Thiazole Ring—A Biologically Active Scaffold

Synthesis, Anti-convulsant activity and Molecular Docking Study of novel Thiazole Pyridazinone Hybrid Analogues

(2020) Aness Ahmad Siddiqui et al.   BIOORGANIC CHEMISTRY

Novel 2,4-Disubstituted-1,3-Thiazole Derivatives: Synthesis, Anti-Candida Activity Evaluation and Interaction with Bovine Serum Albumine

(2020) Andreea-Iulia Pricopie et al.   MOLECULES

Cyclization of Active Methylene Isocyanides with α-Oxodithioesters Induced by Base: An Expedient Synthesis of 4-Methylthio/Ethoxycarbonyl-5-acylthiazoles

(2020) Kuppalli R. Kiran et al.   SYNTHESIS-STUTTGART

Identification of protein tyrosine phosphatase 1B (PTP1B) inhibitors through De Novo Evoluton, synthesis, biological evaluation and molecular dynamics simulation

(2020) Jingwei Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vitro studies of potent aldose reductase inhibitors: Synthesis, characterization, biological evaluation and docking analysis of rhodanine-3-hippuric acid derivatives

(2020) Stephen Kumar Celestina et al.   BIOORGANIC CHEMISTRY

Design and Synthesis of a Library of Thiazolidin‐4‐one Derivatives as Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors: An Attempt to Discover Novel Anti‐diabetic Agents

(2020) Rati Kailash Prasad Tripathi et al.   ChemMedChem

Synthesis, modelling and molecular docking of new 5-arylazo-2-chloroacetamido thiazole derivatives as antioxidant agent

(2020) Aisha SM. Hossan   JOURNAL OF MOLECULAR STRUCTURE

Study of in vitro biological activity of thiazoles on Leishmania (Leishmania) infantum

(2020) Vinícius Vasconcelos Gomes de Oliveira et al.   Journal of Global Antimicrobial Resistance

Synthesis and Biological Evaluation of Imidazo[2,1-b]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors

(2020) Kesari Lakshmi Manasa et al.   Metabolites

Determination of the inhibition profiles of pyrazolyl–thiazole derivatives against aldose reductase and α‐glycosidase and molecular docking studies

(2020) Yeliz Demir et al.   ARCHIV DER PHARMAZIE

Identification and development of thiazole leads as COX-2/5-LOX inhibitors through in-vitro and in-vivo biological evaluation for anti-inflammatory activity

(2020) Jaismy Jacob P et al.   BIOORGANIC CHEMISTRY

Design, synthesis, and biological evaluation of chalcone-linked thiazole-imidazopyridine derivatives as anticancer agents

(2020) Vellanki Ragha Suma et al.   MEDICINAL CHEMISTRY RESEARCH

Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds

(2020) Belgin Sever et al.   BIOORGANIC CHEMISTRY

An extensive research on aldose reductase inhibitory effects of new 4H-1,2,4-triazole derivatives

(2020) Belgin Sever et al.   JOURNAL OF MOLECULAR STRUCTURE

Pyridine- and Thiazole-Based Hydrazides with Promising Anti-inflammatory and Antimicrobial Activities along with Their In Silico Studies

(2020) Vinuta Kamat et al.   ACS Omega

Synthesis and biological evaluation of anti-tubercular activity of Schiff bases of 2-Amino thiazoles

(2020) Rachel Cordeiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Assessing different thiazolidine and thiazole based compounds as antileishmanial scaffolds

(2020) Ermin Schadich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Molecular Docking of Paracyclophanyl-Thiazole Hybrids as Novel CDK1 Inhibitors and Apoptosis Inducing Anti-Melanoma Agents

(2020) Ashraf A. Aly et al.   MOLECULES

Microwave irradiated one pot, three component synthesis of a new series of hybrid coumarin based thiazoles: Antibacterial evaluation and molecular docking studies

(2020) Srikanth Mamidala et al.   JOURNAL OF MOLECULAR STRUCTURE

One-Pot Three-Component Strategy for Polysubstituted 2-Aminothiazoles via Ring Opening of α-Nitro Epoxides

(2019) Guolin Zhang et al.   SYNTHESIS-STUTTGART

Synthesis and biological evaluation of 5-methyl-4-phenyl thiazole derivatives as anticancer agents

(2019) Asaf E. Evren et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Synthesis and Biological Evaluation of Some Novel Thiazole-Based Heterocycles as Potential Anticancer and Antimicrobial Agents

(2019) Sraa Abu-Melha et al.   MOLECULES

Synthesis of 5-enamine-4-thiazolidinone derivatives with trypanocidal and anticancer activity

(2019) Serhii Holota et al.   BIOORGANIC CHEMISTRY

Design, synthesis and molecular docking of pyrazolo [3,4d] thiazole hybrids as potential anti-HIV-1 NNRT inhibitors

(2019) H.M. Kasralikar et al.   BIOORGANIC CHEMISTRY

Synthesis and antimycobacterial evaluation of new 5-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-methyl-2-arylthiazole derivatives

(2019) Vikas Shinde et al.   MEDICINAL CHEMISTRY RESEARCH

New Series of Thiazole Derivatives: Synthesis, Structural Elucidation, Antimicrobial Activity, Molecular Modeling and MOE Docking

(2019) Ismail Althagafi et al.   MOLECULES

In silico ADMET study, docking, synthesis and antimalarial evaluation of thiazole-1,3,5-triazine derivatives as Pf-DHFR inhibitor

(2019) Supriya Sahu et al.   Pharmacological Reports

Synthesis and biological evaluation of purine-pyrazole hybrids incorporating thiazole, thiazolidinone or rhodanine moiety as 15-LOX inhibitors endowed with anticancer and antioxidant potential

(2019) Ola S. Afifi et al.   BIOORGANIC CHEMISTRY

Thiazolidinone/thiazole based hybrids – New class of antitrypanosomal agents

(2019) Anna Kryshchyshyn et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New one-pot synthesis of 2-ylidenehydrazono-thiazoles

(2019) Ashraf A. Aly et al.   Journal of Sulfur Chemistry

Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease

(2019) Sebastian Steven et al.   Oxidative Medicine and Cellular Longevity

Synthesis of (Z)-5-(substituted benzylidene)-2-((substituted phenyl) amino)thiazol-4(5H)-one analogues with antitubercular activity

(2019) Rohini N. Shelke et al.   Journal of Taibah University for Science

Synthesis and biological evaluation of 2,4,5-trisubstituted thiazoles as antituberculosis agents effective against drug-resistant tuberculosis

(2019) Uttam B. Karale et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, biological evaluation and molecular dynamics studies of 4-thiazolinone derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors

(2019) Wen-Shan Liu et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Synthesis of 2-Amino-5-acylthiazoles by a Tertiary Amine-Promoted One-Pot Three-Component Cascade Cyclization Using Elemental Sulfur as a Sulfur Source

(2019) Rong-Geng Fu et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis, antimicrobial activity, and determination of the lipophilicity of ((cyclohex-3-enylmethylene)hydrazinyl)thiazole derivatives

(2019) Anna Biernasiuk et al.   MEDICINAL CHEMISTRY RESEARCH

Design and Synthesis of Novel 1,3-Thiazole and 2-Hydrazinyl-1,3-Thiazole Derivatives as Anti-Candida Agents: In Vitro Antifungal Screening, Molecular Docking Study, and Spectroscopic Investigation of their Binding Interaction with Bovine Serum Albumin

(2019) Andreea-Iulia Pricopie et al.   MOLECULES

Synthesis and biological evaluations of novel isoxazoles and furoxan derivative as anti-inflammatory agents

(2019) Eman K.A. Abdelall   BIOORGANIC CHEMISTRY

Novel Thiazolidin-4-ones as Potential Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase

(2019) Petrou et al.   MOLECULES

In vitro activity of aryl-thiazole derivatives against Schistosoma mansoni schistosomula and adult worms

(2019) Adriana S. A. Pereira et al.   PLoS One

Imidazo[2,1-b]thiazole-Coupled Natural Noscapine Derivatives as Anticancer Agents

(2019) Praveen Kumar Reddy Nagireddy et al.   ACS Omega

Design and synthesis of novel Imidazo[2,1-b]thiazole derivatives as potent antiviral and antimycobacterial agents

(2019) Elif Gürsoy et al.   BIOORGANIC CHEMISTRY

Some Thiazole Derivatives Combined With Different Heterocycles : Cytotoxicity Evaluation And Apoptosis Inducing Studies

(2018) Leyla Yurttas et al.   Anti-Cancer Agents in Medicinal Chemistry

Biological Activity Evaluation of Novel 1,2,4-Triazine Derivatives Containing Thiazole/Benzothiazole Rings

(2018) Leyla Yurttas et al.   Anti-Cancer Agents in Medicinal Chemistry

Thiazole-substituted benzenesulfonamides as inhibitors of 12 human carbonic anhydrases

(2018) Edita Čapkauskaitė et al.   BIOORGANIC CHEMISTRY

In vitro antioxidant activity of thiazolidinone derivatives of 1,3-thiazole and 1,3,4-thiadiazole

(2018) Mirjana Djukic et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives

(2018) Cleudiomar Inácio Lino et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluations of novel pyridone-thiazole hybrid molecules as antitumor agents

(2018) Wenlin Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA)

(2018) Mohamed M. Elsebaei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and screening of 1, 2, 4-triazinone derivatives as potential antitumor agents with apoptosis inducing activity on MCF-7 breast cancer cell line

(2018) Islam Zaki et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anticancer activity and mechanism of action of new thiazole derivatives

(2018) Temístocles Italo de Santana et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship

(2018) Toshiaki Aoki et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cefiderocol: a novel siderophore cephalosporin

(2018) Justin J Choi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Thiazoles with cyclopropyl fragment as antifungal, anticonvulsant, and anti-Toxoplasma gondii agents: synthesis, toxicity evaluation, and molecular docking study

(2018) Krzysztof Z. Łączkowski et al.   MEDICINAL CHEMISTRY RESEARCH

Cu-Catalyzed Aerobic Oxidative Sulfuration/Annulation Approach to Thiazoles via Multiple Csp3–H Bond Cleavage

(2018) Xiaoyang Wang et al.   ORGANIC LETTERS

Docking analysis targeted to the whole enzyme: an application to the prediction of inhibition of PTP1B by thiomorpholine and thiazolyl derivatives

(2018) C. A. Ganou et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Synthesis and evaluation of some new 5-(hetaryl)thiazoles as potential antimicrobial agents

(2018) Samir Bondock et al.   SYNTHETIC COMMUNICATIONS

Targeting Tumor Associated Carbonic Anhydrases IX and XII: Highly Isozyme Selective Coumarin and Psoralen Inhibitors

(2018) Claudia Melis et al.   ACS Medicinal Chemistry Letters

Synthesis and evaluation of thiazolidine-2,4-dione/benzazole derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B): Antihyperglycemic activity with molecular docking study

(2018) Sergio Hidalgo-Figueroa et al.   BIOMEDICINE & PHARMACOTHERAPY

4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents

(2018) Carina Agostinho Rodrigues et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

A Review on Recent Synthetic Strategies and Pharmacological Importance of 1,3-Thiazole Derivatives

(2018) Swarna Gowri et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

One-Pot Telescoped Synthesis of Thiazole Derivatives from β-Keto Esters and Thioureas Promoted by Tribromoisocyanuric Acid

(2018) Marcio de Mattos et al.   SYNTHESIS-STUTTGART

Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides

(2018) Rita Meleddu et al.   ACS Medicinal Chemistry Letters

Synthesis of novel derivatives of 7,8-dihydro-6H -imidazo[2,1-b ][1,3]benzothiazol-5-one and their virus-inhibiting activity against influenza A virus

(2018) Anastasia V. Galochkina et al.   ARCHIV DER PHARMAZIE

Synthesis and biological evaluation of thiazole derivatives as LbSOD inhibitors

(2018) Camila C. Bitencourt Brito et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, double-blind, non-inferiority trial

(2018) Simon Portsmouth et al.   LANCET INFECTIOUS DISEASES

Design, Synthesis, and Anticancer Activities of Novel 2-Amino-4-phenylthiazole Scaffold Containing Amide Moieties

(2018) Zhi-Hua Zhang et al.   Journal of Chemistry

Design, synthesis and biological evaluation of novel β-pinene-based thiazole derivatives as potential anticancer agents via mitochondrial-mediated apoptosis pathway

(2018) Yunyun Wang et al.   BIOORGANIC CHEMISTRY

New benzimidazothiazole derivatives as anti-inflammatory, antitumor active agents: Synthesis, in-vitro and in-vivo screening and molecular modeling studies

(2018) Mohamed M. El-Kerdawy et al.   BIOORGANIC CHEMISTRY

Desing and synthesis of potent anti - Trypanosoma cruzi agents new thiazoles derivatives which induce apoptotic parasite death

(2017) Elany Barbosa da Silva et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy

(2017) Saeed Emami et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity

(2017) Mostafa H. Abdelrahman et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents

(2017) Rosaria Ottanà et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural design, synthesis and pharmacological evaluation of thiazoles against Trypanosoma cruzi

(2017) Gevanio Bezerra de Oliveira Filho et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In vitro evaluation of cytotoxicity and leishmanicidal activity of phthalimido-thiazole derivatives

(2017) Amanda Silva dos Santos Aliança et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides

(2017) Morteza Abdoli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Investigating the Antibacterial Activity of Biphenylthiazoles against Methicillin- and Vancomycin-Resistant Staphylococcus aureus (MRSA and VRSA)

(2017) Mohamed Hagras et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antioxidant and antimicrobial activities of novel thiopyrano[2,3-d]thiazoles based on aroylacrylic acids

(2017) Andrii Lozynskyi et al.   MOLECULAR DIVERSITY

COX Inhibition Profile and Molecular Docking Studies of Some 2-(Trimethoxyphenyl)-Thiazoles

(2017) Smaranda Oniga et al.   MOLECULES

Cytotoxicity and Antioxidant Potential of Novel 2-(2-((1H-indol-5yl)methylene)-hydrazinyl)-thiazole Derivatives

(2017) Adriana Grozav et al.   MOLECULES

Synthesis of chalcone incorporated quinazoline derivatives as anticancer agents

(2017) Sapavat Madhavi et al.   SAUDI PHARMACEUTICAL JOURNAL

N-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms

(2017) Giulia Bianco et al.   ACS Medicinal Chemistry Letters

Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data

(2017) Michèle Bally et al.   BMJ-British Medical Journal

Synthesis of 2-phenylamino-thiazole derivatives as antimicrobial agents

(2017) Dominique Serge Ngono Bikobo et al.   Journal of Saudi Chemical Society

Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data

(2017) Michèle Bally et al.   BMJ-British Medical Journal

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

(2017) Sook-Kwan Leang et al.   Jove-Journal of Visualized Experiments

Fluconazole resistance in Candida species: a current perspective

(2017) Elizabeth Berkow et al.   Infection and Drug Resistance

Synthesis and Carbonic Anhydrase Inhibition of Novel 2-(4-(Aryl)thiazole-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione Derivatives

(2016) Umit M. Kocyigit et al.   ARCHIV DER PHARMAZIE

Incidence and Mortality and Epidemiology of Breast Cancer in the World

(2016) Mahshid Ghoncheh et al.   Asian Pacific Journal of Cancer Prevention

Novel sulfonamide bearing coumarin scaffolds as selective inhibitors of tumor associated carbonic anhydrase isoforms IX and XII

(2016) Navneet Chandak et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense

(2016) Donald A. Patrick et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies

(2016) Fabrizio Carta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of novel 2-aminothiazole conjugated nitrofuran as antitubercular and antibacterial agents

(2016) Kai Ran et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and antimalarial evaluation of novel thiazole derivatives

(2016) José María Bueno et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and carbonic anhydrase inhibitory properties of novel chalcone substituted benzenesulfonamides

(2016) Tayfun Arslan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyridazinone substituted benzenesulfonamides as potent carbonic anhydrase inhibitors

(2016) Raed Yaseen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Coumarin-thiazole and -oxadiazole derivatives: Synthesis, bioactivity and docking studies for aldose/aldehyde reductase inhibitors

(2016) Aliya Ibrar et al.   BIOORGANIC CHEMISTRY

Synthesis and cytotoxicity evaluation of thiosemicarbazones and their thiazole derivatives

(2016) Saulo Feheiberg Pinto Braga et al.   Brazilian Journal of Pharmaceutical Sciences

Synthesis, Antitumor and Anti-inflammatory Activities of Isolongifolanonyl Pyrazole Derivatives

(2016) Jian Rui et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Synthesis and in silico investigation of thiazoles bearing pyrazoles derivatives as anti-inflammatory agents

(2016) Rahul D. Kamble et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

New 1,3-thiazole derivatives and their biological and ultrastructural effects on Trypanosoma cruzi

(2016) Paulo André Teixeira de Moraes Gomes et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents

(2016) Gülhan Turan-Zitouni et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I

(2016) Ge Meng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multidrug-Resistant Bacteria in the Community

(2016) David van Duin et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase

(2016) Rita Meleddu et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and evaluation of sulfonamide-bearing thiazole as carbonic anhydrase isoforms hCA I and hCA II

(2016) Soner Kılıcaslan et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and anticonvulsant activities of novel 2-(cyclopentylmethylene)hydrazinyl-1,3-thiazoles in mouse models of seizures

(2016) Krzysztof Z. Łączkowski et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis, antimicrobial and anticonvulsant screening of small library of tetrahydro-2H-thiopyran-4-yl based thiazoles and selenazoles

(2016) Krzysztof Z. Łączkowski et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors

(2016) Claudia Melis et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties

(2016) Mohammed A. Seleem et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antimicrobial evaluation and theoretical prediction of NMR chemical shifts of thiazole and selenazole derivatives with high antifungal activity against Candida spp.

(2016) Krzysztof Z. Łączkowski et al.   JOURNAL OF MOLECULAR STRUCTURE

Access to Thiazole via Copper-Catalyzed [3+1+1]-Type Condensation Reaction under Redox-Neutral Conditions

(2016) Xiaodong Tang et al.   JOURNAL OF ORGANIC CHEMISTRY

Understanding the mechanisms and drivers of antimicrobial resistance

(2016) Alison H Holmes et al.   LANCET

Modified Hummel-Dreyer Method and Molecular Modeling Studies Identified Nicotinic Acid Analogues as Carbonic Anhydrase III Ligands

(2016) Nada Jarrar et al.   Letters in Drug Design & Discovery

Copper-Catalyzed Coupling of Oxime Acetates with Isothiocyanates: A Strategy for 2-Aminothiazoles

(2016) Xiaodong Tang et al.   ORGANIC LETTERS

Visceral Leishmaniasis in Southwestern Iran: A Retrospective Clinico-Hematological Analysis of 380 Consecutive Hospitalized Cases (1999–2014)

(2016) Bahador Sarkari et al.   PLoS One

Molecular docking assisted 3D-QSAR study of benzylidene-2,4-thiazolidinedione derivatives as PTP-1B inhibitors for the management of Type-2 diabetes mellitus

(2016) Sant K. Verma et al.   RSC Advances

Synthesis and study of 1,3,5-triazine based thiazole derivatives as antimicrobial agents

(2016) N.C. Desai et al.   Journal of Saudi Chemical Society

In VitroAntimalarial Activity of Novel Semisynthetic Nocathiacin I Antibiotics

(2015) Indu Sharma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Radioiodination of 2,3-dimethyl-4 H -furo[3,2- c ]coumarin and biological evaluation in solid tumor bearing mice

(2015) S.M. Abd Elhalim et al.   APPLIED RADIATION AND ISOTOPES

Synthesis and Determination of Some Biological Activities of Novel 2,4-Dinitrophenyl Derivatives

(2015) Sevim B. Öztürk Sarikaya et al.   ARCHIV DER PHARMAZIE

Design, Synthesis, and Anti-Inflammatory Evaluation of Novel Diphenylthiazole-Thiazolidinone Hybrids

(2015) Ahmed H. Abdelazeem et al.   ARCHIV DER PHARMAZIE

Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives

(2015) İsmail Fidan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII

(2015) Alessio Nocentini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa

(2015) Melissa A. Pinard et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of pyrazolylthiazole carboxylic acids as potent anti-inflammatory–antimicrobial agents

(2015) Poonam Khloya et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII

(2015) Rita Meleddu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Thiazole: A promising heterocycle for the development of potent CNS active agents

(2015) Chandra Bhushan Mishra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bioactive thiazole and benzothiazole derivatives

(2015) Abdul Rouf et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antibacterial evaluation of a novel series of synthetic phenylthiazole compounds against methicillin-resistant Staphylococcus aureus (MRSA)

(2015) Haroon Mohammad et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiviral activity of some new bis-1,3-thiazole derivatives

(2015) Kamal M. Dawood et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent applications of 1,3-thiazole core structure in the identification of new lead compounds and drug discovery

(2015) Adile Ayati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel 2-(1H-imidazol-2-ylmethylidene)hydrazinyl- 1,3-thiazoles as potential antimicrobial agents

(2015) Krzysztof Z. Łączkowski et al.   HETEROCYCLIC COMMUNICATIONS

Chemical and biological metal nanoparticles as antimycobacterial agents: A comparative study

(2015) Richa Singh et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Design, synthesis, antimicrobial evaluation and molecular docking studies of some new 2,3-dihydrothiazoles and 4-thiazolidinones containing sulfisoxazole

(2015) Tamer Nasr et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis, biological evaluation and molecular docking studies of thiazole-based pyrrolidinones and isoindolinediones as anticonvulsant agents

(2015) Hazem A. Ghabbour et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and activity of (+)-usnic acid and (−)-usnic acid derivatives containing 1,3-thiazole cycle against Mycobacterium tuberculosis

(2015) Olga B. Bekker et al.   MEDICINAL CHEMISTRY RESEARCH

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation

(2015) Cristina Nastasă et al.   MOLECULES

Facile Synthesis of 2,5-Disubstituted Thiazoles from Terminal Alkynes, Sulfonyl Azides, and Thionoesters

(2015) Tomoya Miura et al.   ORGANIC LETTERS

Selective Access to 4-Substituted 2-Aminothiazoles and 4-Substituted 5-Thiocyano-2-aminothiazoles from Vinyl Azides and Potassium Thiocyanate Switched by Palladium and Iron Catalysts

(2015) Binhui Chen et al.   ORGANIC LETTERS

Tuberculosis: A disease without boundaries

(2015) Nicole Fogel   TUBERCULOSIS

Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents

(2015) Jian Tang et al.   ACS Medicinal Chemistry Letters

Synthesis and biological evaluation of some 4-(6-substituted-1,3-benzothiazol-2-yl)amino-1,3-thiazole-2-amines and their Schiff bases

(2015) Nikhil D. Amnerkar et al.   Arabian Journal of Chemistry

Discovery of novel 1,3,5-triazine-thiazolidine-2,4-diones as dipeptidyl peptidase-4 inhibitors with antibacterial activity targeting the S1 pocket for the treatment of type 2 diabetes

(2015) Jitendra Kumar Srivastava et al.   RSC Advances

A facile, solvent and catalyst free, microwave assisted one pot synthesis of hydrazinyl thiazole derivatives

(2015) D. Chinnaraja et al.   Journal of Saudi Chemical Society

Synthesis of Some New Thiazole Derivatives and Their Biological Activity Evaluation

(2015) Leyla Yurttaş et al.   Journal of Chemistry

Synthesis and Antibacterial, Antitumor Activity of 2,6,6-Thrimethyl- bicyclo[3,1,1]heptan-3-(4-aryl-2-thiazoyl)hydrazones

(2015) Mingkai Bao et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Engineering More Stable, Selectable Marker-Free Autoluminescent Mycobacteria by One Step

(2015) Feng Yang et al.   PLoS One

Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway

(2015) Bahityar Rahmutulla et al.   Oncotarget

Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I–XIV

(2014) Mariangela Ceruso et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2-Acylamino-5-nitro-1,3-thiazoles: Preparation and in vitro bioevaluation against four neglected protozoan parasites

(2014) Carlos Nava-Zuazo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

An Efficient One-pot Synthesis of Aryl-substituted 1-(Thiazol-2-yl)-1H-pyrazole-3-carboxylates via a Hantzsch Synthesis-Knorr Reaction Sequence

(2014) Chunhui Gu et al.   CHINESE JOURNAL OF CHEMISTRY

2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: Structural design, synthesis and pharmacological evaluation

(2014) Marcos Veríssimo de Oliveira Cardoso et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, structure–activity relationships, and in vitro antibacterial and antifungal activity evaluations of novel pyrazole carboxylic and dicarboxylic acid derivatives

(2014) Samet Mert et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of thiazoline derivatives as new antimicrobial and anticancer agents

(2014) Mehlika Dilek Altıntop et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chromatographic evaluation and QSAR optimization for benzoic acid analogues against carbonic anhydrase III

(2014) Muhammed Alzweiri et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and biological activity of novel thiourea derivatives as carbonic anhydrase inhibitors

(2014) Neslihan Korkmaz et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery and Characterization of Potent Thiazoles versus Methicillin- and Vancomycin-Resistant Staphylococcus aureus

(2014) Haroon Mohammad et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antioxidant, and cytotoxic activities of bis(oxazolyl/thiazolyl/imidazolyl)amidomethanesulfonyl Acetamides

(2014) Putta Ramachandra Reddy et al.   MEDICINAL CHEMISTRY RESEARCH

Design, synthesis, characterization, antioxidant and in vitro cytotoxic activities of novel coumarin thiazole derivatives

(2014) Sreekanth Thota et al.   MEDICINAL CHEMISTRY RESEARCH

The Effect of Some 4,2 and 5,2 Bisthiazole Derivatives on Nitro-Oxidative Stress and Phagocytosis in Acute Experimental Inflammation

(2014) Cătălin Araniciu et al.   MOLECULES

Synthesis and in Vitro Evaluation of New Nitro-Substituted Thiazolyl Hydrazone Derivatives as Anticandidal and Anticancer Agents

(2014) Mehlika Altıntop et al.   MOLECULES

Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and OAT3

(2014) Jianghao Ye et al.   Pharmacological Reports

Transport Rankings of Non-Steroidal Antiinflammatory Drugs across Blood-Brain Barrier In Vitro Models

(2014) Iveta Novakova et al.   PLoS One

Characteristics and clinical outcome of nonsteroidal anti-inflammatory drug-induced acute hepato-nephrotoxicity among Chinese patients

(2014) Ya-Li Cao   WORLD JOURNAL OF GASTROENTEROLOGY

Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry

(2014) Nicolino Pala et al.   ACS Medicinal Chemistry Letters

“On-water” synthesis of novel trisubstituted 1,3-thiazoles via microwave-assisted catalyst-free domino reactions

(2014) Shaik Karamthulla et al.   RSC Advances

Dissecting Cytochrome P450 3A4–Ligand Interactions Using Ritonavir Analogues

(2013) Irina F. Sevrioukova et al.   BIOCHEMISTRY

Second-Generation Tyrosine Kinase Inhibitors in First-Line Treatment of Chronic Myeloid Leukaemia (CML)

(2013) Elisabetta Abruzzese et al.   BIODRUGS

Evaluation of vanillic acid as inhibitor of carbonic anhydrase isozyme III by using a modified Hummel-Dreyer method: approach for drug discovery

(2013) Muhammed Alzweiri et al.   BIOMEDICAL CHROMATOGRAPHY

Synthesis, biological activity and structure–activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells

(2013) Rosaria Ottanà et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A novel formulation of thiamine dilaurylsulphate and its preservative effect on apple juice and sterilised milk

(2013) Lina Wei et al.   FOOD CHEMISTRY

Antipsychotic agents screened as human carbonic anhydrase I and II inhibitors

(2013) Mahmut Erzengin et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Antitumor activity of novel pyridine, thiophene and thiazole derivatives

(2012) Mostafa M. Ghorab et al.   ARCHIVES OF PHARMACAL RESEARCH

Substituted thiazoles VII. Synthesis and antitumor activity of certain 2-(substituted amino)-4-phenyl-1,3-thiazole analogs

(2012) Ghada S. Hassan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis

(2012) L. Ouyang et al.   CELL PROLIFERATION

New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells

(2012) Rosaria Ottanà et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and carbonic anhydrase inhibitory properties of novel coumarin derivatives

(2012) Mert Olgun Karatas et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

A New Promising Application for Highly Cytotoxic Metal Compounds: η6-Areneruthenium(II) Phosphite Complexes for the Treatment of Alveolar Echinococcosis

(2012) Tatiana Küster et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analogue-based design, synthesis and molecular docking analysis of 2,3-diaryl quinazolinones as non-ulcerogenic anti-inflammatory agents

(2011) E. Manivannan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New thiazole carboxamides as potent inhibitors of Akt kinases

(2011) Shaohua Chang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure–activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI

(2011) Deniz Ekinci et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Convergent Synthesis and Biological Evaluation of 2-Amino-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl Thiazoles as Microtubule Targeting Agents

(2011) Romeo Romagnoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-breast cancer activity of some novel 1,2-dihydropyridine, thiophene and thiazole derivatives

(2010) Mansour S. Al-Said et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A novel screening method based on menadione mediated rapid reduction of tetrazolium salt for testing of anti-mycobacterial agents

(2010) Upasana Singh et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Design, synthesis and biological evaluation of imidazopyridine/pyrimidine-chalcone derivatives as potential anticancer agents

(2010) Ahmed Kamal et al.   MedChemComm

Synthesis and biological evaluation of simple methoxylated chalcones as anticancer, anti-inflammatory and antioxidant agents

(2009) Babasaheb P. Bandgar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-Based Optimization of Benzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B and Low Molecular Weight Protein Tyrosine Phosphatase

(2009) Rosanna Maccari et al.   ChemMedChem

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Solution versus Fluorous versus Solid-Phase Synthesis of 2,5-Disubstituted 1,3-Azoles. Preliminary Antibacterial Activity Studies

(2009) Juan F. Sanz-Cervera et al.   JOURNAL OF ORGANIC CHEMISTRY

Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives

(2008) Zahra Rezaei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bactericidal activity of 2-nitroimidazole against the active replicating stage of Mycobacterium bovis BCG and Mycobacterium tuberculosis with intracellular efficacy in THP-1 macrophages

(2008) Arshad Khan et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Cyclooxygenase-1-Selective Inhibitors Are Attractive Candidates for Analgesics That Do Not Cause Gastric Damage. Design and in Vitro/in Vivo Evaluation of a Benzamide-Type Cyclooxygenase-1 Selective Inhibitor

(2008) Hiroki Kakuta et al.   JOURNAL OF MEDICINAL CHEMISTRY

A simple whole cell based high throughput screening protocol using Mycobacterium bovis BCG for inhibitors against dormant and active tubercle bacilli

(2008) Arshad Khan et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

Inactivation ofLeishmania donovani infantumandTrypanosoma cruziin red cell suspensions with thiazole orange

(2008) Stephen J. Wagner et al.   TRANSFUSION