Kynurenic acid protects against mastitis in mice by ameliorating inflammatory responses and enhancing blood-milk barrier integrity

The gut microbiota contributes to the development of Staphylococcus aureus-induced mastitis in mice

(2020) Xiaoyu Hu et al.   ISME Journal

Functional Metabolomics Reveal the Role of AHR/GPR35 Mediated Kynurenic acid Gradient Sensing in Chemotherapy-induced Intestinal Damage

(2020) Di Wang et al.   Acta Pharmaceutica Sinica B

Vanillin protects the blood–milk barrier and inhibits the inflammatory response in LPS-induced mastitis in mice

(2019) Wenjin Guo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Kynurenic acid/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress

(2019) Xiao Zheng et al.   BRAIN BEHAVIOR AND IMMUNITY

Targeting gut microbiota as a possible therapy for mastitis

(2019) Xiaoyu Hu et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Emerging roles of bile acids in mucosal immunity and inflammation

(2019) Mei Lan Chen et al.   Mucosal Immunology

A Protective Role of the NRF2-Keap1 Pathway in Maintaining Intestinal Barrier Function

(2019) Zhiyong Wen et al.   Oxidative Medicine and Cellular Longevity

Allicin Inhibited Staphylococcus aureus -Induced Mastitis by Reducing Lipid Raft Stability via LxRα in Mice

(2019) Yu Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dimethyl itaconate protects against lippolysacchride-induced mastitis in mice by activating MAPKs and Nrf2 and inhibiting NF-κB signaling pathways

(2019) Caijun Zhao et al.   MICROBIAL PATHOGENESIS

Kynurenic acid attenuates pro-inflammatory reactions in lipopolysaccharide-stimulated endothelial cells through the PPARδ/HO-1-dependent pathway

(2019) Taeseung Lee et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Cell-Specific Imd-NF-κB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection

(2018) Zongzhao Zhai et al.   IMMUNITY

Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis

(2018) M Anthony Sofia et al.   INFLAMMATORY BOWEL DISEASES

IL-1β induces increased tight junction permeability in bovine mammary epithelial cells via the IL-1β-ERK1/2-MLCK axis upon blood-milk barrier damage

(2018) Tong Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Kynurenic acid and its derivatives are able to modulate the adhesion and locomotion of brain endothelial cells

(2018) Eszter Lajkó et al.   JOURNAL OF NEURAL TRANSMISSION

Kynurenic Acid Restores Nrf2 Levels and Prevents Quinolinic Acid-Induced Toxicity in Rat Striatal Slices

(2018) Fernanda Silva Ferreira et al.   MOLECULAR NEUROBIOLOGY

Aryl hydrocarbon receptor and intestinal immunity

(2018) Bruno Lamas et al.   Mucosal Immunology

Influence of intrauterine administration of Lactobacillus buchneri on reproductive performance and pro-inflammatory endometrial mRNA expression of cows with subclinical endometritis

(2018) S. Peter et al.   Scientific Reports

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

(2018) Jing Gao et al.   Frontiers in Cellular and Infection Microbiology

Kynurenic Acid: The Janus-Faced Role of an Immunomodulatory Tryptophan Metabolite and Its Link to Pathological Conditions

(2018) Elisa Wirthgen et al.   Frontiers in Immunology

Tryptophan, kynurenine, kynurenic acid concentrations and indoleamine 2,3-dioxygenase activity in serum and milk of dairy cows with subclinical mastitis caused by coagulase-negative staphylococci

(2018) Mariola Bochniarz et al.   REPRODUCTION IN DOMESTIC ANIMALS

A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor

(2018) Jinlei Yu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Aryl Hydrocarbon Receptor: Connecting Immunity to the Microenvironment

(2018) Rahul Shinde et al.   TRENDS IN IMMUNOLOGY

Assessment of risk factors and isolation of Staphylococcus aureus and Escherichia coli from bovine subclinical mastitic milk in and around Gondar, Northwest Ethiopia

(2018) Amare Bihon et al.   TROPICAL ANIMAL HEALTH AND PRODUCTION

Melatonin and derived l -tryptophan metabolites produced during alcoholic fermentation by different wine yeast strains

(2017) E. Fernández-Cruz et al.   FOOD CHEMISTRY

Differentiating Staphylococcus aureus from Escherichia coli mastitis: S. aureus triggers unbalanced immune-dampening and host cell invasion immediately after udder infection

(2017) Juliane Günther et al.   Scientific Reports

Propionate Protects against Lipopolysaccharide-Induced Mastitis in Mice by Restoring Blood–Milk Barrier Disruption and Suppressing Inflammatory Response

(2017) Jingjing Wang et al.   Frontiers in Immunology

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Short communication: Differential loss of bovine mammary epithelial barrier integrity in response to lipopolysaccharide and lipoteichoic acid

(2016) Olga Wellnitz et al.   JOURNAL OF DAIRY SCIENCE

Polymorphism of Kynurenine Pathway-Related Genes, Kynurenic Acid, and Psychopathological Symptoms in HIV

(2016) Vanessa Douet et al.   Journal of Neuroimmune Pharmacology

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

(2015) Francis Ka-Ming Chan et al.   Annual Review of Immunology

TRAM-Derived Decoy Peptides inhibits the inflammatory response in mouse mammary epithelial cells and a mastitis model in mice

(2015) Xiaoyu Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Increased Plasma Levels of Xanthurenic and Kynurenic Acids in Type 2 Diabetes

(2015) Gregory F. Oxenkrug   MOLECULAR NEUROBIOLOGY

G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease

(2015) Nina Divorty et al.   Frontiers in Pharmacology

The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice

(2013) Chunfen Mo et al.   ANTIOXIDANTS & REDOX SIGNALING

Increased T-Helper 2 Cytokines in Bile From Patients With IgG4-Related Cholangitis Disrupt the Tight Junction–Associated Biliary Epithelial Cell Barrier

(2013) Tobias Müller et al.   GASTROENTEROLOGY

The Role of Tight Junctions in Mammary Gland Function

(2013) Kerst Stelwagen et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Lipopolysaccharide Disrupts the Milk-Blood Barrier by Modulating Claudins in Mammary Alveolar Tight Junctions

(2013) Ken Kobayashi et al.   PLoS One

Kynurenic Acid in Plasma and Endometrium in Bitches with Pyometra

(2012) Roman Dąbrowski et al.   INFLAMMATION

TNF signaling drives myeloid-derived suppressor cell accumulation

(2012) Xueqiang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin receptor activates a MYD88–ARNO–ARF6 cascade to disrupt vascular stability

(2012) Weiquan Zhu et al.   NATURE

Antimicrobial Resistance of Mastitis Pathogens

(2012) Stephen P. Oliver et al.   VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE

Mastitis and its Impact on Structure and Function in the Ruminant Mammary Gland

(2011) R. Michael Akers et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

Orthologue selectivity and ligand bias: translating the pharmacology of GPR35

(2011) Graeme Milligan   TRENDS IN PHARMACOLOGICAL SCIENCES

Psychological Stress-Induced, IDO1-Dependent Tryptophan Catabolism: Implications on Immunosuppression in Mice and Humans

(2010) Cornelia Kiank et al.   PLoS One

Milk yield and associated economic losses in quarters with subclinical mastitis due to Staphylococcus aureus in Ethiopian crossbred dairy cows

(2009) Gebreyohannes Y. Tesfaye et al.   TROPICAL ANIMAL HEALTH AND PRODUCTION