Emodin reverses leukemia multidrug resistance by competitive inhibition and downregulation of P-glycoprotein

Identification of galectin-1 as a novel mediator for chemoresistance in chronic myeloid leukemia cells

(2016) Wu Luo et al.   Oncotarget

Homology modelling of human P-glycoprotein

(2015) L. Domicevica et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Demethoxycurcumin Modulates Human P-Glycoprotein Function via Uncompetitive Inhibition of ATPase Hydrolysis Activity

(2015) Yu-Ning Teng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

An in silico protocol for identifying potential poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors from chemical databases

(2015) Miaomiao Niu et al.   NEW JOURNAL OF CHEMISTRY

The ability of molecular docking to unravel the controversy and challenges related to P-glycoprotein—a well-known, yet poorly understood drug transporter

(2014) Maen Zeino et al.   INVESTIGATIONAL NEW DRUGS

Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: Herb–drug interactions mediated via P-gp

(2014) Xue Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In Silico Study of Desmosdumotin as an Anticancer Agent: Homology Modeling, Docking and Molecular Dynamics Simulation Approach

(2013) Changdev Gadhe et al.   Anti-Cancer Agents in Medicinal Chemistry

Role of organic cation transporter OCT2 and multidrug and toxin extrusion proteins MATE1 and MATE2-K for transport and drug interactions of the antiviral lamivudine

(2013) Fabian Müller et al.   BIOCHEMICAL PHARMACOLOGY

HZ08 inhibits the multi-drug resistance on multiple sites as the substrate of p-glycoprotein

(2013) Yidong Feng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular Docking Characterizes Substrate-Binding Sites and Efflux Modulation Mechanisms within P-Glycoprotein.

(2013) Ricardo J. Ferreira et al.   Journal of Chemical Information and Modeling

AZT and emodin exhibit synergistic growth-inhibitory effects on K562/ADM cells by inducing S phase cell cycle arrest and suppressing MDR1 mRNA/p-gp protein expression

(2013) Peng Chen et al.   PHARMACEUTICAL BIOLOGY

Wnt/β-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia

(2012) Stephany Corrêa et al.   BMC CANCER

Anti-inflammatory properties of anthraquinones and their relationship with the regulation of P-glycoprotein function and expression

(2012) Ran Joo Choi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Can P-glycoprotein mediate resistance to nilotinib in human leukaemia cells?

(2012) Petr Kosztyu et al.   PHARMACOLOGICAL RESEARCH

Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro

(2011) DIAN-LEI LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Predicting Binding to P-Glycoprotein by Flexible Receptor Docking

(2011) Elena Dolghih et al.   PLoS Computational Biology

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE