Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation

Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome

(2020) Evan J Worden et al.   eLife

Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome

(2020) Felix R. Wagner et al.   NATURE

S-phase-independent silencing establishment in Saccharomyces cerevisiae

(2020) Davis Goodnight et al.   eLife

Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase

(2019) Cathy J. Anderson et al.   Cell Reports

Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase

(2019) Seongmin Jang et al.   GENES & DEVELOPMENT

Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome

(2019) Tonghui Yao et al.   CELL RESEARCH

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L

(2019) Evan J. Worden et al.   CELL

Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination

(2019) Marco Igor Valencia-Sánchez et al.   MOLECULAR CELL

Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L‐dose dependency in HDAC1‐deficient thymic lymphoma

(2019) Hanneke Vlaming et al.   EMBO JOURNAL

Structure and function of the Orc1 BAH-nucleosome complex

(2019) Pablo De Ioannes et al.   Nature Communications

Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome

(2019) Jean Paul Armache et al.   eLife

Structural basis of nucleosome recognition and modification by MLL methyltransferases

(2019) Han Xue et al.   NATURE

Activation and regulation of H2B-Ubiquitin-dependent histone methyltransferases

(2019) Evan J Worden et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast

(2018) Soyun Lee et al.   Nature Communications

cisTEM, user-friendly software for single-particle image processing

(2018) Timothy Grant et al.   eLife

Structural basis for ATP-dependent chromatin remodelling by the INO80 complex

(2018) Sebastian Eustermann et al.   NATURE

Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism

(2018) Tibor van Welsem et al.   NUCLEIC ACIDS RESEARCH

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Nucleosome–Chd1 structure and implications for chromatin remodelling

(2017) Lucas Farnung et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Measuring the effects of particle orientation to improve the efficiency of electron cryomicroscopy

(2017) Katerina Naydenova et al.   Nature Communications

Recognition of the nucleosome by chromatin factors and enzymes

(2016) Robert K McGinty et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3

(2016) Hariharan Jayaram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Modifications and Cancer

(2016) James E. Audia et al.   Cold Spring Harbor Perspectives in Biology

Heterochromatin assembly by interrupted Sir3 bridges across neighboring nucleosomes

(2016) Reza Behrouzi et al.   eLife

Genetically Encoding Lysine Modifications on Histone H4

(2015) Bryan J. Wilkins et al.   ACS Chemical Biology

Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond

(2015) Chun-Wei Chen et al.   EXPERIMENTAL HEMATOLOGY

Contributions of pocket depth and electrostatic interactions to affinity and selectivity of receptors for methylated lysine in water

(2015) Joshua E. Beaver et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins

(2015) Jos J.A.G. Kamps et al.   Nature Communications

Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties

(2015) Iris J. E. Stulemeijer et al.   Scientific Reports

Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation

(2015) Masatoshi Wakamori et al.   Scientific Reports

The emerging roles of DOT1L in leukemia and normal development

(2014) C M McLean et al.   LEUKEMIA

Generation of nonhydrolyzable ubiquitin–histone mimics

(2014) Lindsey Long et al.   METHODS

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

(2013) Xueming Li et al.   NATURE METHODS

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

(2013) P. W. Lewis et al.   SCIENCE

Epigenetics in Saccharomyces cerevisiae

(2013) M. Grunstein et al.   Cold Spring Harbor Perspectives in Biology

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

(2011) Kathrin M. Bernt et al.   CANCER CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

A dual role of H4K16 acetylation in the establishment of yeast silent chromatin

(2011) Mariano Oppikofer et al.   EMBO JOURNAL

Dot1 and Histone H3K79 Methylation in Natural Telomeric and HM Silencing

(2011) Yoh-Hei Takahashi et al.   MOLECULAR CELL

A Common Telomeric Gene Silencing Assay Is Affected by Nucleotide Metabolism

(2011) Marlies P. Rossmann et al.   MOLECULAR CELL

Structural Basis of Silencing: Sir3 BAH Domain in Complex with a Nucleosome at 3.0 A Resolution

(2011) K.-J. Armache et al.   SCIENCE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Language of Histone Crosstalk

(2010) Jung-Shin Lee et al.   CELL

Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1

(2009) Shima Nakanishi et al.   JOURNAL OF CELL BIOLOGY

Reconstitution of Yeast Silent Chromatin: Multiple Contact Sites and O-AADPR Binding Load SIR Complexes onto Nucleosomes In Vitro

(2009) Fabrizio Martino et al.   MOLECULAR CELL

The establishment of gene silencing at single-cell resolution

(2009) Erin A Osborne et al.   NATURE GENETICS

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL

Crosstalk among Histone Modifications

(2008) Tamaki Suganuma et al.   CELL

DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

(2008) D. J. Steger et al.   MOLECULAR AND CELLULAR BIOLOGY

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

(2008) Robert K. McGinty et al.   NATURE

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS

Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states

(2008) Floor Frederiks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

(2008) Brendan Jones et al.   PLoS Genetics