Article
Multidisciplinary Sciences
Rattanawan Thubthed, Sirikwan Siriworadetkun, Kittiphong Paiboonsukwong, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas, Saovaros Svasti, Pornthip Chaichompoo
Summary: This study found that neutrophil dysfunction, including neutrophil extracellular trap (NET) formation, contributes to increased susceptibility to severe bacterial infection in beta-thalassaemia/HbE patients. The impaired development of late-phase NETs in splenectomised patients may lead to higher susceptibility to bacterial infection.
SCIENTIFIC REPORTS
(2022)
Article
Hematology
Sirikwan Siriworadetkun, Chayada Thiengtavor, Rattanawan Thubthed, Kittiphong Paiboonsukwong, I. Suthat I. Fucharoen, Kovit Pattanapanyasat, Jim Vadolas, Saovaros Svasti, Pornthip Chaichompoo
Summary: This study investigated the effects of HU treatment on the immune response in thalassacemia patients and found that HU therapy does not significantly compromise the immune response.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, General & Internal
Hanan Kamel M. Saad, Wan Rohani Wan Taib, Azly Sumanty Ab Ghani, Imilia Ismail, Futoon Abedrabbu Al-Rawashde, Belal Almajali, Maysa Alhawamdeh, Alawiyah Awang Abd Rahman, Abdullah Saleh Al-wajeeh, Hamid Ali Nagi Al-Jamal
Summary: This study investigated the spectrum of β-thalassaemia gene mutations and their correlation with iron overload in HbE/β-thalassaemia patients, β-thalassaemia carriers, and HbE carriers. It was found that some mutations were associated with severe anaemia in patients, and the detection of mutations can serve as a prognostic marker to improve the management protocols and haematological and biochemical statuses of β-thalassaemia patients.
Review
Hematology
Rayan Bou-Fakhredin, Irene Motta, Maria Domenica Cappellini
Summary: This review provides an overview of the novel therapeutic approaches currently being developed to advance the care of β-thalassaemia patients, which have the potential to reduce transfusion burden, raise haemoglobin levels, and improve patients' quality of life.
Article
Hematology
Burhan Abdullah Zaman, Suzan Omer Rasool, Jassim Mohammed Abdo
Summary: In this study, we investigated the changes in the EPO-ERFE-hepcidin axis after transfusion in beta-thalassaemia major patients. We found increased levels of post-transfusion haemoglobin, hepcidin, and ferritin, while EPO, ERFE, and soluble transferrin receptor were suppressed. Additionally, the change in hepcidin was inversely associated with changes in erythropoiesis, as indicated by the increase in the hepcidin-to-ERFE ratio after transfusion.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Pairunyar Nakavachara, Praewvarin Weerakulwattana, Julaporn Pooliam, Vip Viprakasit
Summary: This study aimed to explore the prevalence and related factors of low bone mass in children with transfusion-dependent (TD) or non-transfusion-dependent (NTD) hemoglobin E/beta-thalassemia. The results showed that most of the children had normal bone mineral density (BMD), but TD patients had lower total body BMD than NTD patients. The prevalence of low lumbar spine bone mass was significantly higher in the TD group than in the NTD group.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Infectious Diseases
Selvi C. Ersoy, Warren E. Rose, Robin Patel, Richard A. Proctor, Henry F. Chambers, Ewan M. Harrison, Youngju Pak, Arnold S. Bayer
Summary: Antimicrobial susceptibility testing (AST) is used to predict antibiotic resistance in bacterial pathogens for treatment. A novel phenotype, NaHCO3-responsiveness, was identified in clinical MRSA strains, showing susceptibility to beta-lactams in the presence of NaHCO3. Combining AMC disk susceptibility testing with mecA and spa genotyping can predict MRSA strains' responsiveness to NaHCO3 with high sensitivity and specificity.
Article
Dentistry, Oral Surgery & Medicine
Juliana Marulanda, Jean-Marc Retrouvey, Brendan Lee, V. Reid Sutton, Frank Rauch, Michelle Briner
Summary: This study used CBCT scans to assess cranio-cervical anomalies and clinical findings in patients with moderate-to-severe OI. The results showed that patients with OI had a flatter cranial base and a higher prevalence of odontoid process abnormalities compared to healthy controls. Low stature, presence of DI, and being male were strong predictors of cranio-cervical anomalies in OI patients.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2023)
Article
Environmental Sciences
Kumar Kavinesan, Gopalrajan Sugumar, Bagthasingh Chrisolite, Andiappan Muthiahsethupathy, Shanmugam Sudarshan, Fathiraja Parthiban, Mohamed Mansoor
Summary: The ubiquity of pathogenic E. coli isolate with antimicrobial resistance was investigated in seafood samples from Tuticorin coast. The study found that out of 63 seafood samples, 46% were contaminated with pathogenic E. coli carrying virulent genes. Multi-drug resistance and extended spectrum of beta-lactamase (ESBL) were observed in a significant percentage of the isolates. The study emphasizes the importance of surveillance and monitoring of pathogenic E. coli and antimicrobial resistant genes in seafood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Surgery
Jong Wook Song, Sarah Soh, Jae-Kwang Shim, Sak Lee, Seung Hyun Lee, Hye Bin Kim, Min-Yu Kim, Young Lan Kwak
Summary: Intravenous iron supplementation during index hospitalization for complex cardiac surgery did not minimize packed erythrocytes transfusion, despite higher hemoglobin concentration and reticulocyte count in the iron group.
Review
Genetics & Heredity
Nirmani Yasara, Anuja Premawardhena, Sachith Mettananda
Summary: Hydroxyurea, an early promising drug in the management of haemoglobinopathies, has become a valuable adjunct to transfusion therapy for beta-haemoglobinopathy patients during the COVID-19 pandemic. It exerts favorable effects on patients by inducing fetal haemoglobin and inhibiting ribonucleoside diphosphate reductase enzyme, but its usefulness in transfusion dependent beta-thalassaemia needs to be confirmed by clinical trials.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Genetics & Heredity
Michalis Georgiou, Naser Ali, Elizabeth Yang, Parampal S. Grewal, Tryfon Rotsos, Nikolas Pontikos, Anthony G. Robson, Michel Michaelides
Summary: This study presents detailed retinal phenotypes of patients with Leber Congenital Amaurosis/Early-Onset Severe Retinal Dystrophy caused by sequence variants in four genes. The findings expand the phenotypic and genotypic spectrum of these diseases, emphasizing the importance of retinal and functional phenotyping and specific genetic diagnosis for potential future therapy.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Hematology
Marta Caballero, Antoni Sabate, Rosa Gutierrez, Joan Beltran, Lourdes Perez, Roger Pujol, Laura Viguera, Marta Costa, Raquel Reyes, Alberto Martinez, Gorka Ojinaga, Ariadna Leon, Antonio Navarro, Marta Barquero, Guillermo Alonso, Guillermo Puig, Annabel Blasi
Summary: This study aimed to investigate whether infusions of fibrinogen concentrate to reach an A10FIBTEM value of 11 mm during liver transplantation could reduce red blood cell and other component and fluid requirements compared to standard care. The results showed that fibrinogen replacement did not reduce the proportion of patients requiring red blood cell transfusion, and there was no significant difference between the intervention group and the control group.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Parul Rai, Vijaya M. Joshi, Jason F. Goldberg, Amber M. Yates, Victoria Okhomina, Rhiannon Penkert, Kenneth Ataga, Guolian Kang, Jane S. Hankins
Summary: Hydroxyurea therapy may help mitigate TRV elevation in children with SCA, possibly as a result of a reduction in hemolysis and improvement in anemia.
Article
Microbiology
Saeedeh Robatjazi, Farhad Nikkhahi, Mojtaba Niazadeh, Seyed Mahmoud Amin Marashi, Amir Peymani, Amir Javadi, Amir Hossein Kashani
Summary: This study aimed to assess the AmpC beta-lactamases in Klebsiella pneumoniae and Escherichia coli clinical isolates in Qazvin, Iran, showing that some isolates expressed AmpC genes. Multiplex PCR and various confirmatory tests can be used to detect AmpC beta-lactamase-producing strains.
CURRENT MICROBIOLOGY
(2021)
Article
Hematology
Avani Shah, Parizad Patel, Keyur Patel, Binal Patel, Keyuri Jariwala, Preeti Sharma, Kanchan Mishra, Kanjaksha Ghosh
TRANSFUSION AND APHERESIS SCIENCE
(2020)
Letter
Rheumatology
Kanjaksha Ghosh
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, Research & Experimental
Salam Alkindi, Said S. Almufargi, Anil Pathare
EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Article
Multidisciplinary Sciences
Salam Alkindi, Ikhlas Al-Busaidi, Bushra Al-Salami, Samir Raniga, Anil Pathare, Samir K. Ballas
SCIENTIFIC REPORTS
(2020)
Article
Hematology
Avani Shah, Parizad Patel, Keyuri Jariwala, Farzin Qureshi, Kanchan Mishra, Sumit Bharadva, Kanjaksha Ghosh
Summary: There is a lack of data on the prevalence of rare blood group antigens among the blood donor population in South Gujarat due to the unavailability and high cost of antisera. This study used a PCR-based method to detect the presence of In-a and In-b antigens in regular voluntary blood donors. The frequency of In a antigen was found to be higher than Caucasians, lower than Iranians and Arabs, and comparable to Indians in Mumbai. This PCR-based method could be extremely helpful in creating a rare donor registry and screening blood donors on a large scale in the absence of antisera, particularly for low-frequency alleles like In-a.
TRANSFUSION AND APHERESIS SCIENCE
(2022)
Article
Medicine, General & Internal
Naglaa Fawaz, Ismail Beshlawi, Alauldeen Alqasim, Mathew Zachariah, Roberta Russo, Immacolata Andolfo, Antonella Gambale, Anil Pathare, Achille Iolascon
Summary: We report a case of transfusion-dependent chronic anemia in a child, with clinical and laboratory features suggestive of a chronic nonspherocytic hemolytic anemia and bone marrow features suggestive of congenital dyserythropoietic anemia. However, DNA studies revealed a novel mutation in the PKLR gene responsible for pyruvate kinase deficiency as the underlying condition. Molecular investigations using targeted next-generation sequencing identified the patient as homozygous for a novel missense mutation, while both parents were heterozygous for the same mutation.
CLINICAL CASE REPORTS
(2022)
Review
Hematology
Kanjaksha Ghosh, Kinjalka Ghosh
Summary: Monoclonal antibodies are increasingly used in hematology practice, either alone or in combination with other therapies, to improve outcomes in various hematological conditions. These antibodies have a wide range of applications in malignant and benign hematological diseases, as well as in different phases of stem cell transplantation. Advancements in protein engineering are rapidly improving the function of antibodies.
EXPERT REVIEW OF HEMATOLOGY
(2022)
Review
Medicine, Research & Experimental
Kanjaksha Ghosh, Durjoy K. Shome, Bipin Kulkarni, Malay K. Ghosh, Kinjalka Ghosh
Summary: Bone marrow fibrosis is a significant structural change in the marrow that is not well understood in terms of its causes. This review consolidates the current understanding of marrow fibrosis, highlighting the complex interactions between growth factors, cytokines, chemokines, and hormones. The involvement of various cells, molecules, and genetic/epigenetic changes in the fibrosis process is also discussed.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Suryyani Deb, Mohammad Azharuddin, Sofia Ramstrom, Kanjaksha Ghosh, Santiswarup Singha, Thobias Romu, Hirak Kumar Patra
Summary: Arterial thrombosis is caused by platelet-mediated thrombus formation in blood vessels, leading to severe cardiovascular diseases. To better predict and treat arterial thrombosis, we have developed a nanoparticle platform that can simultaneously monitor and restrict thrombus growth. The platform works by inhibiting receptors on platelets and visualizing the thrombus status through magnetic resonance imaging.
BIOENGINEERING-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Prashant P. Warang, Nikhil S. Shinde, Vinod D. Umare, Prajyot Deshmukh, Kanjaksha Ghosh, Manisha R. Madkaikar, Roshan B. Colah, Malay B. Mukherjee
Summary: This study evaluated the effects of fermented papaya preparation (FPP) on sickle cell patients, finding that it has the potential to reduce oxidative stress and protect red blood cell morphology. The analysis also revealed the presence of essential amino acids and vitamin D3 and derivatives in FPP.
Article
Biochemistry & Molecular Biology
Vinod Umare, Vandana Pradhan, Sneha Dadheech, Anjali Rajadhyaksha, Kanjaksha Ghosh, Anita Nadkarni
Article
Pathology
Sandhya Tamgadge, Treville Pereira, Sandeep Kale, Subraj Shetty, Avinash Tamgadge
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2020)
Article
Dermatology
Treville Pereira, J. Aswathy, Subraj Shetty, Avinash Tamgadge, Sandhya Tamgadge, Swati Gotmare
INDIAN DERMATOLOGY ONLINE JOURNAL
(2019)
Review
Oncology
Subraj J. Shetty, Treville Pereira, Rajiv S. Desai
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2019)
Article
Gastroenterology & Hepatology
Kanchan K. Mishra, Shashikant Srivastava, Archana Aayyagari, Kanjaksha Ghosh
INDIAN JOURNAL OF GASTROENTEROLOGY
(2019)