Klotho attenuates diabetic nephropathy in db/db mice and ameliorates high glucose-induced injury of human renal glomerular endothelial cells

Soluble klotho as a marker of renal fibrosis and podocyte injuries in human kidneys

(2018) Nam-Jun Cho et al.   PLoS One

PNMA1, regulated by miR-33a-5p, promotes proliferation and EMT in hepatocellular carcinoma by activating the Wnt/β-catenin pathway

(2018) Pengpeng Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Allopurinol protects human glomerular endothelial cells from high glucose-induced reactive oxygen species generation, p53 overexpression and endothelial dysfunction

(2017) Theodoros Eleftheriadis et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Dual inhibition of renin-angiotensin-aldosterone system and endothelin-1 in treatment of chronic kidney disease

(2016) Radko Komers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Role of Renin Angiotensin Aldosterone System Genes in Diabetic Nephropathy

(2016) Zohreh Rahimi   Canadian Journal of Diabetes

Activation of general control nonderepressible 2 kinase protects human glomerular endothelial cells from harmful high-glucose-induced molecular pathways

(2016) Theodoros Eleftheriadis et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients

(2016) Sang Soo Kim et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression

(2016) Taisuke Irifuku et al.   KIDNEY INTERNATIONAL

Atrasentan increased the expression of klotho by mediating miR-199b-5p and prevented renal tubular injury in diabetic nephropathy

(2016) Wen-Ling Kang et al.   Scientific Reports

Klotho attenuates renal hypertrophy and glomerular injury in Ins2Akita diabetic mice

(2015) Hiroyuki Kadoya et al.   Clinical and Experimental Nephrology

Adipose-Derived Mesenchymal Stem Cells Transplantation Alleviates Renal Injury in Streptozotocin-Induced Diabetic Nephropathy

(2015) Weimin Ni et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Klotho: a tumor suppressor and modulator of the Wnt/β-catenin pathway in human hepatocellular carcinoma

(2015) Xiaowei Tang et al.   LABORATORY INVESTIGATION

Klotho gene delivery ameliorates renal hypertrophy and fibrosis in streptozotocin-induced diabetic rats by suppressing the Rho-associated coiled-coil kinase signaling pathway

(2015) MINGHONG DENG et al.   Molecular Medicine Reports

Multiple Genes of the Renin-Angiotensin System Are Novel Targets of Wnt/ -Catenin Signaling

(2014) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genetic Deficiency of Anti-Aging GeneKlothoExacerbates Early Nephropathy in STZ-Induced Diabetes in Male Mice

(2013) Yi Lin et al.   ENDOCRINOLOGY

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

(2013) Jie Yang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/ -Catenin Signaling

(2013) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Glimpse of the Pathogenetic Mechanisms of Wnt/β-Catenin Signaling in Diabetic Nephropathy

(2013) Li Xiao et al.   Biomed Research International

Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis

(2012) Yoshiko Shimamura et al.   Clinical and Experimental Nephrology

Klotho in health and disease

(2012) Makoto Kuro-o   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion

(2012) Osamu Asai et al.   KIDNEY INTERNATIONAL

Klotho as a potential biomarker and therapy for acute kidney injury

(2012) Ming-Chang Hu et al.   Nature Reviews Nephrology

Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy

(2011) T. Zhou et al.   DIABETOLOGIA

Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

(2011) Shigehiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockade of Wnt/ -Catenin Signaling by Paricalcitol Ameliorates Proteinuria and Kidney Injury

(2010) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

(2008) I Wolf et al.   ONCOGENE