An Obligate Peptidyl Brominase Underlies the Discovery of Highly Distributed Biosynthetic Gene Clusters in Marine Sponge Microbiomes

Mechanisms of Action of Ribosomally Synthesized and Posttranslationally Modified Peptides (RiPPs)

(2021) Li Cao et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Presence of Bromotyrosine Alkaloids in Marine Sponges Is Independent of Metabolomic and Microbiome Architectures

(2021) Ipsita Mohanty et al.   mSystems

Characterization of a sponge microbiome using an integrative genome-centric approach

(2020) J. Pamela Engelberts et al.   ISME Journal

Landornamides: Antiviral Ornithine‐Containing Ribosomal Peptides Discovered through Genome Mining

(2020) Nina M. Bösch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli

(2020) Michael Rust et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmentally regulated volatiles geosmin and 2-methylisoborneol attract a soil arthropod to Streptomyces bacteria promoting spore dispersal

(2020) Paul G. Becher et al.   Nature Microbiology

A genomic view of trophic and metabolic diversity in clade-specific Lamellodysidea sponge microbiomes

(2020) Sheila Podell et al.   Microbiome

RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery

(2020) Alexander M. Kloosterman et al.   mSystems

Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

(2019) Silvia C Bobeica et al.   eLife

Chemical Ecology of Marine Sponges: New Opportunities through “-Omics”

(2019) Valerie J Paul et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Mass Spectrometry-Based Integration and Expansion of the Chemical Diversity Harbored Within a Marine Sponge

(2019) Thomas P. Cantrell et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

(2019) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

The Microbial Toxin Microcin B17: Prospects for the Development of New Antibacterial Agents

(2019) Frederic Collin et al.   JOURNAL OF MOLECULAR BIOLOGY

Use of a scaffold peptide in the biosynthesis of amino acid–derived natural products

(2019) Chi P. Ting et al.   SCIENCE

Genome mining- and synthetic biology-enabled production of hypermodified peptides

(2019) Agneya Bhushan et al.   Nature Chemistry

A computational framework to explore large-scale biosynthetic diversity

(2019) Jorge C. Navarro-Muñoz et al.   Nature Chemical Biology

Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition

(2019) Dmitrii Y. Travin et al.   Nature Communications

Marine natural product peptides with therapeutic potential: Chemistry, biosynthesis, and pharmacology

(2018) Vedanjali Gogineni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mechanistic Studies on Tryptophan Lyase (NosL): Identification of Cyanide as a Reaction Product

(2018) Dhananjay M. Bhandari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Parallel lives of symbionts and hosts: chemical mutualism in marine animals

(2018) Maho Morita et al.   NATURAL PRODUCT REPORTS

The sponge holobiont in a changing ocean: from microbes to ecosystems

(2018) L. Pita et al.   Microbiome

Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues

(2017) David K. Romney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges

(2017) Vinayak Agarwal et al.   Nature Chemical Biology

Evolutionary radiation of lanthipeptides in marine cyanobacteria

(2017) Andres Cubillos-Ruiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo

(2017) Sunil V. Sharma et al.   Nature Communications

In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products

(2016) Caitlin D. Deane et al.   ACS Chemical Biology

A Lanthipeptide-like N-Terminal Leader Region Guides Peptide Epimerization by Radical SAM Epimerases: Implications for RiPP Evolution

(2016) Sebastian W. Fuchs et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diversity, structure and convergent evolution of the global sponge microbiome

(2016) Torsten Thomas et al.   Nature Communications

Brominated Variant of the Lantibiotic NAI-107 with Enhanced Antibacterial Potency

(2015) João C. S. Cruz et al.   JOURNAL OF NATURAL PRODUCTS

Structural analysis of leader peptide binding enables leader-free cyanobactin processing

(2015) Jesko Koehnke et al.   Nature Chemical Biology

A prevalent peptide-binding domain guides ribosomal natural product biosynthesis

(2015) Brandon J Burkhart et al.   Nature Chemical Biology

Marine chemical ecology in benthic environments

(2014) Melany P. Puglisi et al.   NATURAL PRODUCT REPORTS

An environmental bacterial taxon with a large and distinct metabolic repertoire

(2014) Micheal C. Wilson et al.   NATURE

Chemical defenses and resource trade-offs structure sponge communities on Caribbean coral reefs

(2014) T.-L. Loh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition Sequences and Substrate Evolution in Cyanobactin Biosynthesis

(2014) Debosmita Sardar et al.   ACS Synthetic Biology

Meroterpenes from Marine Invertebrates: Structures, Occurrence, and Ecological Implications

(2013) Marialuisa Menna et al.   Marine Drugs

Diversification of Monoterpene Indole Alkaloid Analogs through Cross-Coupling

(2013) Weerawat Runguphan et al.   ORGANIC LETTERS

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

(2012) M. F. Freeman et al.   SCIENCE

The Chemical Ecology of Sponges on Caribbean Reefs: Natural Products Shape Natural Systems

(2011) Joseph R. Pawlik   BIOSCIENCE

Bacterial symbionts and natural products

(2011) Jason M. Crawford et al.   CHEMICAL COMMUNICATIONS

Plantazolicin A and B: Structure Elucidation of Ribosomally Synthesized Thiazole/Oxazole Peptides fromBacillus amyloliquefaciensFZB42

(2011) Bahar Kalyon et al.   ORGANIC LETTERS

Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family

(2010) Daniel H Haft et al.   BMC BIOLOGY

Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes

(2010) L. C. Foulston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Perspective on Enzymatic Halogenation

(2008) Leah C. Blasiak et al.   ACCOUNTS OF CHEMICAL RESEARCH

Maturation of anEscherichiacoliRibosomal Peptide Antibiotic by ATP-Consuming N−P Bond Formation in Microcin C7

(2008) Rebecca F. Roush et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A global assembly line for cyanobactins

(2008) Mohamed S Donia et al.   Nature Chemical Biology