METTL14 promotes glomerular endothelial cell injury and diabetic nephropathy via m6A modification of α-klotho

N6-methyladenosine METTL3 modulates the proliferation and apoptosis of lens epithelial cells in diabetic cataract

(2020) Jun Yang et al.   Molecular Therapy-Nucleic Acids

Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/PTEN/Akt signaling cascade through DGCR8

(2020) Xu Zha et al.   Aging-US

m6A mRNA Methylation Controls Functional Maturation in Neonatal Murine β Cells

(2020) Yanqiu Wang et al.   DIABETES

N 6 ‐methyladenosine Reader Protein Ythdc2 Suppresses Liver Steatosis via Regulation of mRNA Stability of Lipogenic Genes

(2020) Bing Zhou et al.   HEPATOLOGY

Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells

(2020) Xiaobin Han et al.   HYPERTENSION

Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy

(2020) Sandra Rayego-Mateos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Investigation on urinary and serum alpha klotho in dogs with chronic kidney disease

(2020) Hong jae Yi et al.   BMC Veterinary Research

Whole exome sequencing identifies the novel putative gene variants related with type 2 diabetes in Mizo population, northeast India

(2020) Freda Lalrohlui et al.   GENE

A dynamic reversible RNA N6 -methyladenosine modification: current status and perspectives

(2019) Zhen Bi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

DNA methylation-mediated Klotho silencing is an independent prognostic biomarker of head and neck squamous carcinoma

(2019) Yun Zhu et al.   Cancer Management and Research

MicroRNA-485-5p suppresses the proliferation, migration and invasion of small cell lung cancer cells by targeting flotillin-2

(2019) Feng Gao et al.   Bioengineered

Klotho recovery by genistein via promoter histone acetylation and DNA demethylation mitigates renal fibrosis in mice

(2019) Yanning Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Long noncoding RNA MALAT1 mediates high glucose-induced glomerular endothelial cell injury by epigenetically inhibiting klotho via methyltransferase G9a

(2019) Yebei Li et al.   IUBMB LIFE

Klotho attenuates diabetic nephropathy in db/db mice and ameliorates high glucose-induced injury of human renal glomerular endothelial cells

(2019) Qi Wang et al.   CELL CYCLE

METTL14 is essential for β-cell survival and insulin secretion

(2019) Jun Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Diabetic nephropathy: an insight into molecular mechanisms and emerging therapies

(2019) Annabelle M. Warren et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The N6‐methyladenosine mRNA methylase METTL14 promotes renal ischemic reperfusion injury via suppressing YAP1

(2019) Yao Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The m6A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca2+ influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway

(2019) Dongkui Gong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Urine klotho is a potential early biomarker for acute kidney injury and associated with poor renal outcome after cardiac surgery

(2019) Yingying Qian et al.   BMC Nephrology

Emerging role of m 6 A RNA methylation in nutritional physiology and metabolism

(2019) Jiamin Wu et al.   Obesity Reviews

METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism

(2019) Wei Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Meclofenamic acid promotes cisplatin-induced acute kidney injury by inhibiting fat mass and obesity-associated protein-mediated m6A abrogation in RNA

(2019) Peihui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

METTL14-dependent m6A regulates vascular calcification induced by indoxyl sulfate

(2019) Jing Chen et al.   LIFE SCIENCES

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

(2018) Ying Yang et al.   CELL RESEARCH

Soluble klotho as a marker of renal fibrosis and podocyte injuries in human kidneys

(2018) Nam-Jun Cho et al.   PLoS One

Glucose is involved in the dynamic regulation of m6A in patients with type 2 diabetes

(2018) Ying Yang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Klotho proteins in health and disease

(2018) Makoto Kuro-o   Nature Reviews Nephrology

A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes

(2018) Makiko Taira et al.   PLoS One

Fat Mass and Obesity Associated (FTO) Gene and Hepatic Glucose and Lipid Metabolism

(2018) Tooru Mizuno   Nutrients

Regulatory Role of N6 -methyladenosine (m6 A) Methylation in RNA Processing and Human Diseases

(2017) Wenqiang Wei et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Atrasentan increased the expression of klotho by mediating miR-199b-5p and prevented renal tubular injury in diabetic nephropathy

(2016) Wen-Ling Kang et al.   Scientific Reports

N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5

(2016) Shui Zou et al.   Scientific Reports

DecreasedN6-Methyladenosine in Peripheral Blood RNA From Diabetic Patients Is Associated WithFTOExpression Rather ThanALKBH5

(2015) Fan Shen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Soluble serum Klotho in diabetic nephropathy: Relationship to VEGF-A

(2012) Ina Maria Kacso et al.   CLINICAL BIOCHEMISTRY

Promoter methylation confers kidney-specific expression of the Klotho gene

(2012) Masahiro Azuma et al.   FASEB JOURNAL

High glucose-induced proteome alterations in retinal pigmented epithelium cells and its possible relevance to diabetic retinopathy

(2012) You-Hsuan Chen et al.   Molecular BioSystems