Article
Cell Biology
Jinfeng Zhang, Siyu Hou, Zilong You, Guozheng Li, Shouping Xu, Xianyong Li, Xianyu Zhang, Bo Lei, Da Pang
Summary: The study analyzed the expression and prognostic values of the ARID family in breast cancer, revealing differences in expression levels and outcomes among different molecular subtypes. Some ARID members were associated with favorable outcomes, while others were associated with worse outcomes.
Review
Biochemistry & Molecular Biology
Galateia Liouta, Maria Adamaki, Antonis Tsintarakis, Panagiotis Zoumpourlis, Anastasia Liouta, Sofia Agelaki, Vassilis Zoumpourlis
Summary: Head and neck squamous cell carcinoma (HNSCC) is a term used to describe cancers in the head and neck region. Most cases are diagnosed at a late stage and have poor prognosis. DNA methylation has been identified as a potential biomarker for HNSCC, and this study summarizes the current knowledge on how abnormally methylated DNA profiles may contribute to the development and progression of HNSCC, with the aim of improving management and survival outcomes for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yazan Abu-Shama, Julia Salleron, Florent Carsuzaa, Xu-Shan Sun, Carole Pflumio, Idriss Troussier, Claire Petit, Matthieu Caubet, Arnaud Beddok, Valentin Calugaru, Stephanie Servagi-Vernat, Joel Castelli, Jessica Miroir, Marco Krengli, Paul Giraud, Edouard Romano, Jonathan Khalifa, Melanie Dore, Nicolas Blanchard, Alexandre Coutte, Charles Dupin, Shakeel Sumodhee, Yungan Tao, Vincent Roth, Lionel Geoffrois, Bruno Toussaint, Duc Trung Nguyen, Jean-Christophe Faivre, Juliette Thariat
Summary: A retrospective multicentric study on 322 patients with head and neck cancers of unknown primary (HNCUP) found that neck dissection (ND) improved progression-free survival (PFS) regardless of nodal stage, but did not improve survival rates. The extent of ND did not affect the benefits of the procedure, and the benefits decreased with a more advanced nodal stage.
Article
Oncology
Pablo Nenclares, Lucinda Gunn, Heba Soliman, Mateo Bover, Amy Trinh, Isla Leslie, Kee Howe Wong, Alan Melcher, Kate Newbold, Chris M. Nutting, Derfel Ap Dafydd, Shreerang A. Bhide, Kevin Harrington
Summary: In patients with relapsed and/or metastatic head and neck squamous cell carcinoma (HNSCC) treated with immunotherapy, on-treatment levels of neutrophil-to-lymphocyte ratio (NLR) and fibrinogen are significantly correlated with response and survival outcomes. An on-treatment scoring system incorporating these biomarkers shows appropriate discrimination for predicting overall survival (OS) and progression-free survival (PFS).
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Endocrinology & Metabolism
Zhi-Min Yang, Bing Liao, Si-Si Yang, Tong Su, Jing Zhang, Wei-Ming Wang
Summary: NEK6 is up-regulated in head and neck squamous cell carcinoma (HNSCC) and predicts poor prognosis. It is associated with immune cell infiltration and expression of immune checkpoints, potentially serving as a predictor for prognosis and response to immunotherapy in HNSCC patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Xenia Ray, Whitney Sumner, Leisa Sutton, Parag Sanghvi, Ida Deichaite, Vitali Moiseenko
Summary: This study evaluated if HPV status serves as an independent predictor of dysphagia outcomes for head and neck cancer patients undergoing radiotherapy. The results indicated that cancer type, smoking history, and mean dose were consistently selected as covariates for predicting early dysphagia outcomes. HPV status was seldom selected and oropharyngeal cancer patients were found to have an increased risk of high-grade dysphagia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Virginia Drake, Elaine Bigelow, Carole Fakhry, Melina Windon, Lisa M. Rooper, Patrick Ha, Brett Miles, Christine Gourin, Rajarsi Mandal, Wojciech Mydlarz, Nyall London, Peter S. Vosler, Siddhartha Yavvari, Tanya Troy, Tim Waterboer, David W. Eisele, Gypsyamber D'Souza
Summary: The study revealed that HPV positivity and small tumor size are significant predictors of ER alpha positivity in HNSCC. Male sex, overweight/obesity, and being married/living with a partner may also be associated with ER alpha positivity.
Review
Oncology
Siqi Zhang, Mengge Zheng, Deheng Nie, Lili Xu, Huimin Tian, Mengmeng Wang, Wenjia Liu, Zhenbang Feng, Fujun Han
Summary: The addition of cetuximab to PD-1 inhibitors improves treatment efficacy in patients with HPV-negative HNSCC, but has less benefit in HPV-positive patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Robert Haddad, Tanguy Y. Seiwert, Laura Q. M. Chow, Shilpa Gupta, Jared Weiss, Iris Gluck, Joseph P. Eder, Barbara Burtness, Makoto Tahara, Bhumsuk Keam, Hyunseok Kang, Kei Muro, Andrew Albright, Robin Mogg, Mark Ayers, Lingkang Huang, Jared Lunceford, Razvan Cristescu, Jonathan Cheng, Ranee Mehra
Summary: This study found that tumor mutational burden (TMB), neoantigen load (NL), and T-cell-inflamed gene expression profile (Tcell(inf)GEP) were associated with response, and inflammatory biomarkers (Tcell(inf)GEP and PD-L1) showed a trend towards clinical response. The study also found concordance between HPV status detected by whole exome sequencing (WES) and p16 immunohistochemistry. These findings contribute to predicting response to anti-PD-1 therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Zhongpeng Qiu, Xinhui Du, Kai Chen, Yi Dai, Sibo Wang, Jun Xiao, Gang Li
Summary: The study identified multiple gene signatures related to osteosarcoma and found that these signatures have good prognostic value for predicting patient survival. Functional enrichment analysis showed that key genes related to osteosarcoma are involved in processes such as antigen processing and presentation, phagocytosis, and cell adhesion molecules. These gene signatures could be useful for predicting prognosis and determining subtypes of osteosarcoma.
Review
Oncology
Lukasz Boguszewicz
Summary: This review discusses the molecular biology of head and neck squamous cell carcinomas, focusing on biomarkers for patients' response to induction chemotherapy. The role of induction chemotherapy in treatment is still debated, indicating the need for personalized treatment strategies. A systematic review of available literature identified promising biomarkers but highlighted the need for further studies to confirm their usefulness in personalized medicine.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Chia-Jung Busch, Christian Hagel, Benjamin Becker, Agnes Oetting, Nikolaus Moeckelmann, Conrad Droste, Christina Moeller-Koop, Melanie Witt, Markus Blaurock, Sonja Loges, Kai Rothkamm, Christian Betz, Adrian Muenscher, Till S. Clauditz, Thorsten Rieckmann
Summary: This study investigated the expression of Axl and Gas6 in head and neck squamous cell carcinoma, finding that high expression of Axl indicates a need for adjuvant radiotherapy after surgery. Gas6 expression was found to be a positive predictor of survival in patients receiving radiotherapy.
Article
Genetics & Heredity
Wen Gao, Zhe-Wen Zhang, Hong-Yi Wang, Xin-Di Li, Wei-Ting Peng, Hao-Yu Guan, Yu-Xuan Liao, An Liu
Summary: The study found that TMED2/9/10 and related genes may jointly affect the prognosis of HNSC, providing specific clues for further experimental research, personalized diagnosis strategies, and targeted clinical therapy for HNSC.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Yuchen Liu, Zhechen Wu, Ziyue Fu, Yanxun Han, Jianpeng Wang, Yanqiang Zhang, Bingyu Liang, Ye Tao, Yuchen Zhang, Chuanlu Shen, Yidan Xu, Siyue Yin, Bangjie Chen, Yehai Liu, Haifeng Pan, Zhang Liang, Kaile Wu
Summary: This study investigated focal adhesion-related genes (FARGs) in head and neck squamous cell carcinoma (HNSCC) and identified two molecular subtypes. A FARG signature model consisting of 9 genes was developed and proven to be a reliable prognostic predictor for HNSCC patients. Furthermore, FARGs were found to be associated with immune infiltration, gene mutation status, and chemosensitivity, providing potential targets for targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Ana Carolina da Silva Lima, Tathiany Jessica Ferreira, Adriana Divina de Souza Campos, Larissa Morinaga Matida, Maria Beatriz Trindade Castro, Ana Amelia Freitas-Vilela, Maria Aderuza Horst
Summary: Most patients with head and neck squamous cell carcinoma are diagnosed in the advanced stages. This study investigated the association between dietary patterns and tumor staging and cell differentiation in newly diagnosed patients with HNSCC. The results showed that a higher adherence to a processed food dietary pattern was associated with advanced tumor staging. This finding contributes to the development of nutritional guidance for reducing the risk of HNSCC.