Can hydroxyurea serve as a free radical scavenger and reduce iron overload in β-thalassemia patients?

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

(2015) D.J.R. Lane et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Estimating tissue iron burden: current status and future prospects

(2015) John C. Wood   BRITISH JOURNAL OF HAEMATOLOGY

Iron and oxidative stress in cardiomyopathy in thalassemia

(2015) Vasilios Berdoukas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress in β-thalassaemia and sickle cell disease

(2015) S. Voskou et al.   Redox Biology

Labile iron in cells and body fluids: physiology, pathology, and pharmacology

(2014) Zvi Ioav Cabantchik   Frontiers in Pharmacology

New insights provided by a comparison of impaired deformability with erythrocyte oxidative stress for sickle cell disease

(2013) Viachaslau M. Barodka et al.   BLOOD CELLS MOLECULES AND DISEASES

Inborn defects in the antioxidant systems of human red blood cells

(2013) Rob van Zwieten et al.   FREE RADICAL BIOLOGY AND MEDICINE

Systemic Iron Homeostasis

(2013) Tomas Ganz   PHYSIOLOGICAL REVIEWS

Hydroxyurea Could Be a Good Clinically Relevant Iron Chelator

(2013) Khushnooma Italia et al.   PLoS One

Interactions Of Hydroxycarbamide (Hydroxyurea) With Iron And Copper: Implications On Toxicity and Therapeutic Strategies

(2011) Eleni Konstantinou et al.   HEMOGLOBIN

Antiradical, Chelating and Antioxidant Activities of Hydroxamic Acids and Hydroxyureas

(2011) Marijana Zovko Končić et al.   MOLECULES

Effect of hydroxyurea on the transfusion requirements in patients with severe HbE- -thalassaemia: a genotypic and phenotypic study

(2010) K. Y. Italia et al.   JOURNAL OF CLINICAL PATHOLOGY

Transferrin therapy ameliorates disease in β-thalassemic mice

(2010) Huihui Li et al.   NATURE MEDICINE

Aminophospholipid translocase and phospholipid scramblase activities in sickle erythrocyte subpopulations

(2009) Latorya A. Barber et al.   BRITISH JOURNAL OF HAEMATOLOGY

Response to hydroxyurea in β thalassemia major and intermedia: Experience in western India

(2009) Khushnooma Y. Italia et al.   CLINICA CHIMICA ACTA

Hydroxyurea Generates Nitric Oxide in Human Erythroid Cells: Mechanisms for γ-Globin Gene Activation

(2009) Tzu-Fang Lou et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Hydroxyurea in sickle cell disease—A study of clinico-pharmacological efficacy in the Indian haplotype

(2008) K ITALIA et al.   BLOOD CELLS MOLECULES AND DISEASES

Hydroxyurea for the Treatment of Sickle Cell Anemia

(2008) Orah S. Platt   NEW ENGLAND JOURNAL OF MEDICINE

Oral Iron Chelators

(2008) Janet L. Kwiatkowski   PEDIATRIC CLINICS OF NORTH AMERICA

Flow cytometry measurement of the labile iron pool in human hematopoietic cells

(2007) Eugenia Prus et al.   CYTOMETRY PART A