Soluble epoxide hydrolase inhibition Promotes White Matter Integrity and Long-Term Functional Recovery after chronic hypoperfusion in mice

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(2016) Nusrat Matin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Brain-peripheral cell crosstalk in white matter damage and repair

(2016) Kazuhide Hayakawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury

(2016) Alok Kumar et al.   JOURNAL OF NEUROTRAUMA

Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress

(2016) Qian Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

White matter injury in ischemic stroke

(2016) Yuan Wang et al.   PROGRESS IN NEUROBIOLOGY

Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy

(2015) Yu-Wen Hung et al.   BRAIN BEHAVIOR AND IMMUNITY

Selective modulation of microglia polarization to M2 phenotype for stroke treatment

(2015) Cong-Yuan Xia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Epoxyeicosanoid Signaling Provides Multi-target Protective Effects on Neurovascular Unit in Rats After Focal Ischemia

(2015) Yang Liu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury

(2015) Xiaojing Chen et al.   MOLECULAR NEUROBIOLOGY

Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU): Resulting drug levels and modulation of oxylipin pattern

(2015) Annika I. Ostermann et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Oligodendrocyte Pathophysiology and Treatment Strategies in Cerebral Ischemia

(2014) Gabriella Mifsud et al.   CNS Neuroscience & Therapeutics

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(2014) Steven A Goldman et al.   NATURE NEUROSCIENCE

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models

(2013) Jun-Yan Liu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Oxidative Stress Interferes With White Matter Renewal After Prolonged Cerebral Hypoperfusion in Mice

(2013) Nobukazu Miyamoto et al.   STROKE

Oligodendrogenesis after cerebral ischemia

(2013) Ruilan Zhang et al.   Frontiers in Cellular Neuroscience

Fibroblast Growth Factor Receptor Signaling in Oligodendrocytes Regulates Myelin Sheath Thickness

(2012) M. Furusho et al.   JOURNAL OF NEUROSCIENCE

Myelin Loss Associated With Neuroinflammation in Hypertensive Rats

(2012) Fakhreya Y. Jalal et al.   STROKE

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(2012) Carlos Matute et al.   STROKE

The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases

(2011) Xizhen Xu et al.   ADVANCED DRUG DELIVERY REVIEWS

The anti-inflammatory effects of soluble epoxide hydrolase inhibitors are independent of leukocyte recruitment

(2011) Benjamin B. Davis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The hippocampal fimbria of cuprizone-treated animals as a structure for studying neuroprotection in multiple sclerosis

(2011) M. Kipp et al.   INFLAMMATION RESEARCH

Epoxyeicosatrienoic Acid Analogs and Vascular Function

(2010) V. Sudhahar et al.   CURRENT MEDICINAL CHEMISTRY

Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus

(2010) Sung-Eun Kim et al.   EXPERIMENTAL GERONTOLOGY

1-Aryl-3-(1-acylpiperidin-4-yl)urea Inhibitors of Human and Murine Soluble Epoxide Hydrolase: Structure−Activity Relationships, Pharmacokinetics, and Reduction of Inflammatory Pain

(2010) Tristan E. Rose et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

(2010) Leonardo Pantoni   LANCET NEUROLOGY

Oligodendrocyte degeneration and recovery after focal cerebral ischemia

(2010) S.R. McIver et al.   NEUROSCIENCE

Soluble Epoxide Inhibition Is Protective Against Cerebral Ischemia via Vascular and Neural Protection

(2009) Alexis N. Simpkins et al.   AMERICAN JOURNAL OF PATHOLOGY

Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels

(2009) Jeffrey J. Iliff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Oligovascular Signaling in White Matter Stroke

(2009) Ken Arai et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

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(2009) Ken Arai et al.   FEBS Journal

Evolution of Inflammation and White Matter Injury in a Model of Transient Focal Ischemia

(2009) Iska Moxon-Emre et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Epoxyeicosanoid signaling in CNS function and disease

(2009) Jeffrey J. Iliff et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Soluble Epoxide Hydrolase Gene Deletion Is Protective Against Experimental Cerebral Ischemia

(2008) Wenri Zhang et al.   STROKE

Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia

(2007) Ines et al.   Frontiers in Bioscience-Landmark