Emodin-induced autophagic cell death hinders epithelial–mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis

Salvianolic acid B attenuates epithelial-mesenchymal transition in renal fibrosis rats through activating Sirt1-mediated autophagy

(2020) Yu He et al.   BIOMEDICINE & PHARMACOTHERAPY

Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway

(2020) Fan Yang et al.   Drug Design Development and Therapy

Activation of the angiotensin II receptor promotes autophagy in renal proximal tubular cells and affords protection from ischemia/reperfusion injury

(2020) Hirohito Sugawara et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7

(2019) Meng Wang et al.   EBioMedicine

Rapamycin activates mammalian microautophagy

(2019) Masahiro Sato et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes

(2019) Xiao-yuan Zheng et al.   Drug Design Development and Therapy

PD-L1 Expression Is Regulated By NF-κB During EMT Signaling In Gastric Carcinoma

(2019) Dan Xu et al.   OncoTargets and Therapy

Ablation of C/EBP homologous protein attenuates renal fibrosis after ureteral obstruction by reducing autophagy and microtubule disruption

(2018) Mi Ra Noh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Novel inhibitors of the cellular renin-angiotensin system components, poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis

(2018) Ming Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Up-regulation of microRNA-93 inhibits TGF-β1-induced EMT and renal fibrogenesis by down-regulation of Orai1

(2018) Jifang Ma et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Sphingolipid signaling in renal fibrosis

(2018) Andrea Huwiler et al.   MATRIX BIOLOGY

Effects of increased accumulation of doxorubicin due to emodin on efflux transporter and LRP1 expression in lung adenocarcinoma and colorectal carcinoma cells

(2018) Vidhya V. Iyer et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Formin-dependent TGF-β signaling for epithelial to mesenchymal transition

(2018) Manish K. Rana et al.   MOLECULAR BIOLOGY OF THE CELL

Canonical BMP signaling in tubular cells mediates recovery after acute kidney injury

(2018) Emilia Vigolo et al.   KIDNEY INTERNATIONAL

Sinomenine Hydrochloride Attenuates Renal Fibrosis by Inhibiting Excessive Autophagy Induced by Adriamycin: An Experimental Study

(2017) Ming-ming Zhao et al.   Evidence-based Complementary and Alternative Medicine

Sphingosine kinase 1 protects renal tubular epithelial cells from renal fibrosis via induction of autophagy

(2017) Chunyang Du et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2

(2017) Libin Ma et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

MiR-145-5p inhibits proliferation and inflammatory responses of RMC through regulating AKT/GSK pathway by targeting CXCL16

(2017) Junbiao Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Class I PI3K inhibitor S14161 induces autophagy in malignant blood cells by modulating the Beclin 1/Vps34 complex

(2017) Siyu Wang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

BMP-7 suppresses excessive scar formation by activating the BMP-7/Smad1/5/8 signaling pathway

(2017) Jingdong Guo et al.   Molecular Medicine Reports

Resveratrol inactivates PI3K/Akt signaling through upregulating BMP7 in human colon cancer cells

(2017) Yu-Hua Zeng et al.   ONCOLOGY REPORTS

Poricoic acid ZA, a novel RAS inhibitor, attenuates tubulo-interstitial fibrosis and podocyte injury by inhibiting TGF-β/Smad signaling pathway

(2017) Ming Wang et al.   PHYTOMEDICINE

Emodin reverses leukemia multidrug resistance by competitive inhibition and downregulation of P-glycoprotein

(2017) Hongping Min et al.   PLoS One

Emodin suppresses TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells through Notch signaling pathway

(2017) Rundi Gao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Emodin, a natural inhibitor of protein kinase CK2, suppresses growth, hyphal development, and biofilm formation of Candida albicans

(2017) Monika Janeczko et al.   YEAST

Emodin Enhances the Chemosensitivity of Endometrial Cancer by Inhibiting ROS-Mediated Cisplatin-resistance

(2017) Ning Ding et al.   Anti-Cancer Agents in Medicinal Chemistry

Emodin ameliorates cisplatin-induced apoptosis of rat renal tubular cells in vitro by activating autophagy

(2016) Hong Liu et al.   ACTA PHARMACOLOGICA SINICA

Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction

(2016) Man J. Livingston et al.   Autophagy

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

BMP-7 attenuated silica-induced pulmonary fibrosis through modulation of the balance between TGF-β/Smad and BMP-7/Smad signaling pathway

(2016) Di Liang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation

(2016) Ruijuan Guan et al.   Scientific Reports

Pathway reporter genes define molecular phenotypes of human cells

(2015) Jitao David Zhang et al.   BMC GENOMICS

Emodin Ameliorates High Glucose Induced-Podocyte Epithelial-Mesenchymal Transition In-Vitro and In-Vivo

(2015) Tingfang Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Autophagy in renal diseases

(2015) Stéphanie De Rechter et al.   PEDIATRIC NEPHROLOGY

Rapamycin protects against gentamicin-induced acute kidney injury via autophagy in mini-pig models

(2015) Jing Cui et al.   Scientific Reports

Role of bone morphogenetic protein-7 in renal fibrosis

(2015) Rui Xi Li et al.   Frontiers in Physiology

Metabolomics analysis reveals the association between lipid abnormalities and oxidative stress, inflammation, fibrosis and Nrf2 dysfunction in aristolochic acid-induced nephropathy

(2015) Ying-Yong Zhao et al.   Scientific Reports

Autophagy activation reduces renal tubular injury induced by urinary proteins

(2014) Wei Jing Liu et al.   Autophagy

Dahuang Fuzi Decoction ameliorates tubular epithelial apoptosis and renal damage via inhibiting TGF-β1-JNK signaling pathway activation in vivo

(2014) Yue Tu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Autophagy Regulates TGF-  Expression and Suppresses Kidney Fibrosis Induced by Unilateral Ureteral Obstruction

(2014) Y. Ding et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms and biological functions of autophagy in diseased and ageing kidneys

(2014) Sophie Fougeray et al.   Nature Reviews Nephrology

Diuretics associated acute kidney injury: clinical and pathological analysis

(2014) Xiaojing Wu et al.   RENAL FAILURE

Emodin represses TWIST1-induced epithelial–mesenchymal transitions in head and neck squamous cell carcinoma cells by inhibiting the β-catenin and Akt pathways

(2013) Tzong-Der Way et al.   EUROPEAN JOURNAL OF CANCER

Resveratrol as a therapeutic agent for renal fibrosis induced by unilateral ureteral obstruction

(2013) Jin Liang et al.   RENAL FAILURE

Role of the TGF-β/BMP-7/Smad pathways in renal diseases

(2012) Xiao-Ming Meng et al.   CLINICAL SCIENCE

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Progesterone decreases bone morphogenetic protein (BMP) 7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells

(2010) A. Kodama et al.   HUMAN REPRODUCTION

In vitro anti-fibrotic activities of herbal compounds and herbs

(2009) Qin Hu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Emodin protects rat liver from CCl4-induced fibrogenesis via inhibition of hepatic stellate cells activation

(2009) Miao-Xian Dong et al.   WORLD JOURNAL OF GASTROENTEROLOGY