FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner

Single-molecule tracking of transcription protein dynamics in living cells: seeing is believing, but what are we seeing?

(2021) Timothée Lionnet et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Structural basis of nucleosome transcription mediated by Chd1 and FACT

(2021) Lucas Farnung et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spatiotemporal coordination of transcription preinitiation complex assembly in live cells

(2021) Vu Q. Nguyen et al.   MOLECULAR CELL

Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin

(2021) Jee Min Kim et al.   eLife

Live-cell single particle imaging reveals the role of RNA polymerase II in histone H2A.Z eviction

(2020) Anand Ranjan et al.   eLife

The role of FACT in managing chromatin: disruption, assembly, or repair?

(2020) Tim Formosa et al.   NUCLEIC ACIDS RESEARCH

RNA Polymerase II CTD Tyrosine 1 Is Required for Efficient Termination by the Nrd1-Nab3-Sen1 Pathway

(2019) Pierre Collin et al.   MOLECULAR CELL

Structural insight into nucleosome transcription by RNA polymerase II with elongation factors

(2019) Haruhiko Ehara et al.   SCIENCE

A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing

(2019) Theophilus T. Tettey et al.   Cell Reports

Histone Recycling by FACT and Spt6 during Transcription Prevents the Scrambling of Histone Modifications

(2019) Célia Jeronimo et al.   Cell Reports

Rational Design of Fluorogenic and Spontaneously Blinking Labels for Super-Resolution Imaging

(2019) Qinsi Zheng et al.   ACS Central Science

FACT caught in the act of manipulating the nucleosome

(2019) Yang Liu et al.   NATURE

The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions

(2019) Magdalena Murawska et al.   MOLECULAR CELL

Role of Chromatin Damage and Chromatin Trapping of FACT in Mediating the Anticancer Cytotoxicity of DNA-Binding Small-Molecule Drugs

(2018) Elimelech Nesher et al.   CANCER RESEARCH

Acetylation-Dependent Recruitment of the FACT Complex and Its Role in Regulating Pol II Occupancy Genome-Wide inSaccharomyces cerevisiae

(2018) Rakesh Pathak et al.   GENETICS

Widespread and precise reprogramming of yeast protein–genome interactions in response to heat shock

(2018) Vinesh Vinayachandran et al.   GENOME RESEARCH

Functional roles of the DNA-binding HMGB domain in the histone chaperone FACT in nucleosome reorganization

(2018) Laura L. McCullough et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simplified ChIP-exo assays

(2018) Matthew J. Rossi et al.   Nature Communications

Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation

(2018) Roubina Tatavosian et al.   Nature Communications

Robust model-based analysis of single-particle tracking experiments with Spot-On

(2018) Anders S Hansen et al.   eLife

Acetylation-Dependent Recruitment of the FACT Complex and Its Role in Regulating Pol II Occupancy Genome-Wide inSaccharomyces cerevisiae

(2018) Rakesh Pathak et al.   GENETICS

Unification of Protein Abundance Datasets Yields a Quantitative Saccharomyces cerevisiae Proteome

(2018) Brandon Ho et al.   Cell Systems

Structure and function of the histone chaperone FACT – Resolving FACTual issues

(2018) Katerina Gurova et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Structural basis of the nucleosome transition during RNA polymerase II passage

(2018) Tomoya Kujirai et al.   SCIENCE

Structure of transcribing RNA polymerase II-nucleosome complex

(2018) Lucas Farnung et al.   Nature Communications

An mRNA Capping Enzyme Targets FACT to the Active Gene To Enhance the Engagement of RNA Polymerase II into Transcriptional Elongation

(2017) Rwik Sen et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcription and Remodeling Produce Asymmetrically Unwrapped Nucleosomal Intermediates

(2017) Srinivas Ramachandran et al.   MOLECULAR CELL

Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation

(2017) Ameet Shetty et al.   MOLECULAR CELL

Nucleosome–Chd1 structure and implications for chromatin remodelling

(2017) Lucas Farnung et al.   NATURE

Understanding nucleosome dynamics and their links to gene expression and DNA replication

(2017) William K. M. Lai et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The elongation factor Spt4/5 regulates RNA polymerase II transcription through the nucleosome

(2017) John B. Crickard et al.   NUCLEIC ACIDS RESEARCH

OUP accepted manuscript

(2017)   NUCLEIC ACIDS RESEARCH

Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity

(2017) Alessia Loffreda et al.   Nature Communications

A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription

(2017) Matthew A Sdano et al.   eLife

CTCF and cohesin regulate chromatin loop stability with distinct dynamics

(2017) Anders S Hansen et al.   eLife

Integrated molecular mechanism directing nucleosome reorganization by human FACT

(2016) Yasuo Tsunaka et al.   GENES & DEVELOPMENT

A Comprehensive Toolbox for Genome Editing in Cultured Drosophila melanogaster Cells

(2016) Stefan Kunzelmann et al.   G3-Genes Genomes Genetics

The Abundant Histone Chaperones Spt6 and FACT Collaborate to Assemble, Inspect, and Maintain Chromatin Structure in Saccharomyces cerevisiae

(2015) L. McCullough et al.   GENETICS

The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations

(2015) Célia Jeronimo et al.   MOLECULAR CELL

Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq

(2015) Gilad Fuchs et al.   Nature Protocols

Histone exchange, chromatin structure and the regulation of transcription

(2015) Swaminathan Venkatesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New vectors for simple and streamlined CRISPR-Cas9 genome editing inSaccharomyces cerevisiae

(2015) Marian F. Laughery et al.   YEAST

Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells

(2014) Jiji Chen et al.   CELL

TFIIH Phosphorylation of the Pol II CTD Stimulates Mediator Dissociation from the Preinitiation Complex and Promoter Escape

(2014) Koon Ho Wong et al.   MOLECULAR CELL

Kin28 regulates the transient association of Mediator with core promoters

(2014) Célia Jeronimo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

VAP: a versatile aggregate profiler for efficient genome-wide data representation and discovery

(2014) C. Coulombe et al.   NUCLEIC ACIDS RESEARCH

Efficient chromosomal gene modification with CRISPR/cas9 and PCR-based homologous recombination donors in cultured Drosophila cells

(2014) R. Bottcher et al.   NUCLEIC ACIDS RESEARCH

Transcribing through the nucleosome

(2014) Sheila S. Teves et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tri-track: Free Software for Large-Scale Particle Tracking

(2013) Pascal Vallotton et al.   MICROSCOPY AND MICROANALYSIS

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification

(2013) Peter Tessarz et al.   NATURE

Extensive transcriptional heterogeneity revealed by isoform profiling

(2013) Vicent Pelechano et al.   NATURE

Single-molecule imaging of transcription factor binding to DNA in live mammalian cells

(2013) J Christof M Gebhardt et al.   NATURE METHODS

Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription

(2013) Sílvia Carvalho et al.   NUCLEIC ACIDS RESEARCH

Eukaryotic Replisome Components Cooperate to Process Histones During Chromosome Replication

(2013) Magdalena Foltman et al.   Cell Reports

A Universal RNA Polymerase II CTD Cycle Is Orchestrated by Complex Interplays between Kinase, Phosphatase, and Isomerase Enzymes along Genes

(2012) Alain R. Bataille et al.   MOLECULAR CELL

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

The role of FACT in making and breaking nucleosomes

(2011) Tim Formosa   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Nascent transcript sequencing visualizes transcription at nucleotide resolution

(2011) L. Stirling Churchman et al.   NATURE

Epigenome characterization at single base-pair resolution

(2011) J. G. Henikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II

(2010) S. H. Kwon et al.   GENES & DEVELOPMENT

Ubiquitylation of FACT by the Cullin-E3 ligase Rtt101 connects FACT to DNA replication

(2010) J. Han et al.   GENES & DEVELOPMENT

Phosphorylated Pol II CTD Recruits Multiple HDACs, Including Rpd3C(S), for Methylation-Dependent Deacetylation of ORF Nucleosomes

(2010) Chhabi K. Govind et al.   MOLECULAR CELL

A Complete Set of Nascent Transcription Rates for Yeast Genes

(2010) Vicent Pelechano et al.   PLoS One

DSIF and RNA Polymerase II CTD Phosphorylation Coordinate the Recruitment of Rpd3S to Actively Transcribed Genes

(2010) Simon Drouin et al.   PLoS Genetics

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

FACT facilitates chromatin transcription by RNA polymerases I and III

(2009) Joanna L Birch et al.   EMBO JOURNAL

Mapping the local protein interactome of the NuA3 histone acetyltransferase

(2009) Sherri K. Smart et al.   PROTEIN SCIENCE

A compiled and systematic reference map of nucleosome positions across the Saccharomyces cerevisiae genome

(2009) Cizhong Jiang et al.   GENOME BIOLOGY

HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis

(2008) Georgyi V. Los et al.   ACS Chemical Biology

H2B Ubiquitylation Plays a Role in Nucleosome Dynamics during Transcription Elongation

(2008) Alastair B. Fleming et al.   MOLECULAR CELL

The Anchor-Away Technique: Rapid, Conditional Establishment of Yeast Mutant Phenotypes

(2008) Hirohito Haruki et al.   MOLECULAR CELL

Chromatin- and Transcription-Related Factors Repress Transcription from within Coding Regions throughout the Saccharomyces cerevisiae Genome

(2008) Vanessa Cheung et al.   PLOS BIOLOGY