Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain

Puerarin inhibits inflammation and oxidative stress in dextran sulfate sodium-induced colitis mice model

(2020) Yong-Deok Jeon et al.   BIOMEDICINE & PHARMACOTHERAPY

Nrf2 Ablation Promotes Alzheimer’s Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress

(2020) Peng Ren et al.   Oxidative Medicine and Cellular Longevity

Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications?

(2020) Carolina Pellegrini et al.   PROGRESS IN NEUROBIOLOGY

Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model

(2020) Ian F Harrison et al.   BRAIN

The NLRP3 inflammasome mediates DSS-induced intestinal inflammation in Nod2 knockout mice

(2019) Benjamin Umiker et al.   Innate Immunity

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes

(2019) Hemraj B. Dodiya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dietary Supplementation with Sea Bass (Lateolabrax maculatus) Ameliorates Ulcerative Colitis and Inflammation in Macrophages through Inhibiting Toll-Like Receptor 4-Linked Pathways

(2019) Jiali Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

(2019) Ji Hoon Ahn et al.   NATURE

The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review

(2019) Yoko M. Ambrosini et al.   Frontiers in Aging Neuroscience

Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2

(2019) Yuan Zhang et al.   Microbiome

Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner

(2018) Moumita Datta et al.   IMMUNITY

Influences and Impact of Anxiety and Depression in the Setting of Inflammatory Bowel Disease

(2018) Seyedehsan Navabi et al.   INFLAMMATORY BOWEL DISEASES

FasL incapacitation alleviates CD4 + T cells-induced brain injury through remodeling of microglia polarization in mouse ischemic stroke

(2018) Haoran Zhao et al.   JOURNAL OF NEUROIMMUNOLOGY

The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—a Critical Review

(2018) Marta Sochocka et al.   MOLECULAR NEUROBIOLOGY

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

(2018) Antoine Louveau et al.   NATURE NEUROSCIENCE

Comparative Epidemiological Investigation of Alzheimer’s Disease and Colorectal Cancer: The Possible Role of Gastrointestinal Conditions in the Pathogenesis of AD

(2018) Tianlang Zhang et al.   Frontiers in Aging Neuroscience

Social isolation, cognitive reserve, and cognition in older people with depression and anxiety

(2018) Isobel E. M. Evans et al.   AGING & MENTAL HEALTH

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

The Meningeal Lymphatic System: A New Player in Neurophysiology

(2018) Sandro Da Mesquita et al.   NEURON

Chronic colitis induces meninges traffic of gut-derived T cells, unbalances M1 and M2 microglia/macrophage and increases ischemic brain injury in mice

(2018) Yukun Feng et al.   BRAIN RESEARCH

Enhanced susceptibility of triple transgenic Alzheimer’s disease (3xTg-AD) mice to acute infection

(2017) Rebecca Montacute et al.   Journal of Neuroinflammation

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

(2017) Chia-Chen Liu et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis

(2017) Xiaomin Yao et al.   Nature Communications

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

(2017) Xiao-fei He et al.   Frontiers in Molecular Neuroscience

Deferoxamine inhibits microglial activation, attenuates blood-brain barrier disruption, rescues dendritic damage, and improves spatial memory in a mouse model of microhemorrhages

(2016) Xiao-fei He et al.   JOURNAL OF NEUROCHEMISTRY

Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke

(2016) V. Singh et al.   JOURNAL OF NEUROSCIENCE

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

(2016) Christian Schläger et al.   NATURE

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

(2015) Adam C. Kaufman et al.   ANNALS OF NEUROLOGY

The tantalizing links between gut microbes and the brain

(2015) Peter Andrey Smith   NATURE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice

(2015) Michael L. Seibenhener et al.   Jove-Journal of Visualized Experiments

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Inhibitory Effect of the Gallotannin Corilagin on Dextran Sulfate Sodium-Induced Murine Ulcerative Colitis

(2013) Hai-Tao Xiao et al.   JOURNAL OF NATURAL PRODUCTS

Evidence for impaired amyloid β clearance in Alzheimer's disease

(2013) Kristin R Wildsmith et al.   Alzheimers Research & Therapy

Late-Life Depression, Mild Cognitive Impairment, and Dementia

(2013) Edo Richard et al.   JAMA Neurology

Brain-Gut Interactions in Inflammatory Bowel Disease

(2012) Bruno L. Bonaz et al.   GASTROENTEROLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Inhibition of Ulcerative Colitis in Mice after Oral Administration of a Polyphenol-Enriched Cocoa Extract Is Mediated by the Inhibition of STAT1 and STAT3 Phosphorylation in Colon Cells

(2011) Isabel Andújar et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY