alzheimer’s Disease as a Result of Stimulus Reduction in a GABA-A-Deficient Brain: A Neurocomputational Model

(2020) Mariana Antonia Aguiar-Furucho et al.   NEURAL PLASTICITY

Zingiber officinale ameliorates Alzheimer’s disease and Cognitive Impairments: Lessons from preclinical studies

(2020) Marjan Talebi et al.   BIOMEDICINE & PHARMACOTHERAPY

Ginger ( Zingiber officinale Roscoe) as a nutraceutical: Focus on the metabolic, analgesic, and antiinflammatory effects

(2020) Ester Pagano et al.   PHYTOTHERAPY RESEARCH

Exosome-like Nanoparticles from Ginger Rhizomes Inhibited NLRP3 Inflammasome Activation

(2019) Xingyi Chen et al.   MOLECULAR PHARMACEUTICS

A molecular modeling study of components of the ginger (Zingiber officinale) extract inside human butyrylcholinesterase: implications for Alzheimer disease

(2019) Teobaldo Cuya et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe)

(2019) Qian-Qian Mao et al.   Foods

Dementia

(2018) Seth A. Gale et al.   AMERICAN JOURNAL OF MEDICINE

Neuroprotective Effect and Molecular Mechanism of [6]-Gingerol against Scopolamine-Induced Amnesia in C57BL/6 Mice

(2018) Chang-Yul Kim et al.   Evidence-based Complementary and Alternative Medicine

Comparison of Inhibitory Capacities of 6-, 8- and 10-Gingerols/Shogaols on the Canonical NLRP3 Inflammasome-Mediated IL-1β Secretion

(2018) et al.   MOLECULES

Pharmacotherapeutic potential of ginger and its compounds in age-related neurological disorders

(2018) Jin Gyu Choi et al.   PHARMACOLOGY & THERAPEUTICS

Protective and therapeutic potential of ginger (Zingiber officinale ) extract and [6]-gingerol in cancer: A comprehensive review

(2018) Rosália Maria Tôrres de Lima et al.   PHYTOTHERAPY RESEARCH

Ginger fermented with Schizosaccharomyces pombe alleviates memory impairment via protecting hippocampal neuronal cells in amyloid beta1–42 plaque injected mice

(2018) Eugene Huh et al.   Food & Function

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

(2018) Md. Sahab Uddin et al.   Frontiers in Aging Neuroscience

Effects of Altered Cerebral Hemodynamics on Cognitive Function

(2018) Randolph S. Marshall   JOURNAL OF ALZHEIMERS DISEASE

Heat-induced conversion of gingerols to shogaols in ginger as affected by heat type (dry or moist heat), sample type (fresh or dried), temperature and time

(2017) Mun Yhung Jung et al.   FOOD SCIENCE AND BIOTECHNOLOGY

A molecular dynamics study of components of the ginger (Zingiber officinale) extract inside human acetylcholinesterase: implications for Alzheimer disease

(2017) Teobaldo Cuya et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta - secretases and APH1a

(2017) Ali M. El Halawany et al.   Scientific Reports

Simple In Vitro Assays to Identify Amyloid-β Aggregation Blockers for Alzheimer's Disease Therapy

(2017) Jian-Ping Guo et al.   JOURNAL OF ALZHEIMERS DISEASE

6-Shogaol has anti-amyloidogenic activity and ameliorates Alzheimer’s disease via CysLT1R-mediated inhibition of cathepsin B

(2016) Ji-Young Na et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview

(2016) Rosaliana Libro et al.   MOLECULES

Tau: The Center of a Signaling Nexus in Alzheimer's Disease

(2016) Shahzad S. Khan et al.   Frontiers in Neuroscience

AnIn VitroSystem Comprising Immortalized Hypothalamic Neuronal Cells (GT1–7 Cells) for Evaluation of the Neuroendocrine Effects of Essential Oils

(2015) Dai Mizuno et al.   Evidence-based Complementary and Alternative Medicine

Blood-brain barrier damage in vascular dementia

(2015) Masaki Ueno et al.   NEUROPATHOLOGY

The Role of 6-Gingerol on Inhibiting Amyloid β Protein-Induced Apoptosis in PC12 Cells

(2015) Gao-feng Zeng et al.   REJUVENATION RESEARCH

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Neuroprotective Effect of 6-Paradol in Focal Cerebral Ischemia Involves the Attenuation of Neuroinflammatory Responses in Activated Microglia

(2015) Bhakta Prasad Gaire et al.   PLoS One

6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia

(2014) Minho Moon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Houshiheisan compound prescription protects neurovascular units after cerebral ischemia

(2014) Hui Zhao et al.   Neural Regeneration Research

Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer’s drugs: a computational investigation

(2014) Faizul Azam et al.   Drug Design Development and Therapy

Enzyme-assisted extraction of bioactive compounds from ginger (Zingiber officinale Roscoe)

(2013) K.L. Nagendra chari et al.   FOOD CHEMISTRY

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Protective Effects of Ginger Root Extract on Alzheimer Disease-Induced Behavioral Dysfunction in Rats

(2013) Gao-feng Zeng et al.   REJUVENATION RESEARCH

Oxidative stress and cerebral endothelial cells: Regulation of the blood–brain-barrier and antioxidant based interventions

(2011) Linnea R. Freeman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

[6]-Gingerol attenuates β-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense system

(2011) Chan Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Vascular Contributions to Cognitive Impairment and Dementia

(2011) Philip B. Gorelick et al.   STROKE

Alzheimer's disease, a multifactorial disorder seeking multitherapies

(2010) Khalid Iqbal et al.   Alzheimers & Dementia

Zingiber officinaleMitigates Brain Damage and Improves Memory Impairment in Focal Cerebral Ischemic Rat

(2010) Jintanaporn Wattanathorn et al.   Evidence-based Complementary and Alternative Medicine

Modulation of age-related NF-κB activation by dietary zingerone via MAPK pathway

(2010) Mi Kyung Kim et al.   EXPERIMENTAL GERONTOLOGY

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2009) David Moher et al.   PLOS MEDICINE

5-Lipoxygenase: mechanisms of regulation

(2008) Olof Rådmark et al.   JOURNAL OF LIPID RESEARCH

Muscarinic, Ca++ antagonist and specific butyrylcholinesterase inhibitory activity of dried ginger extract might explain its use in dementia

(2008) Muhammad N. Ghayur et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON