Type 3 secretion system as an anti-Pseudomonal target

A pipeline to evaluate inhibitors of the Pseudomonas aeruginosa Exotoxin U

(2021) Daniel Morgan Foulkes et al.   BIOCHEMICAL JOURNAL

Iron Chelation in Local Infection

(2021) Cassidy Scott et al.   MOLECULES

Identification of Small Molecules Blocking the Pseudomonas aeruginosa Type III Secretion System Protein PcrV

(2021) Charlotta Sundin et al.   Biomolecules

Type 3 secretion system of Pseudomonas aeruginosa

(2021) Gertrudis Horna et al.   MICROBIOLOGICAL RESEARCH

Type three secretion system in Salmonella Typhimurium: the key to infection

(2020) Anamaria M. P. dos Santos et al.   Genes & Genomics

Exploring resveratrol dimers as virulence blocking agents – Attenuation of type III secretion in Yersinia pseudotuberculosis and Pseudomonas aeruginosa

(2020) Charlotta Sundin et al.   Scientific Reports

Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone

(2020) Inácio Mandomando et al.   PLoS Neglected Tropical Diseases

Antimicrobial resistance and virulence of Pseudomonas spp. among healthy animals: concern about exolysin ExlA detection

(2020) Lidia Ruiz-Roldán et al.   Scientific Reports

Exoenzyme Y Contributes to End-Organ Dysfunction Caused by Pseudomonas aeruginosa Pneumonia in Critically Ill Patients: An Exploratory Study

(2020) Brant M. Wagener et al.   Toxins

Cell Death Signaling Pathway Induced by Cholix Toxin, a Cytotoxin and eEF2 ADP-Ribosyltransferase Produced by Vibrio cholerae

(2020) Kohei Ogura et al.   Toxins

Synthesis and biological evaluation of 1,3,4-thiadiazole derivatives as type III secretion system inhibitors against Xanthomonas oryzae

(2019) Hui Tao et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

High frequency of the exoU+/exoS+ genotype associated with multidrug-resistant “high-risk clones” of Pseudomonas aeruginosa clinical isolates from Peruvian hospitals

(2019) Gertrudis Horna et al.   Scientific Reports

Tanshinones: First-in-Class Inhibitors of the Biogenesis of the Type 3 Secretion System Needle of Pseudomonas aeruginosa for Antibiotic Therapy

(2019) Chao Feng et al.   ACS Central Science

Modulating pathogenesis with Mobile-CRISPRi

(2019) Jiuxin Qu et al.   JOURNAL OF BACTERIOLOGY

Novel S-Thiazol-2-yl-furan-2-carbothioate Derivatives as Potential T3SS Inhibitors Against Xanthomonas oryzae on Rice

(2019) Shan Jiang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

KB001-A, a novel anti-inflammatory, found to be safe and well-tolerated in cystic fibrosis patients infected with Pseudomonas aeruginosa

(2018) R. Jain et al.   Journal of Cystic Fibrosis

Phase 1 study of MEDI3902, an investigational anti–Pseudomonas aeruginosa PcrV and Psl bispecific human monoclonal antibody, in healthy adults

(2018) S.O. Ali et al.   CLINICAL MICROBIOLOGY AND INFECTION

Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice

(2018) Anna B. Sheremet et al.   Biomed Research International

Specific type IV pili groups in clinical isolates of Pseudomonas aeruginosa

(2018) Gertrudis Horna et al.   INTERNATIONAL MICROBIOLOGY

Host and Pathogen Biomarkers for Severe Pseudomonas aeruginosa Infections

(2017) Carlos Juan et al.   JOURNAL OF INFECTIOUS DISEASES

Protective Efficacy of the Trivalent Pseudomonas aeruginosa Vaccine Candidate PcrV-OprI-Hcp1 in Murine Pneumonia and Burn Models

(2017) Feng Yang et al.   Scientific Reports

Pathogenicity Island O-122 in enteropathogenic Escherichia coli strains is associated with diarrhea severity in children from Lima Peru

(2016) Erik H. Mercado et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Targeting the Type Three Secretion System in Pseudomonas aeruginosa

(2016) Ahalieyah Anantharajah et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibition of Pseudomonas aeruginosa ExsA DNA-Binding Activity byN-Hydroxybenzimidazoles

(2015) Anne E. Marsden et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enhanced annotations and features for comparing thousands ofPseudomonasgenomes in the Pseudomonas genome database

(2015) Geoffrey L. Winsor et al.   NUCLEIC ACIDS RESEARCH

Mutations in the Pseudomonas aeruginosa Needle Protein GenepscFConfer Resistance to Phenoxyacetamide Inhibitors of the Type III Secretion System

(2014) Nicholas O. Bowlin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparative Systems Biology Analysis To Study the Mode of Action of the Isothiocyanate Compound Iberin on Pseudomonas aeruginosa

(2014) Sean Yang-Yi Tan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Correction: Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen

(2014) Anthony Arnoldo et al.   PLoS Genetics

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

(2013) David Bikard et al.   NUCLEIC ACIDS RESEARCH

Anti-PcrV antibody in cystic fibrosis: A novel approach targetingPseudomonas aeruginosaairway infection

(2013) Carlos E. Milla et al.   PEDIATRIC PULMONOLOGY

The Resveratrol Tetramer (-)-Hopeaphenol Inhibits Type III Secretion in the Gram-Negative Pathogens Yersinia pseudotuberculosis and Pseudomonas aeruginosa

(2013) Caroline E. Zetterström et al.   PLoS One

Th17-stimulating Protein Vaccines Confer Protection againstPseudomonas aeruginosaPneumonia

(2012) Weihui Wu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Food as a Source for Quorum Sensing Inhibitors: Iberin from Horseradish Revealed as a Quorum Sensing Inhibitor of Pseudomonas aeruginosa

(2012) Tim Holm Jakobsen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Safety and pharmacokinetics of an anti-PcrV PEGylated monoclonal antibody fragment in mechanically ventilated patients colonized with Pseudomonas aeruginosa

(2012) Bruno François et al.   CRITICAL CARE MEDICINE

The Non-Flagellar Type III Secretion System Evolved from the Bacterial Flagellum and Diversified into Host-Cell Adapted Systems

(2012) Sophie S. Abby et al.   PLoS Genetics

Derivatives of Plant Phenolic Compound Affect the Type III Secretion System of Pseudomonas aeruginosa via a GacS-GacA Two-Component Signal Transduction System

(2011) Akihiro Yamazaki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Modified Needle-Tip PcrV Proteins Reveal Distinct Phenotypes Relevant to the Control of Type III Secretion and Intoxication by Pseudomonas aeruginosa

(2011) Hiromi Sato et al.   PLoS One

Role of Pseudomonas aeruginosa type III effectors in disease

(2009) Joanne Engel et al.   CURRENT OPINION IN MICROBIOLOGY

The type III secretion system of Pseudomonas aeruginosa: infection by injection

(2009) Alan R. Hauser   NATURE REVIEWS MICROBIOLOGY