The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication

Advances in understanding DNA processing and protection at stalled replication forks

(2019) Kimberly Rickman et al.   JOURNAL OF CELL BIOLOGY

H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids

(2019) Kyosuke Nakamura et al.   NATURE CELL BIOLOGY

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation

(2019) Dali Zong et al.   MOLECULAR CELL

The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination

(2019) Weixing Zhao et al.   Annual Review of Biochemistry

Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance

(2019) Eliana MC Tacconi et al.   EMBO Molecular Medicine

BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling

(2019) Sachin Verma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BARD1 is A Low/Moderate Breast Cancer Risk Gene: Evidence Based on An Association Study of the Central European p.Q564X Recurrent Mutation

(2019) Suszynska et al.   Cancers

Replication-Coupled DNA Repair

(2019) David Cortez   MOLECULAR CELL

Isomerization of BRCA1–BARD1 promotes replication fork protection

(2019) Manuel Daza-Martin et al.   NATURE

DNA double-strand break repair-pathway choice in somatic mammalian cells

(2019) Ralph Scully et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection

(2019) Nicole L Batenburg et al.   NUCLEIC ACIDS RESEARCH

RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer

(2018) C Cruz et al.   ANNALS OF ONCOLOGY

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

(2018) Ewa Gogola et al.   CANCER CELL

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

(2018) Rajat Gupta et al.   CELL

FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1‐defective cells

(2018) Junya Tomida et al.   EMBO JOURNAL

Emerging roles of CST in maintaining genome stability and human disease

(2018) Jason A Stewart   Frontiers in Bioscience-Landmark

How cells ensure correct repair of DNA double-strand breaks

(2018) Joonyoung Her et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer

(2018) Quan Zhu et al.   MOLECULAR CELL

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells

(2018) Harveer Dev et al.   NATURE CELL BIOLOGY

Synthetic lethal therapies for cancer: what’s next after PARP inhibitors?

(2018) Alan Ashworth et al.   Nature Reviews Clinical Oncology

BARD1 is necessary for ubiquitylation of nucleosomal histone H2A and for transcriptional regulation of estrogen metabolism genes

(2018) Mikaela D. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

(2018) Sarah Cohen et al.   Nature Communications

Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48

(2018) Georgia Velimezi et al.   Nature Communications

USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A

(2018) Michael Uckelmann et al.   Nature Communications

Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

(2018) Jone Michelena et al.   Nature Communications

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells

(2018) Marco Barazas et al.   Cell Reports

DNA double-strand breaks as drivers of neural genomic change, function, and disease

(2018) Frederick W. Alt et al.   DNA REPAIR

Mechanisms of PARP inhibitor sensitivity and resistance

(2018) Alan D. D’Andrea   DNA REPAIR

Preserving replication fork integrity and competence via the homologous recombination pathway

(2018) Anissia Ait Saada et al.   DNA REPAIR

Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells

(2018) Natalie Saini et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection

(2018) David Billing et al.   MOLECULAR CELL

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

(2018) Michal Zimmermann et al.   NATURE

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

(2018) Hind Ghezraoui et al.   NATURE

The shieldin complex mediates 53BP1-dependent DNA repair

(2018) Sylvie M. Noordermeer et al.   NATURE

53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in

(2018) Zachary Mirman et al.   NATURE

Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation

(2018) Jennifer K. Litton et al.   NEW ENGLAND JOURNAL OF MEDICINE

BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

(2018) Joseph Nacson et al.   Cell Reports

Radiosensitivity is an acquired vulnerability of PARPi-resistant BRCA1-deficient tumors

(2018) Marco Barazas et al.   CANCER RESEARCH

A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation

(2018) Marta Castroviejo‐Bermejo et al.   EMBO Molecular Medicine

CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

(2018) Sara Przetocka et al.   MOLECULAR CELL

DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells

(2018) Yizhou Joseph He et al.   NATURE

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

(2018) Jordan R. Becker et al.   Nature Communications

Directing the use of DDR kinase inhibitors in cancer treatment

(2017) Inger Brandsma et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Genome integrity and disease prevention in the nervous system

(2017) Peter J. McKinnon   GENES & DEVELOPMENT

Transcription-Coupled DNA Double-Strand Break Repair: Active Genes Need Special Care

(2017) Aline Marnef et al.   JOURNAL OF MOLECULAR BIOLOGY

Senataxin: Genome Guardian at the Interface of Transcription and Neurodegeneration

(2017) Matthias Groh et al.   JOURNAL OF MOLECULAR BIOLOGY

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial

(2017) Elizabeth M Swisher et al.   LANCET ONCOLOGY

Modeling Therapy Resistance in BRCA1/2 -Mutant Cancers

(2017) Amy Dréan et al.   MOLECULAR CANCER THERAPEUTICS

Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers

(2017) Angelo Taglialatela et al.   MOLECULAR CELL

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

(2017) Arun Mouli Kolinjivadi et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

(2017) Weixing Zhao et al.   NATURE

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells

(2017) Hervé Técher et al.   NATURE REVIEWS GENETICS

Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation

(2017) Mark Robson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms

(2017) Mikaela D. Stewart et al.   PROTEIN SCIENCE

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

(2017) Hong Xu et al.   Nature Communications

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

(2017) Delphine Lemaçon et al.   Nature Communications

The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate

(2017) Beom-Jun Kim et al.   Cell Reports

The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair

(2017) Ruth M. Densham et al.   Nucleus

Dualistic Role of BARD1 in Cancer

(2017) Flora Cimmino et al.   Genes

The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair

(2017) Ruth M. Densham et al.   Nucleus

BARD1 Gene Polymorphisms Confer Nephroblastoma Susceptibility

(2017) Wen Fu et al.   EBioMedicine

Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

(2016) Corina Ohle et al.   CELL

Conflict Resolution in the Genome: How Transcription and Replication Make It Work

(2016) Stephan Hamperl et al.   CELL

Mechanism and regulation of DNA end resection in eukaryotes

(2016) Lorraine S. Symington   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity

(2016) Johanna Michl et al.   EMBO JOURNAL

53BP1 ablation rescues genomic instability in mice expressing ‘RING‐less’ BRCA1

(2016) Minxing Li et al.   EMBO REPORTS

Noncanonical views of homology-directed DNA repair

(2016) Priyanka Verma et al.   GENES & DEVELOPMENT

RING domain–deficient BRCA1 promotes PARP inhibitor and platinum resistance

(2016) Yifan Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

(2016) Rinske Drost et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer

(2016) Petra ter Brugge et al.   JNCI-Journal of the National Cancer Institute

DEAD Box 1 Facilitates Removal of RNA and Homologous Recombination at DNA Double-Strand Breaks

(2016) Lei Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

(2016) Jutta Zimmer et al.   MOLECULAR CELL

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

The structural basis of modified nucleosome recognition by 53BP1

(2016) Marcus D. Wilson et al.   NATURE

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer

(2016) Mansoor R. Mirza et al.   NEW ENGLAND JOURNAL OF MEDICINE

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

(2016) Y. Pommier et al.   Science Translational Medicine

Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development

(2016) Sreejith J. Nair et al.   Nature Communications

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer

(2016) Petra ter Brugge et al.   JNCI-Journal of the National Cancer Institute

Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage

(2015) W. Wu et al.   CANCER RESEARCH

Biochemical mechanism of DSB end resection and its regulation

(2015) James M. Daley et al.   DNA REPAIR

DNA2 drives processing and restart of reversed replication forks in human cells

(2015) Saravanabhavan Thangavel et al.   JOURNAL OF CELL BIOLOGY

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks

(2015) Martin R. Higgs et al.   MOLECULAR CELL

A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination

(2015) Anderson T. Wang et al.   MOLECULAR CELL

Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry

(2015) Weixing Zhao et al.   MOLECULAR CELL

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

(2015) Elodie Hatchi et al.   MOLECULAR CELL

A mechanism for the suppression of homologous recombination in G1 cells

(2015) Alexandre Orthwein et al.   NATURE

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

(2015) Guotai Xu et al.   NATURE

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

(2015) Joaquin Mateo et al.   NEW ENGLAND JOURNAL OF MEDICINE

SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells

(2015) Meryem Alagoz et al.   NUCLEIC ACIDS RESEARCH

Breaking bad: R-loops and genome integrity

(2015) Julie Sollier et al.   TRENDS IN CELL BIOLOGY

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer

(2015) P. A. Konstantinopoulos et al.   Cancer Discovery

Cancers associated withBRCA1andBRCA2mutations other than breast and ovarian

(2014) Jacqueline Mersch et al.   CANCER

Holliday junction resolution: Regulation in space and time

(2014) Joao Matos et al.   DNA REPAIR

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage

(2014) Sarah J. Hill et al.   GENES & DEVELOPMENT

PTIP associates with Artemis to dictate DNA repair pathway choice

(2014) Jiadong Wang et al.   GENES & DEVELOPMENT

Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer

(2014) Clara Esteban-Jurado et al.   GENETICS IN MEDICINE

CtIP-mediated resection is essential for viability and can operate independently of BRCA1

(2014) Federica Polato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial

(2014) Jonathan Ledermann et al.   LANCET ONCOLOGY

BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle

(2014) Anthony J. Davis et al.   NUCLEIC ACIDS RESEARCH

DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal

(2014) Sébastien Britton et al.   NUCLEIC ACIDS RESEARCH

Mediators of Homologous DNA Pairing

(2014) A. Zelensky et al.   Cold Spring Harbor Perspectives in Biology

BRCA1 haploinsufficiency for replication stress suppression in primary cells

(2014) Shailja Pathania et al.   Nature Communications

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

(2014) Nozomi Tomimatsu et al.   Nature Communications

Biallelic Mutations in BRCA1 Cause a New Fanconi Anemia Subtype

(2014) Sarah L. Sawyer et al.   Cancer Discovery

BRCA1 Is a Histone-H2A-Specific Ubiquitin Ligase

(2014) Reinhard Kalb et al.   Cell Reports

BRCA1 Accelerates CtIP-Mediated DNA-End Resection

(2014) Andrés Cruz-García et al.   Cell Reports

Function of BRCA1 in the DNA Damage Response Is Mediated by ADP-Ribosylation

(2013) Mo Li et al.   CANCER CELL

53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions

(2013) Elsa Callen et al.   CELL

Efficacy of Chemotherapy in BRCA1/2 Mutation Carrier Ovarian Cancer in the Setting of PARP Inhibitor Resistance: A Multi-Institutional Study

(2013) J. E. Ang et al.   CLINICAL CANCER RESEARCH

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases

(2013) Julio Morales et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression

(2013) Colleen R. Reczek et al.   JOURNAL OF CELL BIOLOGY

Genomes and G-Quadruplexes: For Better or for Worse

(2013) Madalena Tarsounas et al.   JOURNAL OF MOLECULAR BIOLOGY

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

The BRCA1/BARD1-Interacting Protein OLA1 Functions in Centrosome Regulation

(2013) Ayako Matsuzawa et al.   MOLECULAR CELL

Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection

(2013) Andreas Kakarougkas et al.   NUCLEIC ACIDS RESEARCH

Role of 53BP1 oligomerization in regulating double-strand break repair

(2013) F. Lottersberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair

(2013) C. Clauson et al.   Cold Spring Harbor Perspectives in Biology

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Common Variation at BARD1 Results in the Expression of an Oncogenic Isoform That Influences Neuroblastoma Susceptibility and Oncogenicity

(2012) K. R. Bosse et al.   CANCER RESEARCH

A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair

(2012) Ko Sato et al.   CURRENT BIOLOGY

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway

(2012) H. Kim et al.   GENES & DEVELOPMENT

Associations betweenBRCAMutations in High-Risk Breast Cancer Patients and Familial Cancers Other than Breast or Ovary

(2012) Jae Myoung Noh et al.   Journal of Breast Cancer

BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

(2012) J. R. Chapman et al.   JOURNAL OF CELL SCIENCE

BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair

(2012) Samuel F. Bunting et al.   MOLECULAR CELL

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection

(2012) Thomas Costelloe et al.   NATURE

The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends

(2012) Xuefeng Chen et al.   NATURE

Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents

(2012) G. Zoppoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1 -Mutated Mouse Mammary Tumors

(2012) Janneke E. Jaspers et al.   Cancer Discovery

Biallelic Deleterious BRCA1 Mutations in a Woman with Early-Onset Ovarian Cancer

(2012) Susan M. Domchek et al.   Cancer Discovery

BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance

(2011) Rinske Drost et al.   CANCER CELL

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Secondary Somatic Mutations Restoring BRCA1/2 Predict Chemotherapy Resistance in Hereditary Ovarian Carcinomas

(2011) Barbara Norquist et al.   JOURNAL OF CLINICAL ONCOLOGY

KIAA0101 Interacts with BRCA1 and Regulates Centrosome Number

(2011) Z. Kais et al.   MOLECULAR CANCER RESEARCH

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

(2011) Quan Zhu et al.   NATURE

RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks

(2011) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity

(2011) R. Shakya et al.   SCIENCE

BRD7, a Subunit of SWI/SNF Complexes, Binds Directly to BRCA1 and Regulates BRCA1-Dependent Transcription

(2010) M. T. Harte et al.   CANCER RESEARCH

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Cancer predisposing missense and protein truncatingBARD1mutations in non-BRCA1orBRCA2breast cancer families

(2010) Sylvia De Brakeleer et al.   HUMAN MUTATION

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

(2009) Feng Zhang et al.   CURRENT BIOLOGY

A Selective Requirement for 53BP1 in the Biological Response to Genomic Instability Induced by Brca1 Deficiency

(2009) Liu Cao et al.   MOLECULAR CELL

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

(2009) S. M. H. Sy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Advances in Chemical Carcinogenesis: A Historical Review and Prospective

(2008) L. A. Loeb et al.   CANCER RESEARCH

Secondary BRCA1 Mutations in BRCA1-Mutated Ovarian Carcinomas with Platinum Resistance

(2008) E. M. Swisher et al.   CANCER RESEARCH

The Fanconi anaemia/BRCA pathway and cancer susceptibility. Searching for new therapeutic targets

(2008) M. José García et al.   Clinical & Translational Oncology

Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

(2008) Longchuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks

(2008) O. Zgheib et al.   MOLECULAR AND CELLULAR BIOLOGY

CDK targets Sae2 to control DNA-end resection and homologous recombination

(2008) Pablo Huertas et al.   NATURE

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression

(2008) R. Shakya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

(2008) L. J. Reid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

(2008) S. Rottenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA