Proteins Associated with Risk of Kidney Function Decline in the General Population

Biomarkers of Immune Activation and Incident Kidney Failure With Replacement Therapy: Findings From the African American Study of Kidney Disease and Hypertension

(2021) Teresa K. Chen et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans

(2020) Pascal Schlosser et al.   NATURE GENETICS

Plasma Biomarkers of Tubular Injury and Inflammation Are Associated with CKD Progression in Children

(2020) Jason H. Greenberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The biomarker HE4 (WFDC2) promotes a pro-angiogenic and immunosuppressive tumor microenvironment via regulation of STAT3 target genes

(2020) Nicole E. James et al.   Scientific Reports

Circulating testican-2 is a podocyte-derived marker of kidney health

(2020) Debby Ngo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes

(2019) Monika A. Niewczas et al.   NATURE MEDICINE

Mendelian randomization analysis using mixture models for robust and efficient estimation of causal effects

(2019) Guanghao Qi et al.   Nature Communications

PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations

(2019) Mihir A Kamat et al.   BIOINFORMATICS

A catalog of genetic loci associated with kidney function from analyses of a million individuals

(2019) Matthias Wuttke et al.   NATURE GENETICS

Hypoxia‐induced HE4 in tubular epithelial cells promotes extracellular matrix accumulation and renal fibrosis via NF‐κB

(2019) Lei Zhang et al.   FASEB JOURNAL

Plasma protein patterns as comprehensive indicators of health

(2019) Stephen A. Williams et al.   NATURE MEDICINE

The urinary proteomics classifier chronic kidney disease 273 predicts cardiovascular outcome in patients with chronic kidney disease

(2019) Francis Verbeke et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

(2019) Madeline H. Kowalski et al.   PLoS Genetics

Serum human epididymis protein 4 is a predictor for developing nephritis in patients with systemic lupus erythematosus: A prospective cohort study

(2018) Yingpeng Ren et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Markers of early progressive renal decline in type 2 diabetes suggest different implications for etiological studies and prognostic tests development

(2018) Natalia Nowak et al.   KIDNEY INTERNATIONAL

Treatment of rheumatoid arthritis with biologic agents lowers the risk of incident chronic kidney disease

(2018) Keiichi Sumida et al.   KIDNEY INTERNATIONAL

Renal expression of trefoil factor 3 mRNA in association with tubulointerstitial fibrosis in IgA nephropathy

(2018) Keiko Tanaka et al.   NEPHROLOGY

An atlas of genetic associations in UK Biobank

(2018) Oriol Canela-Xandri et al.   NATURE GENETICS

HE4 Serum Levels Are Associated with Heart Failure Severity in Patients With Chronic Heart Failure

(2017) Arnold Piek et al.   JOURNAL OF CARDIAC FAILURE

Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease

(2017) Steven G. Coca et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites

(2017) Tao Long et al.   NATURE GENETICS

PhenoScanner: a database of human genotype–phenotype associations

(2016) James R. Staley et al.   BIOINFORMATICS

Mendelian Randomization as an Approach to Assess Causality Using Observational Data

(2016) P. Sekula et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genetic loci associated with renal function measures and chronic kidney disease in children: the Pediatric Investigation for Genetic Factors Linked with Renal Progression Consortium

(2015) Matthias Wuttke et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

SNiPA: an interactive, genetic variant-centered annotation browser

(2014) Matthias Arnold et al.   BIOINFORMATICS

Sequencing of LRP2 Reveals Multiple Rare Variants Associated with Urinary Trefoil Factor-3

(2014) G. M. McMahon et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Functional Genomic Annotation of Genetic Risk Loci Highlights Inflammation and Epithelial Biology Networks in CKD

(2014) N. Ledo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

 -Trace Protein: From GFR Marker to Cardiovascular Risk Predictor

(2013) E. Orenes-Pinero et al.   Clinical Journal of the American Society of Nephrology

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Circulating Serum Trefoil Factor 3 (TFF3) Is Dramatically Increased in Chronic Kidney Disease

(2013) Ting-yi Du et al.   PLoS One

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

(2012) Patrick T Ellinor et al.   NATURE GENETICS

Trefoil Factor 3 Predicts Incident Chronic Kidney Disease: A Case-Control Study Nested within the Atherosclerosis Risk in Communities (ARIC) Study

(2011) Brad C. Astor et al.   AMERICAN JOURNAL OF NEPHROLOGY

The FDA's critical path initiative: A brief introduction

(2010) Stephen Joel Coons   CLINICAL THERAPEUTICS

Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility

(2010) Tanja Zeller et al.   PLoS One

Effects of Sample Timing and Treatment on Gene Expression in Early Acute Renal Allograft Rejection

(2010) Oliver P. Günther et al.   TRANSPLANTATION

A Bayesian Framework to Account for Complex Non-Genetic Factors in Gene Expression Levels Greatly Increases Power in eQTL Studies

(2010) Oliver Stegle et al.   PLoS Computational Biology

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

(2009) Bryan N. Howie et al.   PLoS Genetics