Leber’s hereditary optic neuropathy: Current approaches and future perspectives on Mesenchymal stem cell-mediated rescue

Stable transplantation of human mitochondrial DNA by high-throughput, pressurized isolated mitochondrial delivery

(2021) Alexander J Sercel et al.   eLife

Hereditary Optic Neuropathies: Induced Pluripotent Stem Cell-Based 2D/3D Approaches

(2021) Marta García-López et al.   Genes

Challenges and advances in clinical applications of mesenchymal stromal cells

(2021) Tian Zhou et al.   Journal of Hematology & Oncology

The association between multiple risk factors, clinical correlations and molecular insights in Parkinson’s disease patients from Tamil Nadu population, India

(2021) Dhivya Venkatesan et al.   NEUROSCIENCE LETTERS

KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis

(2021) Dechao Bu et al.   NUCLEIC ACIDS RESEARCH

Does retina play a role in Parkinson's Disease?

(2020) Subramaniam Mohana Devi et al.   ACTA NEUROLOGICA BELGICA

Systemic Mesenchymal Stem Cell Treatment Mitigates Structural and Functional Retinal Ganglion Cell Degeneration in a Mouse Model of Multiple Sclerosis

(2020) Oliver W. Gramlich et al.   Translational Vision Science & Technology

Generation of a human iPSC line, FINCBi001-A, carrying a homoplasmic m.G3460A mutation in MT-ND1 associated with Leber’s Hereditary optic Neuropathy (LHON)

(2020) Camille Peron et al.   Stem Cell Research

Stable retention of chloramphenicol-resistant mtDNA to rescue metabolically impaired cells

(2020) Emma R. Dawson et al.   Scientific Reports

Potential of mesenchymal stem cells as topical immunomodulatory cell therapies for ocular surface inflammatory disorders

(2020) Lydia J. Beeken et al.   Stem Cells Translational Medicine

Whole Mitochondrial Genome Analysis in Serbian Cases of Leber’s Hereditary Optic Neuropathy

(2020) Phepy G. A. Dawod et al.   Genes

Mesenchymal Stem Cells as a Promising Cell Source for Integration in Novel In Vitro Models

(2020) Ann-Kristin Afflerbach et al.   Biomolecules

Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy

(2020) Patrick Yu-Wai-Man et al.   Science Translational Medicine

Pressure-Driven Mitochondrial Transfer Pipeline Generates Mammalian Cells of Desired Genetic Combinations and Fates

(2020) Alexander N. Patananan et al.   Cell Reports

Sex Hormones and Optic Nerve Disorders: A Review

(2019) Raffaele Nuzzi et al.   Frontiers in Neuroscience

Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene

(2019) Céline Bouquet et al.   JAMA Ophthalmology

Challenges and Controversies in Human Mesenchymal Stem Cell Therapy

(2019) Barbara Lukomska et al.   Stem Cells International

Concise Review: Challenges in Clinical Development of Mesenchymal Stromal/Stem Cells

(2019) Ilenia Mastrolia et al.   Stem Cells Translational Medicine

Mitochondrial Calcium Uniporter as a potential therapeutic strategy for Alzheimer’s disease (AD)

(2019) Venugopal Anila et al.   ACTA NEUROPSYCHIATRICA

Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve

(2019) Vivien Gaillet et al.   Nature Biomedical Engineering

Leber’s Hereditary Optic Neuropathy as a Promising Disease for Gene Therapy Development

(2019) Cuneyt Karaarslan   ADVANCES IN THERAPY

An update on retinal prostheses

(2019) Lauren N. Ayton et al.   CLINICAL NEUROPHYSIOLOGY

Potential therapeutic application of mesenchymal stem cells in ophthalmology

(2019) E. Yu Zakirova et al.   EXPERIMENTAL EYE RESEARCH

Choroidal thickness and the retinal ganglion cell complex in chronic Leberʼs hereditary optic neuropathy: a prospective study using swept-source optical coherence tomography

(2019) Fatemeh Darvizeh et al.   EYE

Mesenchymal stromal cells in cancer: a review of their immunomodulatory functions and dual effects on tumor progression

(2019) Sabine Galland et al.   JOURNAL OF PATHOLOGY

A novel mutation in the mitochondrial MT-ND5 gene in a family with MELAS. The relevance of genetic analysis on targeted tissues

(2019) Luísa Panadés-de Oliveira et al.   MITOCHONDRION

Bioactivity and gene expression profiles of hiPSC-generated retinal ganglion cells in MT-ND4 mutated Leber's hereditary optic neuropathy

(2018) You-Ren Wu et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases

(2018) Serge Grazioli et al.   Frontiers in Immunology

Current and Emerging Treatment Modalities for Leber’s Hereditary Optic Neuropathy: A Review of the Literature

(2018) Anna Theodorou-Kanakari et al.   ADVANCES IN THERAPY

Whole exome sequencing revealed a novel mutation of MT-ND5 gene in a mitochondrial cardiomyopathy pedigree: patients showed biventricular hypertrophy, hyperlactacidemia, pulmonary hypertension, decreased exercise tolerance

(2018) Nianwei Zhou   Anatolian Journal of Cardiology

Pharmaceutical Development of AAV-Based Gene Therapy Products for the Eye

(2018) Gerard A. Rodrigues et al.   PHARMACEUTICAL RESEARCH

Novel MT-ND5 gene mutation identified in Leber's hereditary optic neuropathy patient using mitochondrial genome sequencing

(2017) Moon-Woo Seong et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The promise of stem cell-based therapeutics in ophthalmology

(2017) Nitza Goldenberg-Cohen et al.   Neural Regeneration Research

Gene Therapy for Leber Hereditary Optic Neuropathy

(2017) John Guy et al.   OPHTHALMOLOGY

Enhancement of Mitochondrial Transfer by Antioxidants in Human Mesenchymal Stem Cells

(2017) Chia-Jung Li et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Transfer from Wharton’s Jelly Mesenchymal Stem Cell to MERRF Cybrid Reduces Oxidative Stress and Improves Mitochondrial Bioenergetics

(2017) Yao-Chung Chuang et al.   Oxidative Medicine and Cellular Longevity

Modulation of oxidative phosphorylation and redox homeostasis in mitochondrial NDUFS4 deficiency via mesenchymal stem cells

(2017) Marlen Melcher et al.   Stem Cell Research & Therapy

Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications

(2017) Andrés Caicedo et al.   Stem Cells International

Human bone marrow mesenchymal stem cells for retinal vascular injury

(2016) Jin-Da Wang et al.   ACTA OPHTHALMOLOGICA

Study of mitochondrial respiratory defects on reprogramming to human induced pluripotent stem cells

(2016) Sandy Hung et al.   Aging-US

Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells

(2016) Ting-Hsiang Wu et al.   Cell Metabolism

Scanning Electron Microscopic Analysis of Biofilm Formation in Explanted Human Boston Type I Keratoprostheses

(2016) Kavitha R. Sivaraman et al.   CORNEA

Intercellular mitochondrial transfer: bioenergetic crosstalk between cells

(2016) Pratik Sinha et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Infections after keratoprosthesis

(2016) Emma Davies et al.   CURRENT OPINION IN OPHTHALMOLOGY

Biochemical evidence for a mitochondrial genetic modifier in the phenotypic manifestation of Leber’s hereditary optic neuropathy-associated mitochondrial DNA mutation

(2016) Pingping Jiang et al.   HUMAN MOLECULAR GENETICS

Gene Therapy for Leber Hereditary Optic Neuropathy

(2016) William J. Feuer et al.   OPHTHALMOLOGY

Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage

(2016) Dan Jiang et al.   Cell Death & Disease

Mesenchymal stem cells and immunomodulation: current status and future prospects

(2016) F Gao et al.   Cell Death & Disease

Characteristics of Mitochondrial Transformation into Human Cells

(2016) E. E. Kesner et al.   Scientific Reports

Magnetomitotransfer: An efficient way for direct mitochondria transfer into cultured human cells

(2016) Tanja Macheiner et al.   Scientific Reports

Stem Cell Therapy for Treatment of Ocular Disorders

(2016) Padma Priya Sivan et al.   Stem Cells International

Bone Marrow-Derived Cells as a Therapeutic Approach to Optic Nerve Diseases

(2016) Louise A. Mesentier-Louro et al.   Stem Cells International

iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy

(2016) Yuelin Zhang et al.   Stem Cell Reports

Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials

(2016) Sonia Labrador-Velandia et al.   World Journal of Stem Cells

Human mesenchymal stem cells - current trends and future prospective

(2015) Imran Ullah et al.   BIOSCIENCE REPORTS

Restoration of vision in blind individuals using bionic devices: A review with a focus on cortical visual prostheses

(2015) Philip M. Lewis et al.   BRAIN RESEARCH

Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells

(2015) X Wang et al.   CELL DEATH AND DIFFERENTIATION

Is there treatment for Leber hereditary optic neuropathy?

(2015) Jason H. Peragallo et al.   CURRENT OPINION IN OPHTHALMOLOGY

Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse

(2015) Alfred K. Yu et al.   HUMAN MOLECULAR GENETICS

NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data

(2015) Jianguo Xia et al.   Nature Protocols

Molecular Mechanisms Mediating Retinal Reactive Gliosis Following Bone Marrow Mesenchymal Stem Cell Transplantation

(2015) Alessia Tassoni et al.   STEM CELLS

Cigarette toxicity triggers Leber’s hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways

(2015) L Giordano et al.   Cell Death & Disease

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function

(2015) Andrés Caicedo et al.   Scientific Reports

Improving the Post-Stroke Therapeutic Potency of Mesenchymal Multipotent Stromal Cells by Cocultivation With Cortical Neurons: The Role of Crosstalk Between Cells

(2015) Valentina A. Babenko et al.   Stem Cells Translational Medicine

Mitochondrial damage-associated molecular patterns and vascular function

(2014) C. F. Wenceslau et al.   EUROPEAN HEART JOURNAL

Three-parent in vitro fertilization: gene replacement for the prevention of inherited mitochondrial diseases

(2014) Paula Amato et al.   FERTILITY AND STERILITY

Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency

(2014) Immo E. Scheffler   JOURNAL OF INHERITED METABOLIC DISEASE

Miro 1 Knockdown in Stem Cells Inhibits Mitochondrial Donation Mediated Rescue of Bronchial Epithelial Injury

(2013) Tanveer Ahmad et al.   BIOPHYSICAL JOURNAL

Efficient mitochondrial biogenesis drives incomplete penetrance in Leber’s hereditary optic neuropathy

(2013) Carla Giordano et al.   BRAIN

Immunological characteristics of human mesenchymal stem cells and multipotent adult progenitor cells

(2013) Sandra A Jacobs et al.   IMMUNOLOGY AND CELL BIOLOGY

Immunology of AAV-Mediated Gene Transfer in the Eye

(2013) Keirnan Willett et al.   Frontiers in Immunology

Functional Recovery of Human Cells Harbouring the Mitochondrial DNA Mutation MERRF A8344G via Peptide-Mediated Mitochondrial Delivery

(2012) Jui-Chih Chang et al.   NEUROSIGNALS

Rare Primary Mitochondrial DNA Mutations and Probable Synergistic Variants in Leber’s Hereditary Optic Neuropathy

(2012) Alessandro Achilli et al.   PLoS One

Leber hereditary optic neuropathy and oxidative stress

(2012) Y. Zhuo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model

(2012) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biocompatibility and biofilm inhibition of N,N-hexyl,methyl-polyethylenimine bonded to Boston Keratoprosthesis materials

(2011) Irmgard Behlau et al.   BIOMATERIALS

Atypical presentation of Leigh syndrome associated with a Leber hereditary optic neuropathy primary mitochondrial DNA mutation

(2011) Gary Fruhman et al.   MOLECULAR GENETICS AND METABOLISM

Induction of Rapid and Highly Efficient Expression of the Human ND4 Complex I Subunit in the Mouse Visual System by Self-complementary Adeno-Associated Virus

(2010) Rajeshwari D. Koilkonda   ARCHIVES OF OPHTHALMOLOGY

DNA methylation status of nuclear-encoded mitochondrial genes underlies the tissue-dependent mitochondrial functions

(2010) Masaki Takasugi et al.   BMC GENOMICS

A Mesoderm-Derived Precursor for Mesenchymal Stem and Endothelial Cells

(2010) Maxim A. Vodyanik et al.   Cell Stem Cell

Mesenchymal Stem Cells and Potential Applications in Treating Ocular Disease

(2010) Aaron W Joe et al.   CURRENT EYE RESEARCH

NDUFS4 mutations cause Leigh syndrome with predominant brainstem involvement

(2009) E. Leshinsky-Silver et al.   MOLECULAR GENETICS AND METABOLISM

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

(2008) Wolfgang Wagner et al.   PLoS One