The biomarker HE4 (WFDC2) promotes a pro-angiogenic and immunosuppressive tumor microenvironment via regulation of STAT3 target genes

Poly(ADP-ribose) polymerase inhibitors as maintenance treatment in patients with newly diagnosed advanced ovarian cancer: a meta-analysis

(2020) Ezzeldin M Ibrahim et al.   Future Oncology

Combinatorial therapy of immune checkpoint and cancer pathways provides a novel perspective on ovarian cancer treatment (Review)

(2019) Guyu Zhang et al.   Oncology Letters

Human Epididymis Secretory Protein 4 (HE4) Compromises Cytotoxic Mononuclear Cells via Inducing Dual Specificity Phosphatase 6

(2019) Nicole E. James et al.   Frontiers in Pharmacology

PARP inhibitors in platinum-sensitive high-grade serous ovarian cancer

(2018) Robert D. Morgan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The role of STAT3 in leading the crosstalk between human cancers and the immune system

(2018) Yu Wang et al.   CANCER LETTERS

HE4 suppresses the expression of osteopontin in mononuclear cells and compromises their cytotoxicity against ovarian cancer cells

(2018) Nicole E. James et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Personalising Treatment for High-Grade Serous Ovarian Carcinoma

(2018) E. Cojocaru et al.   CLINICAL ONCOLOGY

Human Epididymis Protein 4 Promotes Events Associated with Metastatic Ovarian Cancer via Regulation of the Extracelluar Matrix

(2018) Jennifer R. Ribeiro et al.   Frontiers in Oncology

Persistent restoration to the immunosupportive tumor microenvironment in glioblastoma by bevacizumab

(2018) Ryota Tamura et al.   CANCER SCIENCE

Hypoxia-Induced Upregulation of HE4 Is Responsible for Resistance to Radiation Therapy of Gastric Cancer

(2018) Chunwei Peng et al.   Molecular Therapy-Oncolytics

Serum IL-6 and IL-8 Correlate with Prognostic Factors in Ovarian Cancer

(2017) Marcela Moisés Maluf Sanguinete et al.   IMMUNOLOGICAL INVESTIGATIONS

The role of STAT3 in glioblastoma progression through dual influences on tumor cells and the immune microenvironment

(2017) Nakho Chang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Inhibition of JAK2/STAT3 reduces tumor-induced angiogenesis and myeloid-derived suppressor cells in head and neck cancer

(2017) Jian-Feng Liu et al.   MOLECULAR CARCINOGENESIS

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

(2017) Martina Schmittnaegel et al.   Science Translational Medicine

High grade serous ovarian carcinomas originate in the fallopian tube

(2017) S. Intidhar Labidi-Galy et al.   Nature Communications

Combination curcumin and (−)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway

(2017) G Jin et al.   Oncogenesis

Immune checkpoint inhibition in ovarian cancer

(2016) Junzo Hamanishi et al.   INTERNATIONAL IMMUNOLOGY

Role of human epididymis protein 4 in chemoresistance and prognosis of epithelial ovarian cancer

(2016) Seungho Lee et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Analysis of the gene expression profile in response to human epididymis protein 4 in epithelial ovarian cancer cells

(2016) Liancheng Zhu et al.   ONCOLOGY REPORTS

Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma

(2016) Jeffrey J. Wallin et al.   Nature Communications

HE4 promotes collateral resistance to cisplatin and paclitaxel in ovarian cancer cells

(2016) J. R. Ribeiro et al.   Journal of Ovarian Research

Bevacizumab in ovarian cancer: A critical review of phase III studies

(2016) Luigi Rossi et al.   Oncotarget

Persisting and Increasing Neutrophil Infiltration Associates with Gastric Carcinogenesis and E-cadherin Downregulation

(2016) Hualin Fu et al.   Scientific Reports

Regulation of PD-L1: a novel role of pro-survival signalling in cancer

(2015) J. Chen et al.   ANNALS OF ONCOLOGY

Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis

(2015) S K Srivastava et al.   BRITISH JOURNAL OF CANCER

Interleukin-8: A potent promoter of angiogenesis in gastric cancer

(2015) JUN SHI et al.   Oncology Letters

Overexpression of HE4 (human epididymis protein 4) enhances proliferation, invasion and metastasis of ovarian cancer

(2015) Liancheng Zhu et al.   Oncotarget

Overexpression of Lewis y antigen promotes human epididymis protein 4-mediated invasion and metastasis of ovarian cancer cells

(2014) Huiyu Zhuang et al.   BIOCHIMIE

Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner

(2014) Heyang Xu et al.   BMC CANCER

The Angiogenic Activity of Ascites in the Course of Ovarian Cancer as a Marker of Disease Progression

(2014) Krzysztof Gawrychowski et al.   DISEASE MARKERS

Human epididymis protein 4 in association with Annexin II promotes invasion and metastasis of ovarian cancer cells

(2014) Huiyu Zhuang et al.   Molecular Cancer

Promotive role of recombinant HE4 protein in proliferation and carboplatin resistance in ovarian cancer cells

(2014) HUAN WANG et al.   ONCOLOGY REPORTS

Expression and biochemical characterization of recombinant human epididymis protein 4

(2014) Ling Hua et al.   PROTEIN EXPRESSION AND PURIFICATION

HE4 (WFDC2) gene overexpression promotes ovarian tumor growth

(2014) Richard G. Moore et al.   Scientific Reports

Bevacizumab plus Ipilimumab in Patients with Metastatic Melanoma

(2014) F. S. Hodi et al.   Cancer Immunology Research

Vascular Normalization as an Emerging Strategy to Enhance Cancer Immunotherapy

(2013) Y. Huang et al.   CANCER RESEARCH

Interaction of monocytes/macrophages with ovarian cancer cells promotes angiogenesisin vitro

(2013) Xipeng Wang et al.   CANCER SCIENCE

Inhibition of tumour angiogenesis and growth by small hairpin HIF-1α and IL-8 in hepatocellular carcinoma

(2013) Sung Hoon Choi et al.   LIVER INTERNATIONAL

Effect of WFDC 2 silencing on the proliferation, motility and invasion of human serous ovarian cancer cells in vitro

(2013) Ya-Fei Zhu et al.   Asian Pacific Journal of Tropical Medicine

Human epididymis protein 4 (HE4) plays a key role in ovarian cancer cell adhesion and motility

(2012) Renquan Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Stat3 Induces Senescence in Tumor Cells and Elicits Prophylactic and Therapeutic Immune Responses against Breast Cancer Growth Mediated by NK Cells and CD4+ T Cells

(2012) M. Tkach et al.   JOURNAL OF IMMUNOLOGY

Tumor-Recruited Neutrophils and Neutrophil TIMP-Free MMP-9 Regulate Coordinately the Levels of Tumor Angiogenesis and Efficiency of Malignant Cell Intravasation

(2011) Erin M. Bekes et al.   AMERICAN JOURNAL OF PATHOLOGY

Signal transducer and activator of transcription 3 upregulates interleukin-8 expression at the level of transcription in human melanoma cells

(2009) Masahiro Oka et al.   EXPERIMENTAL DERMATOLOGY

A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass

(2008) Richard G. Moore et al.   GYNECOLOGIC ONCOLOGY

Signal Transducer and Activator of Transcription 3 Is Required for Hypoxia-Inducible Factor-1  RNA Expression in Both Tumor Cells and Tumor-Associated Myeloid Cells

(2008) G. Niu et al.   MOLECULAR CANCER RESEARCH